KR860001869B1 - 이미다졸리딘디온 유도체의 제조방법 - Google Patents

이미다졸리딘디온 유도체의 제조방법 Download PDF

Info

Publication number
KR860001869B1
KR860001869B1 KR1019840002843A KR840002843A KR860001869B1 KR 860001869 B1 KR860001869 B1 KR 860001869B1 KR 1019840002843 A KR1019840002843 A KR 1019840002843A KR 840002843 A KR840002843 A KR 840002843A KR 860001869 B1 KR860001869 B1 KR 860001869B1
Authority
KR
South Korea
Prior art keywords
spiro
hydrogen
amino
formula
trione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840002843A
Other languages
English (en)
Korean (ko)
Other versions
KR840009101A (ko
Inventor
제프레이 후치슨 알랜
Original Assignee
화이자 인포퍼레이티드
테렌스 제이. 갈라거
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 인포퍼레이티드, 테렌스 제이. 갈라거 filed Critical 화이자 인포퍼레이티드
Publication of KR840009101A publication Critical patent/KR840009101A/ko
Priority to KR1019860007876A priority Critical patent/KR860001870B1/ko
Application granted granted Critical
Publication of KR860001869B1 publication Critical patent/KR860001869B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
KR1019840002843A 1983-05-25 1984-05-24 이미다졸리딘디온 유도체의 제조방법 Expired KR860001869B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860007876A KR860001870B1 (ko) 1983-05-25 1986-09-20 이미다졸리딘디온 유도체의 제조방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US497962 1983-05-25
US06/497,962 US4464380A (en) 1983-05-25 1983-05-25 Imidazolidinedione derivatives
US497,962 1983-05-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019860007876A Division KR860001870B1 (ko) 1983-05-25 1986-09-20 이미다졸리딘디온 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR840009101A KR840009101A (ko) 1984-12-24
KR860001869B1 true KR860001869B1 (ko) 1986-10-24

Family

ID=23979057

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002843A Expired KR860001869B1 (ko) 1983-05-25 1984-05-24 이미다졸리딘디온 유도체의 제조방법

Country Status (19)

Country Link
US (1) US4464380A (OSRAM)
EP (1) EP0127412B1 (OSRAM)
JP (1) JPS604183A (OSRAM)
KR (1) KR860001869B1 (OSRAM)
AT (1) ATE57531T1 (OSRAM)
AU (1) AU543916B2 (OSRAM)
CA (1) CA1266270A (OSRAM)
DE (1) DE3483402D1 (OSRAM)
DK (1) DK163924C (OSRAM)
ES (2) ES532736A0 (OSRAM)
FI (1) FI78699C (OSRAM)
GR (1) GR82020B (OSRAM)
HU (1) HU190548B (OSRAM)
IE (1) IE57520B1 (OSRAM)
IL (1) IL71904A (OSRAM)
PH (1) PH21151A (OSRAM)
PL (3) PL143070B1 (OSRAM)
PT (1) PT78625A (OSRAM)
YU (2) YU43931B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3565105D1 (en) * 1984-08-20 1988-10-27 Pfizer Process for the production as asymmetric hydantoins
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
ES2187603T3 (es) * 1995-10-18 2003-06-16 Hoffmann La Roche Hidroximetilacion de tocoferoles.
US7148214B1 (en) 1998-12-19 2006-12-12 Janssen Pharmaceutica, N.V. Antihistaminic spiro compounds
JP2009526044A (ja) * 2006-02-07 2009-07-16 アストラゼネカ・アクチエボラーグ 新規な化合物ｉ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
ZA806623B (en) * 1979-11-13 1981-12-30 Ici Ltd Substituted indoline-2-one derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives

Also Published As

Publication number Publication date
YU89784A (en) 1987-04-30
IL71904A0 (en) 1984-09-30
FI842079A0 (fi) 1984-05-24
EP0127412B1 (en) 1990-10-17
DK250084A (da) 1984-11-26
EP0127412A2 (en) 1984-12-05
PH21151A (en) 1987-07-30
IE841294L (en) 1984-11-25
FI78699C (fi) 1989-09-11
KR840009101A (ko) 1984-12-24
PL143070B1 (en) 1988-01-30
ES8600764A1 (es) 1985-10-16
ES532736A0 (es) 1985-10-16
ES8607304A1 (es) 1986-06-01
EP0127412A3 (en) 1987-09-02
YU43931B (en) 1989-12-31
DK163924C (da) 1992-09-14
CA1266270A (en) 1990-02-27
PL143290B1 (en) 1988-02-29
IE57520B1 (en) 1993-05-19
AU2856384A (en) 1984-11-29
ES540858A0 (es) 1986-06-01
PL252850A1 (en) 1985-11-19
PT78625A (en) 1984-06-01
HU190548B (en) 1986-09-29
YU43958B (en) 1989-12-31
PL247804A1 (en) 1985-08-13
FI842079A7 (fi) 1984-11-26
ATE57531T1 (de) 1990-11-15
IL71904A (en) 1988-01-31
DE3483402D1 (de) 1990-11-22
HUT34194A (en) 1985-02-28
AU543916B2 (en) 1985-05-09
US4464380A (en) 1984-08-07
DK250084D0 (da) 1984-05-22
JPH0573754B2 (OSRAM) 1993-10-15
DK163924B (da) 1992-04-21
FI78699B (fi) 1989-05-31
JPS604183A (ja) 1985-01-10
YU212286A (en) 1987-10-31
GR82020B (OSRAM) 1984-12-12

Similar Documents

Publication Publication Date Title
US4855298A (en) 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2'5'-triones useful for the treatment and prophylaxis of diabetic complications
JPH07149723A (ja) １−アミノエチルインドール誘導体
EP0034063B1 (en) Hydantoin amines and pharmaceutical compositions thereof
WO1993012786A1 (en) Indolinone derivatives
US4333934A (en) Imidazoquinoxalines and pyrroloquinoxalines
KR860001869B1 (ko) 이미다졸리딘디온 유도체의 제조방법
US4235911A (en) Hydantoin derivatives
EP0266102B1 (en) Quinoxalinone derivatives
US4734501A (en) N-alkylation of dihydrolysergic acid
EP0269355B1 (en) Imidazolidinedione derivatives
WO2001044228A2 (fr) Derives de quinazolinedione et phtalimide, leurs preparations et leurs applications en therapeutique
JPH0643421B2 (ja) ピリミジン誘導体
KR860001870B1 (ko) 이미다졸리딘디온 유도체의 제조방법
US4533667A (en) Imidazolidinedione derivatives
KR860001583B1 (ko) 6-아닐리노-5,8-퀴녹살린 디온의 제조방법
EP0127143B1 (en) Novel aryloxycycloalkanolaminoalkylene aryl ketones
EP0028485A1 (en) Spiro-imidazolones for alleviating diabetes-associated conditions, processes for preparing them, and pharmaceutical compositions containing them
FR2531709A1 (fr) Diazabicyclooctanes, procede pour leur preparation et compositions pharmaceutiques les renfermant
US4644002A (en) Imidazo[2,1-C]quinolines, useful as antiallergic agents
FR2792635A1 (fr) Derives de cyclobutene-3,4-dione leur preparation et leur application en therapeutique
IE49659B1 (en) Spiro-quinolone hydantoins,pharmaceutical compositions containing them,and processes for their preparation
JPH0745498B2 (ja) ｔ−ブチルエルゴリン誘導体
IE920120A1 (en) 2,4-DIOXO-PYRIDO[2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS¹AND SALTS THEREOF
KR100427127B1 (ko) 벤조[3,4]사이클로부타[1,2-c]피롤 화합물, 이것의 제조 방법 및 이것을 함유하는 약제 조성물
WO2000020412A1 (fr) Derives de quinazolinedione, leurs preparations et leurs applications en therapeutique

Legal Events

Date Code Title Description
A201 Request for examination
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 19920805

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19931025

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19931025

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000