DK163924C - Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer - Google Patents

Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer

Info

Publication number
DK163924C
DK163924C DK250084A DK250084A DK163924C DK 163924 C DK163924 C DK 163924C DK 250084 A DK250084 A DK 250084A DK 250084 A DK250084 A DK 250084A DK 163924 C DK163924 C DK 163924C
Authority
DK
Denmark
Prior art keywords
spiro
compounds
trione
imidazolidine
oeimidazolidin
Prior art date
Application number
DK250084A
Other languages
English (en)
Other versions
DK250084D0 (da
DK163924B (da
DK250084A (da
Inventor
Alan Jeffrey Hutchison
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK250084D0 publication Critical patent/DK250084D0/da
Publication of DK250084A publication Critical patent/DK250084A/da
Publication of DK163924B publication Critical patent/DK163924B/da
Application granted granted Critical
Publication of DK163924C publication Critical patent/DK163924C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • External Artificial Organs (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK250084A 1983-05-25 1984-05-22 Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer DK163924C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49796283 1983-05-25
US06/497,962 US4464380A (en) 1983-05-25 1983-05-25 Imidazolidinedione derivatives

Publications (4)

Publication Number Publication Date
DK250084D0 DK250084D0 (da) 1984-05-22
DK250084A DK250084A (da) 1984-11-26
DK163924B DK163924B (da) 1992-04-21
DK163924C true DK163924C (da) 1992-09-14

Family

ID=23979057

Family Applications (1)

Application Number Title Priority Date Filing Date
DK250084A DK163924C (da) 1983-05-25 1984-05-22 Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer

Country Status (19)

Country Link
US (1) US4464380A (da)
EP (1) EP0127412B1 (da)
JP (1) JPS604183A (da)
KR (1) KR860001869B1 (da)
AT (1) ATE57531T1 (da)
AU (1) AU543916B2 (da)
CA (1) CA1266270A (da)
DE (1) DE3483402D1 (da)
DK (1) DK163924C (da)
ES (2) ES532736A0 (da)
FI (1) FI78699C (da)
GR (1) GR82020B (da)
HU (1) HU190548B (da)
IE (1) IE57520B1 (da)
IL (1) IL71904A (da)
PH (1) PH21151A (da)
PL (3) PL252850A1 (da)
PT (1) PT78625A (da)
YU (2) YU43931B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE37371T1 (de) * 1984-08-20 1988-10-15 Pfizer Verfahren zur herstellung asymmetrischer hydantoine.
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
EP0769497B1 (de) * 1995-10-18 2002-12-18 F. Hoffmann-La Roche Ag Hydroxymethylierung von Tocopherolen
HU229406B1 (en) 1998-12-19 2013-12-30 Janssen Pharmaceutica Nv Antihistaminic spiro compounds
CN101415713A (zh) * 2006-02-07 2009-04-22 阿斯利康(瑞典)有限公司 用于治疗香草素受体1相关病症的新螺[咪唑烷-4,3’-吲哚]-2,2’,5(1’h)-三酮

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
ZA806623B (en) * 1979-11-13 1981-12-30 Ici Ltd Substituted indoline-2-one derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives

Also Published As

Publication number Publication date
FI78699C (fi) 1989-09-11
PT78625A (en) 1984-06-01
YU212286A (en) 1987-10-31
EP0127412B1 (en) 1990-10-17
YU43958B (en) 1989-12-31
DE3483402D1 (de) 1990-11-22
AU543916B2 (en) 1985-05-09
HU190548B (en) 1986-09-29
EP0127412A2 (en) 1984-12-05
KR840009101A (ko) 1984-12-24
IL71904A0 (en) 1984-09-30
IL71904A (en) 1988-01-31
ES540858A0 (es) 1986-06-01
JPS604183A (ja) 1985-01-10
IE57520B1 (en) 1993-05-19
KR860001869B1 (ko) 1986-10-24
US4464380A (en) 1984-08-07
DK250084D0 (da) 1984-05-22
IE841294L (en) 1984-11-25
PL247804A1 (en) 1985-08-13
HUT34194A (en) 1985-02-28
EP0127412A3 (en) 1987-09-02
ATE57531T1 (de) 1990-11-15
PL252850A1 (en) 1985-11-19
PL143290B1 (en) 1988-02-29
ES8607304A1 (es) 1986-06-01
FI78699B (fi) 1989-05-31
CA1266270A (en) 1990-02-27
PL143070B1 (en) 1988-01-30
ES8600764A1 (es) 1985-10-16
GR82020B (da) 1984-12-12
ES532736A0 (es) 1985-10-16
YU89784A (en) 1987-04-30
FI842079A (fi) 1984-11-26
AU2856384A (en) 1984-11-29
DK163924B (da) 1992-04-21
FI842079A0 (fi) 1984-05-24
PH21151A (en) 1987-07-30
JPH0573754B2 (da) 1993-10-15
YU43931B (en) 1989-12-31
DK250084A (da) 1984-11-26

Similar Documents

Publication Publication Date Title
DK160460C (da) Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet
AU3799789A (en) Novel benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
ATE110071T1 (de) Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DK56581A (da) Fremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf
DK163924C (da) Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer
AU7767287A (en) New imidazolylguanidine derivatives, processes for their preparation and medicaments containing these compounds
IE851155L (en) Benzo-(pyrano and thiopyrano)-pyridines
ATE80616T1 (de) Prostaglandin e1-derivate und ihre therapeutische anwendung.
ES8400116A1 (es) "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".
IE800109L (en) Spiro-quinolylhydantoins
ES8607312A1 (es) Un procedimiento para la preparacion de un compuesto seleccionado entre el grupo formado por los isomeros dextrogiros de espiro-hidantoinas asimetricas
IE800672L (en) Spiro-quinolone hydantoins
MY103765A (en) Azolidinedione derivatives
DK451184A (da) 3-alkyl-7-halogen-2,3-dihydro-spiro(naphthalen-1(4h), 3'-pyrrolidin)-2',4,5'-trioner og farmaceutiske praeparater indeholdende disse
HUT44769A (en) Process for producing spiro/benzofuran-2(3h),1'-cycloheptane/ derivatives and pharmaceutical preparations comprising these compounds
EP0270292A3 (en) Radiation sensitizers
UA7042A1 (uk) Спосіб одержання похідних імідазола або їх фізіологічно прийнятих солей
NO882279D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive endo-bicyklo (2,2,1) heptyl-adenosin-derivater.

Legal Events

Date Code Title Description
PBP Patent lapsed