ES8400116A1 - "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona". - Google Patents

"un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".

Info

Publication number
ES8400116A1
ES8400116A1 ES515751A ES515751A ES8400116A1 ES 8400116 A1 ES8400116 A1 ES 8400116A1 ES 515751 A ES515751 A ES 515751A ES 515751 A ES515751 A ES 515751A ES 8400116 A1 ES8400116 A1 ES 8400116A1
Authority
ES
Spain
Prior art keywords
spiro
trione
oxazolidine
indoline
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515751A
Other languages
English (en)
Other versions
ES515751A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8400116A1 publication Critical patent/ES8400116A1/es
Publication of ES515751A0 publication Critical patent/ES515751A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ESPIRO-OXINDOL-OXAZOLIDINDIONA Y DE SUS SALES BASICAS CON CATIONES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X, Y, Z Y R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE UNA ISATINA DE FORMULA (II), EN LA QUE X, Y, Z Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN CIANURO DE TRIALQUILSILILO INFERIOR; SEGUIDA DEL TRATAMIENTO DEL PRODUCTO OBTENIDO CON CLORURO DE HIDROGENO ALCOHOLICO; REACCION CON ISOCIANATO DE CLOROSULFONILO EN TETRAHIDROFURANO E HIDROLISIS REDUCTIVAPARA FORMAR EL CORRESPONDIENTE ESTER DE URETANO; Y, FINALMENTE CICLIZACION DE ESTE ESTER EN UN DISOLVENTE INERTE, EN CONDICIONES ACIDAS.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE CATARATAS DIABETICAS, RETINOPATIAS Y NEUROPATIAS.
ES515751A 1981-10-13 1982-09-16 "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona". Granted ES515751A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31068281A 1981-10-13 1981-10-13

Publications (2)

Publication Number Publication Date
ES8400116A1 true ES8400116A1 (es) 1983-10-16
ES515751A0 ES515751A0 (es) 1983-10-16

Family

ID=23203647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515751A Granted ES515751A0 (es) 1981-10-13 1982-09-16 "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".

Country Status (16)

Country Link
EP (1) EP0079675A1 (es)
JP (1) JPS5877883A (es)
KR (1) KR860000486B1 (es)
AR (1) AR231839A1 (es)
AU (1) AU531161B2 (es)
CA (1) CA1171860A (es)
DK (1) DK449882A (es)
ES (1) ES515751A0 (es)
FI (1) FI823480L (es)
GR (1) GR77019B (es)
HU (1) HU185113B (es)
IL (1) IL66954A (es)
PH (1) PH18038A (es)
PL (1) PL238595A1 (es)
PT (1) PT75673B (es)
YU (1) YU229382A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA832679B (en) * 1982-05-07 1983-12-28 Ici Plc Indoline derivatives
EP0159143B1 (en) * 1984-03-23 1987-12-16 Pfizer Inc. Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
HU203330B (en) * 1987-06-10 1991-07-29 Pfizer Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them
AU617541B2 (en) * 1988-10-20 1991-11-28 Wyeth Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
US5221686A (en) * 1992-08-04 1993-06-22 American Home Products Corporation Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
CN102336769A (zh) * 2011-07-06 2012-02-01 华东理工大学 一种简便的合成螺[氧化吲哚-3,5＇-噁唑啉]杂环化合物的新方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones

Also Published As

Publication number Publication date
PT75673B (en) 1985-12-09
DK449882A (da) 1983-04-14
ES515751A0 (es) 1983-10-16
HU185113B (en) 1984-12-28
CA1171860A (en) 1984-07-31
PT75673A (en) 1982-11-01
KR840002002A (ko) 1984-06-11
YU229382A (en) 1984-12-31
AU8928882A (en) 1983-04-21
GR77019B (es) 1984-09-04
PL238595A1 (en) 1983-09-12
JPS5877883A (ja) 1983-05-11
AR231839A1 (es) 1985-03-29
PH18038A (en) 1985-03-08
AU531161B2 (en) 1983-08-11
IL66954A0 (en) 1983-02-23
FI823480L (fi) 1983-04-14
IL66954A (en) 1985-02-28
EP0079675A1 (en) 1983-05-25
JPS611073B2 (es) 1986-01-13
FI823480A0 (fi) 1982-10-12
KR860000486B1 (ko) 1986-04-30

Similar Documents

Publication Publication Date Title
YU69289A (en) Substituted flavonoidic compounds, their salts and process for producing thereof
AU3256789A (en) Topical preparation for treating otopathy
ES8400116A1 (es) "un procedimiento por analogia para la preparacion de derivados de espiro-oxindol-oxazolidindiona".
ES8607304A1 (es) Un procedimiento para la preparacion de derivados de espiro-hidantoina
DE3070735D1 (en) 4-aryloxy-3-phenylpiperidine derivatives, intermediates, a process for the preparation of such compounds and their use as medicaments
PL245745A1 (en) Process for preparing derivatives of arylthioazolidinodione
MY103765A (en) Azolidinedione derivatives
AU7719491A (en) Therapeutic compound