ES2187603T3 - Hidroximetilacion de tocoferoles. - Google Patents

Hidroximetilacion de tocoferoles.

Info

Publication number
ES2187603T3
ES2187603T3 ES96116152T ES96116152T ES2187603T3 ES 2187603 T3 ES2187603 T3 ES 2187603T3 ES 96116152 T ES96116152 T ES 96116152T ES 96116152 T ES96116152 T ES 96116152T ES 2187603 T3 ES2187603 T3 ES 2187603T3
Authority
ES
Spain
Prior art keywords
hydroximetilation
tocopheroles
tocopherols
alpha
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96116152T
Other languages
English (en)
Inventor
Konrad Bruggemann
Juan Ramon Herguijuela
Thomas Netscher
Johann Riegl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2187603T3 publication Critical patent/ES2187603T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EN UN PROCEDIMIENTO PARA LA TRANSFORMACION DE TOCOFEROLES QUE NO SEAN {AL} EN {AL}-TOCOFEROLES MEDIANTE LA REACCION DE AL MENOS UN TOCOFEROL NO {AL} CON FORMALDEHIDO O UN DERIVADO DE EL EN PRESENCIA DE ACIDO BORICO O DE UN DERIVADO BAJO CONDICIONES CATALITICAS REDUCTORAS, SE UTILIZAN COMO DISOLVENTES CON LA FUNCION ADICIONAL DE CATALIZADOR UNA MEZCLA AZEOTROPICA DE BORATO DE TRIMETILO Y METANOL Y COMO DISOLVENTE ADICIONAL UN DISOLVENTE ORGANICO APOLAR. LA REALIZACION DE ESTE PROCEDIMIENTO ES TAMBIEN OBJETO DE LA INVENCION, Y CONSISTE EN QUE, LA MEZCLA QUE QUEDA DESPUES DE LA REACCION SE TRATA CON METANOL, DISOLVIENDOSE EL ACIDO BORICO EN EL METANOL, LA SOLUCION OBTENIDA, QUE SI SE DESEA SE PUEDE LAVAR PARA RETIRAR EL DISOLVENTE ORGANICO APOLAR, SE FILTRA PARA SEPARAR EL CATALIZADOR SOLIDO, EL FILTRADO (TOTAL) SE TRATA CON AGUA, DESPUES DE LA SEPARACION DE FASES EL DISOLVENTE ORGANICO POLAR SE RETIRA DE LA FASE ORGANICA POR DESTILACION, PARA LIBERAR EL PRODUCTO QUE ES {AL}-TOCOFEROL, Y SE SOMETE LA FASE ACUOSA, QUE ESTA FORMADA PRINCIPALMENTE DE METANOL, AGUA Y ACIDO BORICO, A UNA DENOMINADA DESTILACION REACTIVA, PARA SEPARAR EL BORATO DE TRIMETILO OBTENIDO EN LA DESTILACION A CAUSA DE LA ESTERIFICACION DEL ACIDO BORICO CON METANOL, COMO MEZCLA "AZEOTROPICA" DEL BORATO DE TRIMETILO Y DEL METANOL. UTILIZANDO ESTE PROCEDIMIENTO SE PUEDE AISLAR EL PRODUCTO OBTENIDO DE LA REACCION QUE ES PRINCIPALMENTE {AL}TOCOFEROL, Y SE PUEDEN AISLAR EL METANOL, EL AGUA, EL DISOLVENTE ORGANICO APOLAR, EL CATALIZADOR DE HIDROGENACION ASI COMO EL ACIDO BORICO COMO MEZCLA "AZEOTROPICA" DEL BORATO DE TRIMETILO Y DEL METANOL, Y UTILIZARSE OTRA VEZ.
ES96116152T 1995-10-18 1996-10-09 Hidroximetilacion de tocoferoles. Expired - Lifetime ES2187603T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH295195 1995-10-18

Publications (1)

Publication Number Publication Date
ES2187603T3 true ES2187603T3 (es) 2003-06-16

Family

ID=4245319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96116152T Expired - Lifetime ES2187603T3 (es) 1995-10-18 1996-10-09 Hidroximetilacion de tocoferoles.

Country Status (8)

Country Link
US (1) US5892058A (es)
EP (1) EP0769497B1 (es)
JP (1) JPH09124635A (es)
CN (1) CN1090626C (es)
AT (1) ATE229948T1 (es)
DE (1) DE59609995D1 (es)
DK (1) DK0769497T3 (es)
ES (1) ES2187603T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932748A (en) * 1997-06-06 1999-08-03 Roche Vitamins Inc. Process for permethylating non-α-tocopherols to produce α-tocopherol
US6429320B1 (en) 2000-08-04 2002-08-06 Cognis Corporation Processes for the purification of tocopherol and/or sterol compounds and compositions containing orthoborate ester mixtures
DE10346037A1 (de) * 2003-10-02 2005-04-28 Basf Ag Herstellung von alpha-Tocopherol aus nicht alpha-Tocopherole enthaltendem Rohmaterial
EP3233776B1 (en) 2014-12-17 2019-10-23 DSM IP Assets B.V. Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of gold(i) complexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031495A (en) * 1964-01-24 1966-06-02 Eisai Co Ltd Process for producing ª‡-tocopherol having a high vitamin e activity
US3819657A (en) * 1972-10-20 1974-06-25 Gen Mills Chem Inc Methylation of tocopherols
JPS516761A (ja) * 1974-07-08 1976-01-20 Suwa Seikosha Kk Udedokei
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
EP0178400A1 (en) * 1984-09-25 1986-04-23 HENKEL CORPORATION (a Delaware corp.) Methylation of non-alpha-tocopherol compounds
US4617406A (en) * 1985-02-11 1986-10-14 Henkel Corporation Purification of tocopherols

Also Published As

Publication number Publication date
EP0769497B1 (de) 2002-12-18
JPH09124635A (ja) 1997-05-13
EP0769497A1 (de) 1997-04-23
DE59609995D1 (de) 2003-01-30
DK0769497T3 (da) 2003-04-07
ATE229948T1 (de) 2003-01-15
CN1090626C (zh) 2002-09-11
US5892058A (en) 1999-04-06
CN1151988A (zh) 1997-06-18

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