KR850001208A - 이미다졸 유도체의 제조방법 - Google Patents
이미다졸 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850001208A KR850001208A KR1019840003852A KR840003852A KR850001208A KR 850001208 A KR850001208 A KR 850001208A KR 1019840003852 A KR1019840003852 A KR 1019840003852A KR 840003852 A KR840003852 A KR 840003852A KR 850001208 A KR850001208 A KR 850001208A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- imidazo
- formula
- groups
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims 14
- 150000002460 imidazoles Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 claims 13
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 10
- 238000006243 chemical reaction Methods 0.000 claims 7
- -1 hydroxy, amino Chemical group 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 5
- UBOOKRVGOBKDMM-UHFFFAOYSA-N 3h-imidazo[4,5-c]pyridine Chemical compound C1=NC=C2NC=NC2=C1 UBOOKRVGOBKDMM-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005336 allyloxy group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000007062 hydrolysis Effects 0.000 claims 3
- 238000006460 hydrolysis reaction Methods 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 238000009835 boiling Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000007522 mineralic acids Chemical class 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- CNMIPBGVODYLIH-UHFFFAOYSA-N [3-methoxy-4-(4-oxo-5,6-dihydroimidazo[4,5-c]pyridin-2-yl)phenyl] methanesulfonate Chemical compound COC1=CC(OS(C)(=O)=O)=CC=C1C1=NC2=CCNC(=O)C2=N1 CNMIPBGVODYLIH-UHFFFAOYSA-N 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- UKTFBYCJQQKDDX-UHFFFAOYSA-N imidazo[4,5-b]pyrazin-5-one Chemical compound O=C1C=NC2=NC=NC2=N1 UKTFBYCJQQKDDX-UHFFFAOYSA-N 0.000 claims 1
- BSMNACCHROZNHW-UHFFFAOYSA-N imidazo[4,5-b]pyridin-5-one Chemical compound O=C1C=CC2=NC=NC2=N1 BSMNACCHROZNHW-UHFFFAOYSA-N 0.000 claims 1
- FIJNUMPUCGUJLV-UHFFFAOYSA-N imidazo[4,5-c]pyridazin-6-one Chemical compound C1=CN=NC2=NC(=O)N=C21 FIJNUMPUCGUJLV-UHFFFAOYSA-N 0.000 claims 1
- PPNFWYUJXHAZIN-UHFFFAOYSA-N imidazo[4,5-c]pyridin-4-one Chemical compound O=C1N=CC=C2N=CN=C12 PPNFWYUJXHAZIN-UHFFFAOYSA-N 0.000 claims 1
- KVOVCEPPQJRTOB-UHFFFAOYSA-N imidazo[4,5-d]pyridazin-4-one Chemical compound O=C1N=NC=C2N=CN=C12 KVOVCEPPQJRTOB-UHFFFAOYSA-N 0.000 claims 1
- YFFVDIZCICRYFW-UHFFFAOYSA-N imidazo[4,5-d]triazin-6-one Chemical compound C1=NN=NC2=NC(=O)N=C21 YFFVDIZCICRYFW-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- UFZNZKGKBWOSJG-UHFFFAOYSA-N purin-2-one Chemical compound O=C1N=CC2=NC=NC2=N1 UFZNZKGKBWOSJG-UHFFFAOYSA-N 0.000 claims 1
- UYLWKSJTHLRFBX-UHFFFAOYSA-N purin-6-one Chemical compound O=C1N=CN=C2N=CN=C12 UYLWKSJTHLRFBX-UHFFFAOYSA-N 0.000 claims 1
- FAIAJSOSTNJZCI-UHFFFAOYSA-N purine-2,6-dione Chemical compound O=C1NC(=O)C2=NC=NC2=N1 FAIAJSOSTNJZCI-UHFFFAOYSA-N 0.000 claims 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 150000003461 sulfonyl halides Chemical class 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833324115 DE3324115A1 (de) | 1983-07-05 | 1983-07-05 | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DEP3324115.5 | 1983-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850001208A true KR850001208A (ko) | 1985-03-16 |
Family
ID=6203136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840003852A Withdrawn KR850001208A (ko) | 1983-07-05 | 1984-07-04 | 이미다졸 유도체의 제조방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4670438A (en:Method) |
| EP (1) | EP0130461A3 (en:Method) |
| JP (1) | JPS6036486A (en:Method) |
| KR (1) | KR850001208A (en:Method) |
| AU (1) | AU3032384A (en:Method) |
| DD (1) | DD224851A5 (en:Method) |
| DE (1) | DE3324115A1 (en:Method) |
| DK (1) | DK326484A (en:Method) |
| ES (4) | ES533995A0 (en:Method) |
| FI (1) | FI842666A7 (en:Method) |
| GR (1) | GR82380B (en:Method) |
| HU (1) | HU194878B (en:Method) |
| IL (1) | IL72298A0 (en:Method) |
| NO (1) | NO842684L (en:Method) |
| NZ (1) | NZ208779A (en:Method) |
| PH (1) | PH21496A (en:Method) |
| PT (1) | PT78836B (en:Method) |
| ZA (1) | ZA845103B (en:Method) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346640A1 (de) * | 1983-12-23 | 1985-07-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3445299A1 (de) * | 1984-12-12 | 1986-06-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3522230A1 (de) * | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US4783530A (en) * | 1986-11-13 | 1988-11-08 | Marion Laboratories, Inc. | 8-arylxanthines |
| GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
| DE3929864A1 (de) * | 1989-09-08 | 1991-03-14 | Nordmark Arzneimittel Gmbh | Verfahren zur herstellung von theophyllin-pellets |
| EP0434038A1 (en) * | 1989-12-22 | 1991-06-26 | Takeda Chemical Industries, Ltd. | Fused imidazole derivatives, their production and use |
| US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| JP2534423B2 (ja) * | 1991-12-26 | 1996-09-18 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤 |
| EP0577025A3 (de) * | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen |
| FI953981A0 (fi) * | 1993-02-26 | 1995-08-24 | Schering Corp | 2-Bentsyyli-polysykliset guaniinijohdannaiset ja menetelmä niiden valmistamiseksi |
| CA2131134A1 (en) * | 1993-09-17 | 1995-03-18 | Gerhard Stucky | Process for preparing imidazopyridine derivatives |
| CA2131680C (en) * | 1993-09-17 | 2006-11-07 | Gerhard Stucky | Process for preparing imidazopyridine derivatives |
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| US6887690B2 (en) * | 2001-06-22 | 2005-05-03 | Pe Corporation | Dye-labeled ribonucleotide triphosphates |
| JP4127204B2 (ja) * | 2003-12-17 | 2008-07-30 | セイコーエプソン株式会社 | 液晶表示装置の製造方法 |
| US8168658B2 (en) * | 2006-02-28 | 2012-05-01 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
| US8461189B2 (en) * | 2007-06-27 | 2013-06-11 | Merck Sharp & Dohme Corp. | Pyridyl derivatives as histone deacetylase inhibitors |
| JP5501227B2 (ja) | 2007-06-27 | 2014-05-21 | メルク・シャープ・アンド・ドーム・コーポレーション | ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体 |
| US20090197880A1 (en) * | 2007-07-13 | 2009-08-06 | Genelabs Technologies, Inc. | Anti-viral compounds, compositions, and methods of use |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3660397A (en) * | 1970-04-17 | 1972-05-02 | Merck & Co Inc | Imidazo(4 5-b)pyrazines |
| US3922345A (en) * | 1971-10-29 | 1975-11-25 | Pfizer | Pyrimidinones and hydroxy pyrimidines |
| US3985891A (en) * | 1973-02-03 | 1976-10-12 | Boehringer Ingelheim Gmbh | 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof |
| DE2305339C3 (de) * | 1973-02-03 | 1980-05-08 | Dr. Karl Thomae Gmbh, 7950 Biberach | Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica |
| EP0011399A1 (en) * | 1978-11-11 | 1980-05-28 | FISONS plc | N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them |
| DE2927988A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel |
| DE2927987A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel |
| DE3037464A1 (de) * | 1980-10-03 | 1982-05-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | 6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel |
| DE3044497A1 (de) * | 1980-11-26 | 1982-06-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neues verfahren zur herstellung von imidazo(4,5-b)pyridinen und -pyrimidinen |
| GB2091249A (en) * | 1980-12-23 | 1982-07-28 | Fordonal Sa | Xanthine derivatives |
| EP0072926B1 (de) * | 1981-08-19 | 1986-09-24 | MERCK PATENT GmbH | 2-Aryl-imidazopyridine |
| ES8401486A1 (es) * | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
| US4452788A (en) * | 1982-04-21 | 1984-06-05 | Warner-Lambert Company | Substituted 8-phenylxanthines |
| RO86850B (ro) * | 1982-05-03 | 1985-05-31 | Eli Lilly And Company | Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine |
| DE3217583A1 (de) * | 1982-05-11 | 1983-11-17 | Merck Patent Gmbh, 6100 Darmstadt | 2-aryl-tetraazaindene |
| DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
-
1983
- 1983-07-05 DE DE19833324115 patent/DE3324115A1/de not_active Withdrawn
-
1984
- 1984-06-19 EP EP84107002A patent/EP0130461A3/de not_active Withdrawn
- 1984-06-22 US US06/623,718 patent/US4670438A/en not_active Expired - Fee Related
- 1984-06-29 PH PH30905A patent/PH21496A/en unknown
- 1984-07-02 GR GR75159A patent/GR82380B/el unknown
- 1984-07-03 DK DK326484A patent/DK326484A/da not_active Application Discontinuation
- 1984-07-03 FI FI842666A patent/FI842666A7/fi not_active Application Discontinuation
- 1984-07-03 PT PT78836A patent/PT78836B/pt unknown
- 1984-07-03 NO NO842684A patent/NO842684L/no unknown
- 1984-07-03 DD DD84264889A patent/DD224851A5/de unknown
- 1984-07-04 HU HU842616A patent/HU194878B/hu unknown
- 1984-07-04 KR KR1019840003852A patent/KR850001208A/ko not_active Withdrawn
- 1984-07-04 ZA ZA845103A patent/ZA845103B/xx unknown
- 1984-07-04 NZ NZ208779A patent/NZ208779A/en unknown
- 1984-07-04 JP JP59137395A patent/JPS6036486A/ja active Pending
- 1984-07-04 ES ES533995A patent/ES533995A0/es active Granted
- 1984-07-04 IL IL72298A patent/IL72298A0/xx unknown
- 1984-07-05 AU AU30323/84A patent/AU3032384A/en not_active Abandoned
-
1985
- 1985-03-28 ES ES541662A patent/ES8603480A1/es not_active Expired
- 1985-03-28 ES ES541660A patent/ES8603478A1/es not_active Expired
- 1985-03-28 ES ES541661A patent/ES541661A0/es active Granted
-
1987
- 1987-01-28 US US07/007,530 patent/US4766130A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA845103B (en) | 1986-03-26 |
| US4766130A (en) | 1988-08-23 |
| NO842684L (no) | 1985-01-07 |
| ES541660A0 (es) | 1985-12-16 |
| DK326484D0 (da) | 1984-07-03 |
| GR82380B (en:Method) | 1984-12-13 |
| FI842666A0 (fi) | 1984-07-03 |
| DD224851A5 (de) | 1985-07-17 |
| AU3032384A (en) | 1985-01-10 |
| ES541662A0 (es) | 1985-12-16 |
| DE3324115A1 (de) | 1985-01-17 |
| DK326484A (da) | 1985-01-06 |
| IL72298A0 (en) | 1984-11-30 |
| FI842666A7 (fi) | 1985-01-06 |
| ES8506017A1 (es) | 1985-06-16 |
| ES533995A0 (es) | 1985-06-16 |
| ES8603480A1 (es) | 1985-12-16 |
| PH21496A (en) | 1987-11-10 |
| NZ208779A (en) | 1988-02-29 |
| ES8603479A1 (es) | 1985-12-16 |
| ES541661A0 (es) | 1985-12-16 |
| JPS6036486A (ja) | 1985-02-25 |
| HU194878B (en) | 1988-03-28 |
| PT78836B (de) | 1986-10-21 |
| EP0130461A2 (de) | 1985-01-09 |
| HUT34475A (en) | 1985-03-28 |
| US4670438A (en) | 1987-06-02 |
| ES8603478A1 (es) | 1985-12-16 |
| EP0130461A3 (de) | 1987-05-06 |
| PT78836A (de) | 1984-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR850001208A (ko) | 이미다졸 유도체의 제조방법 | |
| TW575573B (en) | Substituted 6,5-hetero-bicyclic derivatives | |
| FI64594B (fi) | Foerfarande foer framstaellning av antiallergiska 3-(1h-tetrazol-5-yl)-4-pyrido(1,2-a)pyrimidin-4-onderivat | |
| KR840005432A (ko) | 이미다졸 유도체의 제조방법 | |
| US5866702A (en) | Purine inhibitors of cyclin dependent kinase 2 | |
| KR880005127A (ko) | 이미다조 피리딘 유도체 및 이의 제조방법 | |
| US20020151713A1 (en) | Substituted 6,5-hetero-bicyclic derivatives | |
| KR930000514A (ko) | 7-아자이소인돌리닐-퀴놀론- 및 -나프티리돈카르복실산 유도체 | |
| KR930007949A (ko) | 치환된 피리미딘, 이의 제조 방법, 이를 함유하는 약제학적 조성물 및 이의 용도 | |
| KR880012605A (ko) | 피라졸로[3,4-d]피리미딘, 이들의 제조방법 및 이들을 함유하는 제약조성물 | |
| KR870004030A (ko) | 축합 이미다조 피리딘 유도체 | |
| GB2069481B (en) | Substituted imidazole derivatives | |
| DK1165560T3 (da) | 2-Hydroxymethylcyclopropylidenmethylpuriner som antivirale midler | |
| KR890004700A (ko) | 포스포디에스테라제 억제제 및 트롬복산 a_2 길항제로 구성된 상승 작용성 배합물 이의 용도 및 이의 제조방법 | |
| KR950032193A (ko) | 5,6-디히드로-4H-이미다조[2',1':2,3]이미다조[4, 5, 1-ij]퀴놀린 및 4,5-디히드로이미다조[1,2-a]피롤로[1,2,3-cd]벤즈이미다졸 유도체와 그것의 제법 및 치료에의 이용 | |
| KR880001595A (ko) | 4- 피리돈 유도체, 이의 제조방법 및 약제학적 조성물 | |
| ATE34743T1 (de) | Substituierte phenyl-2-(1h)-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen. | |
| KR850004467A (ko) | 벤즈이미다졸 유도체의 제조방법 | |
| KR840005137A (ko) | 티오포름아미드 유도체의 제조방법 | |
| KR840001968A (ko) | 4-페닐퀴나졸린 유도체의 제조방법 | |
| KR830010134A (ko) | 전기활성 중합체의 제조방법 | |
| MX7118E (es) | Procedimiento para preparar derivados de imidazol(1,2-a)quinoleina | |
| KR910006285A (ko) | 축합 디아제피논, 이의 제조방법 및 이를 함유하는 약제 | |
| Barlin et al. | A carbon-13 nuclear magnetic resonance study of protonation in Imidazo [4, 5-c] pyridines | |
| ES2076056T3 (es) | Procedimiento para la obtencion de piezas moldeadas niqueladas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19840704 |
|
| PG1501 | Laying open of application | ||
| PC1202 | Submission of document of withdrawal before decision of registration |
Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment) Patent event code: PC12021R01D Patent event date: 19890704 |
|
| WITB | Written withdrawal of application |