ES8603478A1 - Procedimiento para preparar nuevos imidazoles - Google Patents
Procedimiento para preparar nuevos imidazolesInfo
- Publication number
- ES8603478A1 ES8603478A1 ES541660A ES541660A ES8603478A1 ES 8603478 A1 ES8603478 A1 ES 8603478A1 ES 541660 A ES541660 A ES 541660A ES 541660 A ES541660 A ES 541660A ES 8603478 A1 ES8603478 A1 ES 8603478A1
- Authority
- ES
- Spain
- Prior art keywords
- imidazoles
- compounds
- preparation
- ch2o
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS IMIDAZOLES. COMPRENDE: A) TRANSPONER UNN-OXIDO DE FORMULA (II) PARA OBTENER UN COMPUESTO DE FORMULA (I), EN UN DISOLVENTE, EN PRESENCIA DE UN AGENTE ACILANTE Y A TEMPERATURAS ELEVADAS, PRIORITARIAMENTE A LA TEMPERATURA DE EBULLICION DE LA MEZCLA DE REACCION; B) OPCIONALMENTE EL PRODUCTO DE A) ES HIDROLIZADO EN PRESENCIA DE UN ACIDO O DE UNA BASE; Y C) TRANSFORMAR EL COMPUESTO DE FORMULA (I) EN SU SAL POR ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLE CON UN ACIDO INORGANICO U ORGANICO. SIENDO: A, B, C Y D, CADA UNO, UN GRUPO N, HN, R3N OFC,HC Y OTROS, COMBINADOS SEGUN LAS RESTRICCIONES QUE SE INDICAN; R1 ES UN GRUPO NC-CH2-O,R3-OOC-CH2-O Y OTROS; R2 ES UN GRUPO DE FORMULA (I); R4 ES UN GRUPO ALQUINILO O ALQUENILO; R5FR4. SE UTILIZAN POR SU EFECTO DE CONTRACTILIDAD DEL MUSCULO CARDIACO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833324115 DE3324115A1 (de) | 1983-07-05 | 1983-07-05 | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES541660A0 ES541660A0 (es) | 1985-12-16 |
ES8603478A1 true ES8603478A1 (es) | 1985-12-16 |
Family
ID=6203136
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533995A Expired ES8506017A1 (es) | 1983-07-05 | 1984-07-04 | Procedimiento para preparar imidasoles |
ES541660A Expired ES8603478A1 (es) | 1983-07-05 | 1985-03-28 | Procedimiento para preparar nuevos imidazoles |
ES541662A Granted ES541662A0 (es) | 1983-07-05 | 1985-03-28 | Procedimiento para preparar nuevos imidazoles |
ES541661A Expired ES8603479A1 (es) | 1983-07-05 | 1985-03-28 | Procedimiento para preparar nuevos imidazoles |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533995A Expired ES8506017A1 (es) | 1983-07-05 | 1984-07-04 | Procedimiento para preparar imidasoles |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541662A Granted ES541662A0 (es) | 1983-07-05 | 1985-03-28 | Procedimiento para preparar nuevos imidazoles |
ES541661A Expired ES8603479A1 (es) | 1983-07-05 | 1985-03-28 | Procedimiento para preparar nuevos imidazoles |
Country Status (18)
Country | Link |
---|---|
US (2) | US4670438A (es) |
EP (1) | EP0130461A3 (es) |
JP (1) | JPS6036486A (es) |
KR (1) | KR850001208A (es) |
AU (1) | AU3032384A (es) |
DD (1) | DD224851A5 (es) |
DE (1) | DE3324115A1 (es) |
DK (1) | DK326484A (es) |
ES (4) | ES8506017A1 (es) |
FI (1) | FI842666A (es) |
GR (1) | GR82380B (es) |
HU (1) | HU194878B (es) |
IL (1) | IL72298A0 (es) |
NO (1) | NO842684L (es) |
NZ (1) | NZ208779A (es) |
PH (1) | PH21496A (es) |
PT (1) | PT78836B (es) |
ZA (1) | ZA845103B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3346640A1 (de) * | 1983-12-23 | 1985-07-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3445299A1 (de) * | 1984-12-12 | 1986-06-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DE3522230A1 (de) * | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US4783530A (en) * | 1986-11-13 | 1988-11-08 | Marion Laboratories, Inc. | 8-arylxanthines |
GB8804016D0 (en) * | 1988-02-22 | 1988-03-23 | Boots Co Plc | Therapeutic agents |
DE3929864A1 (de) * | 1989-09-08 | 1991-03-14 | Nordmark Arzneimittel Gmbh | Verfahren zur herstellung von theophyllin-pellets |
EP0434038A1 (en) * | 1989-12-22 | 1991-06-26 | Takeda Chemical Industries, Ltd. | Fused imidazole derivatives, their production and use |
US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
JP2534423B2 (ja) * | 1991-12-26 | 1996-09-18 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤 |
EP0577025A3 (de) * | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen |
CA2156918A1 (en) * | 1993-02-26 | 1994-09-01 | Deen Tulshian | 2-benzyl-polycyclic guanine derivatives and process for preparing them |
CA2131680C (en) * | 1993-09-17 | 2006-11-07 | Gerhard Stucky | Process for preparing imidazopyridine derivatives |
CA2131134A1 (en) * | 1993-09-17 | 1995-03-18 | Gerhard Stucky | Process for preparing imidazopyridine derivatives |
US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
US6887690B2 (en) * | 2001-06-22 | 2005-05-03 | Pe Corporation | Dye-labeled ribonucleotide triphosphates |
JP4127204B2 (ja) * | 2003-12-17 | 2008-07-30 | セイコーエプソン株式会社 | 液晶表示装置の製造方法 |
JP2009528354A (ja) * | 2006-02-28 | 2009-08-06 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素のインヒビター |
US8461189B2 (en) * | 2007-06-27 | 2013-06-11 | Merck Sharp & Dohme Corp. | Pyridyl derivatives as histone deacetylase inhibitors |
US8389553B2 (en) * | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
US20090197880A1 (en) * | 2007-07-13 | 2009-08-06 | Genelabs Technologies, Inc. | Anti-viral compounds, compositions, and methods of use |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660397A (en) * | 1970-04-17 | 1972-05-02 | Merck & Co Inc | Imidazo(4 5-b)pyrazines |
US3922345A (en) * | 1971-10-29 | 1975-11-25 | Pfizer | Pyrimidinones and hydroxy pyrimidines |
US3985891A (en) * | 1973-02-03 | 1976-10-12 | Boehringer Ingelheim Gmbh | 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof |
DE2305339C3 (de) * | 1973-02-03 | 1980-05-08 | Dr. Karl Thomae Gmbh, 7950 Biberach | Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica |
EP0011399A1 (en) * | 1978-11-11 | 1980-05-28 | FISONS plc | N-substituted theophyllines, processes for their preparation and pharmaceutical compositions containing them |
DE2927988A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel |
DE2927987A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel |
DE3037464A1 (de) * | 1980-10-03 | 1982-05-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | 6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel |
DE3044497A1 (de) * | 1980-11-26 | 1982-06-24 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neues verfahren zur herstellung von imidazo(4,5-b)pyridinen und -pyrimidinen |
GB2091249A (en) * | 1980-12-23 | 1982-07-28 | Fordonal Sa | Xanthine derivatives |
DE3273461D1 (en) * | 1981-08-19 | 1986-10-30 | Merck Patent Gmbh | 2-arylimidazopyridines |
ES8401486A1 (es) * | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
US4452788A (en) * | 1982-04-21 | 1984-06-05 | Warner-Lambert Company | Substituted 8-phenylxanthines |
RO86850B (ro) * | 1982-05-03 | 1985-05-31 | Eli Lilly And Company | Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine |
DE3217583A1 (de) * | 1982-05-11 | 1983-11-17 | Merck Patent Gmbh, 6100 Darmstadt | 2-aryl-tetraazaindene |
DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
-
1983
- 1983-07-05 DE DE19833324115 patent/DE3324115A1/de not_active Withdrawn
-
1984
- 1984-06-19 EP EP84107002A patent/EP0130461A3/de not_active Withdrawn
- 1984-06-22 US US06/623,718 patent/US4670438A/en not_active Expired - Fee Related
- 1984-06-29 PH PH30905A patent/PH21496A/en unknown
- 1984-07-02 GR GR75159A patent/GR82380B/el unknown
- 1984-07-03 DK DK326484A patent/DK326484A/da not_active Application Discontinuation
- 1984-07-03 FI FI842666A patent/FI842666A/fi not_active Application Discontinuation
- 1984-07-03 DD DD84264889A patent/DD224851A5/de unknown
- 1984-07-03 PT PT78836A patent/PT78836B/pt unknown
- 1984-07-03 NO NO842684A patent/NO842684L/no unknown
- 1984-07-04 ZA ZA845103A patent/ZA845103B/xx unknown
- 1984-07-04 NZ NZ208779A patent/NZ208779A/en unknown
- 1984-07-04 KR KR1019840003852A patent/KR850001208A/ko not_active Application Discontinuation
- 1984-07-04 JP JP59137395A patent/JPS6036486A/ja active Pending
- 1984-07-04 IL IL72298A patent/IL72298A0/xx unknown
- 1984-07-04 HU HU842616A patent/HU194878B/hu unknown
- 1984-07-04 ES ES533995A patent/ES8506017A1/es not_active Expired
- 1984-07-05 AU AU30323/84A patent/AU3032384A/en not_active Abandoned
-
1985
- 1985-03-28 ES ES541660A patent/ES8603478A1/es not_active Expired
- 1985-03-28 ES ES541662A patent/ES541662A0/es active Granted
- 1985-03-28 ES ES541661A patent/ES8603479A1/es not_active Expired
-
1987
- 1987-01-28 US US07/007,530 patent/US4766130A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4670438A (en) | 1987-06-02 |
EP0130461A2 (de) | 1985-01-09 |
JPS6036486A (ja) | 1985-02-25 |
PH21496A (en) | 1987-11-10 |
DE3324115A1 (de) | 1985-01-17 |
NZ208779A (en) | 1988-02-29 |
ZA845103B (en) | 1986-03-26 |
FI842666A0 (fi) | 1984-07-03 |
IL72298A0 (en) | 1984-11-30 |
NO842684L (no) | 1985-01-07 |
DD224851A5 (de) | 1985-07-17 |
ES541661A0 (es) | 1985-12-16 |
PT78836B (de) | 1986-10-21 |
AU3032384A (en) | 1985-01-10 |
ES541660A0 (es) | 1985-12-16 |
ES533995A0 (es) | 1985-06-16 |
ES8603480A1 (es) | 1985-12-16 |
US4766130A (en) | 1988-08-23 |
DK326484A (da) | 1985-01-06 |
ES8506017A1 (es) | 1985-06-16 |
EP0130461A3 (de) | 1987-05-06 |
ES8603479A1 (es) | 1985-12-16 |
GR82380B (es) | 1984-12-13 |
KR850001208A (ko) | 1985-03-16 |
HUT34475A (en) | 1985-03-28 |
DK326484D0 (da) | 1984-07-03 |
FI842666A (fi) | 1985-01-06 |
HU194878B (en) | 1988-03-28 |
ES541662A0 (es) | 1985-12-16 |
PT78836A (de) | 1984-08-01 |
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