RO86850B - Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine - Google Patents

Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine

Info

Publication number
RO86850B
RO86850B RO110784A RO11078483A RO86850B RO 86850 B RO86850 B RO 86850B RO 110784 A RO110784 A RO 110784A RO 11078483 A RO11078483 A RO 11078483A RO 86850 B RO86850 B RO 86850B
Authority
RO
Romania
Prior art keywords
alkoxy
alkylsulfonyl
alkyl
group
substituted
Prior art date
Application number
RO110784A
Other languages
English (en)
Other versions
RO86850A (ro
Inventor
David Wayne Robertson
James Scott Hayes
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO86850A publication Critical patent/RO86850A/ro
Publication of RO86850B publication Critical patent/RO86850B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Inventia se refera la un procedeu pentru prepararea unor 2-fenilimifazo (4,5 c) piridine cu formula I sau Ia: (vezi formula) în care R1 este H, o grupa alchil cu 1...4 C sau Cl, R2 si R3 reprezinta independent H, alchil cu 1...4 C, alcoxi cu 1...4 C, alchilsulfinil cu 1...4 C, alchilsulfonil cu 1...4 C, hidroxi, halogen, cian, nitro, amino, mono- sau di(alchil cu 1...4 C)-amino, trifluormetil sau alcoxi cu 1...4 C substituit cu o grupa Z-Q- în care Q esre 0, sulfinil, sulfonil sau o grupa covalenta si Z este alchil cu 1...4 C fenil sau fenil substituit cu haligen, alchil cu 1...4 C, alcoxi cu 1...4 C, hidroxi, nitro, amino, alchilsulfonil cu 1...4 C, sau alchilsulfonil cu 1...4 C, cu conditia ca cel putin unul din R2 si R3 sa fie alchil-sulfinil cu 1...4 C alchilsulfonil cu 1...4 C sau alcoxi cu 1...4 C substituit cu o grupa Z-Q-, în care Q este sulfinil cu 1...4 C sa alchilsulfonil cu 1...4 C sau alcoxi cu 1...4 C. Procedeul de preparea consta în tratarea compusilor cu formula II sau IIa: (vezi formula) în care cel putin unul dion radicalii R5 si R6 sa fie alchiltio sau alcoxi substituit cu o grupa Z-Q-, în care Q este sulf si Z este fenil substituit cu alchiltio si celalalt radical are semnificatiile lui R2 si R3 cu agenti de oxidare alesi dintre acid m-clor-perbenzoic,
RO110784A 1982-05-03 1983-04-26 Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine RO86850B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37393282A 1982-05-03 1982-05-03

Publications (2)

Publication Number Publication Date
RO86850A RO86850A (ro) 1985-05-20
RO86850B true RO86850B (ro) 1985-05-31

Family

ID=23474501

Family Applications (1)

Application Number Title Priority Date Filing Date
RO110784A RO86850B (ro) 1982-05-03 1983-04-26 Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine

Country Status (19)

Country Link
EP (1) EP0093593A3 (ro)
JP (1) JPS58203991A (ro)
KR (1) KR840004748A (ro)
AU (1) AU1410983A (ro)
DD (1) DD210273A5 (ro)
DK (1) DK194183A (ro)
EG (1) EG16037A (ro)
FI (1) FI831437L (ro)
GB (1) GB2119377B (ro)
GR (1) GR78253B (ro)
HU (1) HU189652B (ro)
IL (1) IL68495A0 (ro)
MY (1) MY8700792A (ro)
NZ (1) NZ204022A (ro)
PH (1) PH19246A (ro)
PL (1) PL241757A1 (ro)
PT (1) PT76607B (ro)
RO (1) RO86850B (ro)
ZA (1) ZA832938B (ro)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
CA1271477A (en) * 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinolin-4-amines
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
GR850426B (ro) * 1984-02-24 1985-06-18 Lilly Co Eli
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1295330C (en) * 1985-03-29 1992-02-04 James M. Greene Synthesis of inotropic imidazo(4,5-c) pyridine
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
EP0322149A2 (en) * 1987-12-22 1989-06-28 Eli Lilly And Company Hydrates of an inotropic agent
US5019581A (en) * 1988-03-14 1991-05-28 G. D. Searle & Co. 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US4988707A (en) * 1989-09-13 1991-01-29 G. D. Searle & Co. Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines
WO2001096336A2 (en) * 2000-06-14 2001-12-20 Warner-Lambert Company 6,5-fused bicyclic heterocycles
CN100338040C (zh) * 2001-11-16 2007-09-19 日本化学医药株式会社 黄嘌呤氧化酶抑制化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI58126C (fi) * 1973-02-03 1980-12-10 Thomae Gmbh Dr K Foerfarande foer framstaellning av kardiotona och blodtryckssaenkande 2-fenyl-1h-imidatso(4,5-b)pyridiner
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Also Published As

Publication number Publication date
ZA832938B (en) 1984-12-24
GB8311819D0 (en) 1983-06-02
EG16037A (en) 1986-12-30
GB2119377A (en) 1983-11-16
JPS58203991A (ja) 1983-11-28
FI831437L (fi) 1983-11-04
NZ204022A (en) 1986-03-14
GB2119377B (en) 1985-10-09
RO86850A (ro) 1985-05-20
DD210273A5 (de) 1984-06-06
KR840004748A (ko) 1984-10-24
PT76607B (en) 1986-03-12
PH19246A (en) 1986-02-14
IL68495A0 (en) 1983-07-31
DK194183D0 (da) 1983-05-02
FI831437A0 (fi) 1983-04-27
PL241757A1 (en) 1985-02-13
EP0093593A2 (en) 1983-11-09
GR78253B (ro) 1984-09-26
HU189652B (en) 1986-07-28
AU1410983A (en) 1983-11-10
MY8700792A (en) 1987-12-31
EP0093593A3 (en) 1984-07-25
DK194183A (da) 1983-11-04
PT76607A (en) 1983-05-01

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