DK194183A - Fremgangsmaade til fremstilling af 2-phenyl-imidazo(4,5-c)pyridiner - Google Patents

Fremgangsmaade til fremstilling af 2-phenyl-imidazo(4,5-c)pyridiner Download PDF

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Publication number
DK194183A
DK194183A DK194183A DK194183A DK194183A DK 194183 A DK194183 A DK 194183A DK 194183 A DK194183 A DK 194183A DK 194183 A DK194183 A DK 194183A DK 194183 A DK194183 A DK 194183A
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DK
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Prior art keywords
phenyl
pyridines
imidazo
preparing
alkoxy
Prior art date
Application number
DK194183A
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English (en)
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DK194183D0 (da
Inventor
David Wayne Robertson
James Scott Hayes
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK194183D0 publication Critical patent/DK194183D0/da
Publication of DK194183A publication Critical patent/DK194183A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

allyloxy, C^-C^alkylthio, C^-C^-alkylsulfinyl, C^-C^-alkylsulfonyl, hydroxy, halogen, cyano, nitro, amino, mono- eller di(C^-C^-alkyl)-amino, trifluormethyl eller Z-Q-substitueret C^-C^-alkoxy, hvori Q er oxygen, svovl, sulfonyl eller en binding, og Z er C^-C^-alkyl, phenyl eller substitueret phenyl, og er hydrogen, C^-C^-alkyl eller C^-C^-aikoxy, fremstilles ved en række forskellige fremgangsmåder.
De tautomere forbindelser (I) og (la) er nyttige som positive inotrope midler med minimal virkning på blodtrykket og hjertehastigheden. Forbindelserne har endvidere antikoagulerende virkning samt vasodilations- og broncho-dilationsvirkning.
DK194183A 1982-05-03 1983-05-02 Fremgangsmaade til fremstilling af 2-phenyl-imidazo(4,5-c)pyridiner DK194183A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37393282A 1982-05-03 1982-05-03
US37393282 1982-05-03

Publications (2)

Publication Number Publication Date
DK194183D0 DK194183D0 (da) 1983-05-02
DK194183A true DK194183A (da) 1983-11-04

Family

ID=23474501

Family Applications (1)

Application Number Title Priority Date Filing Date
DK194183A DK194183A (da) 1982-05-03 1983-05-02 Fremgangsmaade til fremstilling af 2-phenyl-imidazo(4,5-c)pyridiner

Country Status (19)

Country Link
EP (1) EP0093593A3 (da)
JP (1) JPS58203991A (da)
KR (1) KR840004748A (da)
AU (1) AU1410983A (da)
DD (1) DD210273A5 (da)
DK (1) DK194183A (da)
EG (1) EG16037A (da)
FI (1) FI831437L (da)
GB (1) GB2119377B (da)
GR (1) GR78253B (da)
HU (1) HU189652B (da)
IL (1) IL68495A0 (da)
MY (1) MY8700792A (da)
NZ (1) NZ204022A (da)
PH (1) PH19246A (da)
PL (1) PL241757A1 (da)
PT (1) PT76607B (da)
RO (1) RO86850B (da)
ZA (1) ZA832938B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
CA1271477A (en) * 1983-11-18 1990-07-10 John F. Gerster 1h-imidazo[4,5-c]quinolin-4-amines
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL78241A0 (en) * 1985-03-29 1986-07-31 Lilly Co Eli Synthesis of inotropic imidazo(4,5-c)pyridine
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
ZA889365B (en) * 1987-12-22 1990-08-29 Lilly Co Eli Hydrates of andinotropic agent
US5019581A (en) * 1988-03-14 1991-05-28 G. D. Searle & Co. 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US4988707A (en) * 1989-09-13 1991-01-29 G. D. Searle & Co. Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines
WO2001096336A2 (en) * 2000-06-14 2001-12-20 Warner-Lambert Company 6,5-fused bicyclic heterocycles
KR100919147B1 (ko) * 2001-11-16 2009-09-25 닛뽕 케미파 가부시키가이샤 크산틴 옥시다제 저해제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI58126C (fi) * 1973-02-03 1980-12-10 Thomae Gmbh Dr K Foerfarande foer framstaellning av kardiotona och blodtryckssaenkande 2-fenyl-1h-imidatso(4,5-b)pyridiner
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Also Published As

Publication number Publication date
MY8700792A (en) 1987-12-31
JPS58203991A (ja) 1983-11-28
AU1410983A (en) 1983-11-10
KR840004748A (ko) 1984-10-24
IL68495A0 (en) 1983-07-31
PH19246A (en) 1986-02-14
GB8311819D0 (en) 1983-06-02
FI831437A0 (fi) 1983-04-27
PT76607B (en) 1986-03-12
EP0093593A3 (en) 1984-07-25
RO86850B (ro) 1985-05-31
DD210273A5 (de) 1984-06-06
PL241757A1 (en) 1985-02-13
ZA832938B (en) 1984-12-24
EP0093593A2 (en) 1983-11-09
GR78253B (da) 1984-09-26
RO86850A (ro) 1985-05-20
PT76607A (en) 1983-05-01
NZ204022A (en) 1986-03-14
FI831437L (fi) 1983-11-04
EG16037A (en) 1986-12-30
GB2119377A (en) 1983-11-16
GB2119377B (en) 1985-10-09
HU189652B (en) 1986-07-28
DK194183D0 (da) 1983-05-02

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