DK488282A - Fremgangsmaade til fremstilling af imidazolcarboxylsyrederivater - Google Patents
Fremgangsmaade til fremstilling af imidazolcarboxylsyrederivater Download PDFInfo
- Publication number
- DK488282A DK488282A DK488282A DK488282A DK488282A DK 488282 A DK488282 A DK 488282A DK 488282 A DK488282 A DK 488282A DK 488282 A DK488282 A DK 488282A DK 488282 A DK488282 A DK 488282A
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- acid derivatives
- preparing
- procedure
- hydroxy
- Prior art date
Links
- KYWMCFOWDYFYLV-UHFFFAOYSA-N 1h-imidazole-2-carboxylic acid Chemical class OC(=O)C1=NC=CN1 KYWMCFOWDYFYLV-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/317,956 US4418071A (en) | 1981-11-04 | 1981-11-04 | Cardiotonic imidazolecarboxylic acid derivatives |
| US31795681 | 1981-11-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK488282A true DK488282A (da) | 1983-05-05 |
| DK163827B DK163827B (da) | 1992-04-06 |
| DK163827C DK163827C (da) | 1992-09-14 |
Family
ID=23235988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK488282A DK163827C (da) | 1981-11-04 | 1982-11-03 | Analogifremgangsmaade til fremstilling af imidazolcarboxylsyrederivater eller et farmaceutisk acceptabelt salt deraf |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4418071A (da) |
| EP (1) | EP0078545B1 (da) |
| JP (1) | JPS5885818A (da) |
| KR (1) | KR890001151B1 (da) |
| AT (1) | ATE32339T1 (da) |
| AU (1) | AU558254B2 (da) |
| CA (1) | CA1182826A (da) |
| DE (1) | DE3278074D1 (da) |
| DK (1) | DK163827C (da) |
| ES (1) | ES8402824A1 (da) |
| GB (1) | GB2112774B (da) |
| GR (1) | GR77054B (da) |
| IE (1) | IE54121B1 (da) |
| IL (1) | IL67131A0 (da) |
| NO (1) | NO157214C (da) |
| NZ (1) | NZ202348A (da) |
| PH (1) | PH19153A (da) |
| ZA (1) | ZA827976B (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4532250A (en) * | 1983-11-23 | 1985-07-30 | American Hospital Supply Corporation | 5-Heteroarylimidazol-2-ones having cardiotonic activity |
| KR930004646B1 (ko) * | 1986-12-09 | 1993-06-02 | 다나베 세이야꾸 가부시끼가이샤 | 심기능 부전의 예방 및 치료제 |
| US4999365A (en) * | 1987-03-20 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Method of reducing reperfusion injury with imidazol-2-thiones |
| DE19858352A1 (de) | 1998-12-17 | 2000-06-21 | Basf Ag | Verfahren zum Herstellen von 2,4-Dimethyl-3,5-bis-alkoxycarbonyl-pyrrol |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2468324A (en) * | 1946-03-21 | 1949-04-26 | Hoffmann La Roche | Process for the preparation of imidazolones |
| FR1184709A (fr) * | 1957-09-21 | 1959-07-24 | Cfmc | Nouveaux dérivés imidazoliques, utilisables comme agents de protection contre les rayons ultra-violets et leurs procédés de fabrication |
| NL294421A (da) * | 1962-06-22 | |||
| US3303199A (en) * | 1963-07-15 | 1967-02-07 | Geigy Chem Corp | Certain imidazolone derivatives and process for making same |
| JPS5913511B2 (ja) * | 1975-10-11 | 1984-03-30 | 田辺製薬株式会社 | 新規イミダゾ−ル誘導体の製法 |
| JPS5283372A (en) * | 1975-12-26 | 1977-07-12 | Tanabe Seiyaku Co Ltd | Synthesis of imidazole derivatives |
| BE871675A (fr) * | 1977-12-02 | 1979-04-30 | Smithkline Corp | Procede de preparation de derives de l'imidazole |
| GB2009741B (en) | 1977-12-02 | 1982-05-12 | Smithkline Corp | Chemical process |
-
1980
- 1980-11-02 PH PH28078A patent/PH19153A/en unknown
-
1981
- 1981-11-04 US US06/317,956 patent/US4418071A/en not_active Expired - Lifetime
-
1982
- 1982-11-01 NZ NZ202348A patent/NZ202348A/en unknown
- 1982-11-01 IL IL67131A patent/IL67131A0/xx not_active IP Right Cessation
- 1982-11-01 ZA ZA827976A patent/ZA827976B/xx unknown
- 1982-11-02 GB GB08231322A patent/GB2112774B/en not_active Expired
- 1982-11-02 ES ES517039A patent/ES8402824A1/es not_active Expired
- 1982-11-02 JP JP57192019A patent/JPS5885818A/ja active Granted
- 1982-11-02 IE IE2623/82A patent/IE54121B1/en not_active IP Right Cessation
- 1982-11-02 CA CA000414706A patent/CA1182826A/en not_active Expired
- 1982-11-03 AU AU90110/82A patent/AU558254B2/en not_active Ceased
- 1982-11-03 KR KR8204949A patent/KR890001151B1/ko not_active Expired
- 1982-11-03 DK DK488282A patent/DK163827C/da not_active IP Right Cessation
- 1982-11-03 NO NO823645A patent/NO157214C/no unknown
- 1982-11-03 GR GR69717A patent/GR77054B/el unknown
- 1982-11-04 AT AT82110156T patent/ATE32339T1/de not_active IP Right Cessation
- 1982-11-04 EP EP82110156A patent/EP0078545B1/en not_active Expired
- 1982-11-04 DE DE8282110156T patent/DE3278074D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5885818A (ja) | 1983-05-23 |
| GB2112774A (en) | 1983-07-27 |
| IE54121B1 (en) | 1989-06-21 |
| JPH0465810B2 (da) | 1992-10-21 |
| KR840002359A (ko) | 1984-06-25 |
| PH19153A (en) | 1986-01-15 |
| ATE32339T1 (de) | 1988-02-15 |
| NO157214B (no) | 1987-11-02 |
| DK163827B (da) | 1992-04-06 |
| NO823645L (no) | 1983-05-05 |
| IL67131A0 (en) | 1983-03-31 |
| US4418071A (en) | 1983-11-29 |
| NO157214C (no) | 1988-02-10 |
| ES517039A0 (es) | 1984-03-01 |
| NZ202348A (en) | 1986-04-11 |
| AU9011082A (en) | 1983-05-12 |
| DK163827C (da) | 1992-09-14 |
| GR77054B (da) | 1984-09-05 |
| DE3278074D1 (de) | 1988-03-10 |
| EP0078545B1 (en) | 1988-02-03 |
| GB2112774B (en) | 1985-09-11 |
| ZA827976B (en) | 1983-09-28 |
| IE822623L (en) | 1983-05-04 |
| CA1182826A (en) | 1985-02-19 |
| KR890001151B1 (ko) | 1989-04-25 |
| ES8402824A1 (es) | 1984-03-01 |
| AU558254B2 (en) | 1987-01-22 |
| EP0078545A1 (en) | 1983-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |