DE3782938D1 - Indochinon-verbindungen. - Google Patents

Indochinon-verbindungen.

Info

Publication number
DE3782938D1
DE3782938D1 DE8787902608T DE3782938T DE3782938D1 DE 3782938 D1 DE3782938 D1 DE 3782938D1 DE 8787902608 T DE8787902608 T DE 8787902608T DE 3782938 T DE3782938 T DE 3782938T DE 3782938 D1 DE3782938 D1 DE 3782938D1
Authority
DE
Germany
Prior art keywords
group
substituted
hydrogen
alkyl group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787902608T
Other languages
English (en)
Other versions
DE3782938T2 (de
Inventor
Willem Nico Speckamp
Everardus Arnoldus Oostveen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868609369A external-priority patent/GB8609369D0/en
Priority claimed from GB868615383A external-priority patent/GB8615383D0/en
Priority claimed from GB868629049A external-priority patent/GB8629049D0/en
Application filed by Individual filed Critical Individual
Publication of DE3782938D1 publication Critical patent/DE3782938D1/de
Application granted granted Critical
Publication of DE3782938T2 publication Critical patent/DE3782938T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE87902608T 1986-04-17 1987-04-15 Indochinon-verbindungen. Expired - Fee Related DE3782938T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB868609369A GB8609369D0 (en) 1986-04-17 1986-04-17 Indoloquinone compounds
GB868615383A GB8615383D0 (en) 1986-06-24 1986-06-24 Pathways to bioactive indoletype compounds
GB868629049A GB8629049D0 (en) 1986-12-04 1986-12-04 Indoloquinone compounds

Publications (2)

Publication Number Publication Date
DE3782938D1 true DE3782938D1 (de) 1993-01-14
DE3782938T2 DE3782938T2 (de) 1993-10-21

Family

ID=27262993

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87902608T Expired - Fee Related DE3782938T2 (de) 1986-04-17 1987-04-15 Indochinon-verbindungen.

Country Status (8)

Country Link
US (1) US5079257A (de)
EP (1) EP0302874B1 (de)
JP (1) JPH0819095B2 (de)
AT (1) ATE82961T1 (de)
AU (1) AU615877B2 (de)
DE (1) DE3782938T2 (de)
DK (1) DK171079B1 (de)
WO (1) WO1987006227A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH678726A5 (de) * 1989-01-12 1991-10-31 Vni Khim Farmatsevtichesky I I
JPH0616628A (ja) * 1992-04-07 1994-01-25 Kyowa Hakko Kogyo Co Ltd インドール誘導体
WO1997023456A1 (en) * 1995-12-21 1997-07-03 British Technology Group Ltd. Indoloquinone derivatives as bioreductive agents
ES2341922T3 (es) * 2001-11-01 2010-06-29 Spectrum Pharmaceuticals, Inc. Composiciones medicas para el tratamiento intravesical de cancer de vejiga.
US8563592B2 (en) 2001-11-01 2013-10-22 Spectrum Pharmaceuticals, Inc. Bladder cancer treatment and methods
US8198302B2 (en) * 2003-02-28 2012-06-12 Oxigene, Inc. Compositions and methods with enhanced therapeutic activity
AU2006230582A1 (en) * 2005-03-31 2006-10-05 Spectrum Pharmaceuticals, Inc. Indoloquinone tumor radiation sensitization
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226385A (en) * 1963-10-11 1965-12-28 American Cyanamid Co Substituted 3-(alpha-acyloxy-lower alkyl)-4,7-indoloquinones
US3265698A (en) * 1964-08-07 1966-08-09 American Cyanamid Co Novel substituted 3-(alpha-carbamoyloxy-lower alkyl)-4, 7-indoloquinones

Also Published As

Publication number Publication date
JPH0819095B2 (ja) 1996-02-28
ATE82961T1 (de) 1992-12-15
AU615877B2 (en) 1991-10-17
WO1987006227A2 (en) 1987-10-22
EP0302874A1 (de) 1989-02-15
WO1987006227A3 (en) 1988-01-28
JPH01502906A (ja) 1989-10-05
AU7236187A (en) 1987-11-09
US5079257A (en) 1992-01-07
DK659887A (da) 1988-02-15
DK659887D0 (da) 1987-12-16
DE3782938T2 (de) 1993-10-21
DK171079B1 (da) 1996-05-28
EP0302874B1 (de) 1992-12-02

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee