MX9700339A - Derivados de azolona anti-helcobacter que contienen urea y tiourea. - Google Patents
Derivados de azolona anti-helcobacter que contienen urea y tiourea.Info
- Publication number
- MX9700339A MX9700339A MX9700339A MX9700339A MX9700339A MX 9700339 A MX9700339 A MX 9700339A MX 9700339 A MX9700339 A MX 9700339A MX 9700339 A MX9700339 A MX 9700339A MX 9700339 A MX9700339 A MX 9700339A
- Authority
- MX
- Mexico
- Prior art keywords
- 4alkyl
- compounds
- azolones
- helicobacter
- urea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invencion se refiere a los compuestos que tienen la formula (I), las sales de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas de los mismos, en donde X es O o S; Y es CH o N; R1, R2 y R3 son cada uno independientemente hidrogeno o alquilo de C1-C4; R4 y R5 son cada uno independientemente hidrogeno, halogeno, alquilo de C1-C4, alquilalcoxi de C1-C4, hidroxi, trifluorometilo, trifluorometiloxi o diflurometoloxi; R6 es alquilo de C1-C4; alquilo de C1-C4 sustituido con arilciclohexilo; arilo o arilcarbonilo; en donde arilo es fenilo opcionalmente substuido con uno o dos substituyentes seleccionados de halogeno y alquilo de C1-C4; Z es C=O o CHOH, y (1) es un radical de la formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6) o (a-7), las composiciones que comprenden dichos compuestos, procedimientos para preparar los mismos y el uso de estos compuestos como una medicina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94202017 | 1994-07-12 | ||
PCT/EP1995/002617 WO1996001820A1 (en) | 1994-07-12 | 1995-07-05 | Anti-helicobacter urea and thiourea derivatives of azolones |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9700339A true MX9700339A (es) | 1997-05-31 |
Family
ID=8217030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9700339A MX9700339A (es) | 1994-07-12 | 1995-07-05 | Derivados de azolona anti-helcobacter que contienen urea y tiourea. |
Country Status (18)
Country | Link |
---|---|
US (2) | US5639754A (es) |
JP (1) | JPH10502384A (es) |
KR (1) | KR970704738A (es) |
CN (1) | CN1071330C (es) |
AU (1) | AU684987B2 (es) |
BR (1) | BR9508378A (es) |
CA (1) | CA2194565A1 (es) |
CZ (1) | CZ2597A3 (es) |
FI (1) | FI970111A (es) |
HU (1) | HUT76647A (es) |
IL (1) | IL114535A (es) |
MX (1) | MX9700339A (es) |
NO (1) | NO970087L (es) |
NZ (1) | NZ290117A (es) |
PL (1) | PL318141A1 (es) |
SK (1) | SK4597A3 (es) |
WO (1) | WO1996001820A1 (es) |
ZA (1) | ZA955754B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639754A (en) * | 1994-07-12 | 1997-06-17 | Janssen Pharmaceutica N.V. | Urea and thiourea derivatives of azolones |
US6780880B1 (en) * | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
PL365072A1 (en) * | 2000-03-07 | 2004-12-27 | Ranbaxy Laboratories Limited | Azole compounds as therapeutic agents for fungal infections |
MXPA03000458A (es) | 2000-07-20 | 2004-06-02 | Neurogen Corp | Ligandos receptores de capsaicina. |
US7867516B2 (en) | 2001-01-29 | 2011-01-11 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
AU2004221812B2 (en) * | 2003-03-19 | 2010-02-18 | Exelixis Inc. | Tie-2 modulators and methods of use |
TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
WO2007020888A1 (ja) | 2005-08-12 | 2007-02-22 | Takeda Pharmaceutical Company Limited | 脳・神経細胞保護剤および睡眠障害治療薬 |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
PE20090362A1 (es) | 2007-06-08 | 2009-04-04 | Janssen Pharmaceutica Nv | Derivados de piperidina/piperazina como moduladores de dgat |
JP5443342B2 (ja) | 2007-06-08 | 2014-03-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン/ピペラジン誘導体 |
WO2008148851A1 (en) | 2007-06-08 | 2008-12-11 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
PT2222636E (pt) | 2007-12-21 | 2013-07-16 | Ligand Pharm Inc | Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações |
WO2009147170A2 (en) | 2008-06-05 | 2009-12-10 | Janssen Pharmaceutica Nv | Drug combinations comprising a dgat inhibitor and a ppar-agonist |
JP6130827B2 (ja) | 2011-05-17 | 2017-05-17 | 塩野義製薬株式会社 | ヘテロ環化合物 |
US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
TW218017B (es) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
TW279864B (es) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv | |
US5571811A (en) * | 1994-07-12 | 1996-11-05 | Janssen Pharmaceutica N.V. | Sulfonamide derivatives of azolones |
US5639754A (en) * | 1994-07-12 | 1997-06-17 | Janssen Pharmaceutica N.V. | Urea and thiourea derivatives of azolones |
-
1995
- 1995-05-23 US US08/448,155 patent/US5639754A/en not_active Expired - Fee Related
- 1995-07-05 SK SK45-97A patent/SK4597A3/sk unknown
- 1995-07-05 AU AU30756/95A patent/AU684987B2/en not_active Ceased
- 1995-07-05 NZ NZ290117A patent/NZ290117A/en unknown
- 1995-07-05 PL PL95318141A patent/PL318141A1/xx unknown
- 1995-07-05 BR BR9508378A patent/BR9508378A/pt not_active Application Discontinuation
- 1995-07-05 MX MX9700339A patent/MX9700339A/es unknown
- 1995-07-05 WO PCT/EP1995/002617 patent/WO1996001820A1/en not_active Application Discontinuation
- 1995-07-05 CA CA002194565A patent/CA2194565A1/en not_active Abandoned
- 1995-07-05 HU HU9700078A patent/HUT76647A/hu unknown
- 1995-07-05 CZ CZ9725A patent/CZ2597A3/cs unknown
- 1995-07-05 JP JP8504110A patent/JPH10502384A/ja active Pending
- 1995-07-05 CN CN95194024A patent/CN1071330C/zh not_active Expired - Fee Related
- 1995-07-05 KR KR1019970700088A patent/KR970704738A/ko not_active Application Discontinuation
- 1995-07-05 US US08/776,622 patent/US5811426A/en not_active Expired - Fee Related
- 1995-07-11 IL IL11453595A patent/IL114535A/xx active IP Right Grant
- 1995-07-11 ZA ZA955754A patent/ZA955754B/xx unknown
-
1997
- 1997-01-09 NO NO970087A patent/NO970087L/no not_active Application Discontinuation
- 1997-01-10 FI FI970111A patent/FI970111A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
AU3075695A (en) | 1996-02-09 |
IL114535A0 (en) | 1995-11-27 |
PL318141A1 (en) | 1997-05-12 |
NZ290117A (en) | 1997-11-24 |
CN1071330C (zh) | 2001-09-19 |
AU684987B2 (en) | 1998-01-08 |
CZ2597A3 (en) | 1997-10-15 |
CN1152309A (zh) | 1997-06-18 |
HUT76647A (en) | 1997-10-28 |
CA2194565A1 (en) | 1996-01-25 |
KR970704738A (ko) | 1997-09-06 |
SK4597A3 (en) | 1997-11-05 |
FI970111A0 (fi) | 1997-01-10 |
IL114535A (en) | 1999-04-11 |
NO970087L (no) | 1997-03-10 |
HU9700078D0 (en) | 1997-02-28 |
FI970111A (fi) | 1997-01-10 |
BR9508378A (pt) | 1997-10-28 |
US5639754A (en) | 1997-06-17 |
ZA955754B (en) | 1997-01-13 |
US5811426A (en) | 1998-09-22 |
JPH10502384A (ja) | 1998-03-03 |
NO970087D0 (no) | 1997-01-09 |
WO1996001820A1 (en) | 1996-01-25 |
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