MX9700342A - Derivados acilicos de azolonas anti-helicobacter. - Google Patents
Derivados acilicos de azolonas anti-helicobacter.Info
- Publication number
- MX9700342A MX9700342A MX9700342A MX9700342A MX9700342A MX 9700342 A MX9700342 A MX 9700342A MX 9700342 A MX9700342 A MX 9700342A MX 9700342 A MX9700342 A MX 9700342A MX 9700342 A MX9700342 A MX 9700342A
- Authority
- MX
- Mexico
- Prior art keywords
- 4alkyl
- halo
- hydrogen
- compounds
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polymerization Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La invencion se refiere a los compuestos que tienen la formula (I), las sales de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas de los mismos, en donde Y es CH o N; R1, R2 y R3 son independientemente cada uno hidrogeno o alquilo de C1-4; R4 y R5 son cada uno independientemente hidrogeno, halogeno, alquilo de C1-4, alquiloxilo de C1-4, hidroxilo, trifluorometilo, trifluorometiloxi o difluorometiloxi, R6 es hidrogeno; o R6 es fenilo substituido opcionalmente con halogeno; piridinilo; furanilo; tienilo, 3-cloro-benzo[b]tien-2-ilo; trifluorometilo; alquiloxicarbonilo de C1-4; dihalogenofenilciclopropanilo; cicloalquilo de C3-6, adamantilo; alquenilo de C2-6 substituido opcionalmente con halogenofenilo; o alquilo de C1-4 substituido opcionalmente con halogeno, fenilo, halogenofenilo, dihalogenofenilo, feniloxi, piperidinilo, pirrolidinilo, piperazinilo, alquilpiperazinilo de C1-4, alquilcarbonilpiperazinilo de C1-4, alquiloxicarbonilpiperazinilo de C1-4, ftalimino, amino, mono- o di-alquilamino de C1-20 o cicloalquilamino de C3-6; es C=O o CHOH, y (1) es un radical de formula (a-1), (a-2), (a-3), (a-4, (a-5), (a-6) o (a-7); composiciones que comprenden dichos compuestos, procedimiento para la preparacion de los mismos y el uso de estos compuestos como una medicina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94202019 | 1994-07-12 | ||
PCT/EP1995/002618 WO1996001822A1 (en) | 1994-07-12 | 1995-07-05 | Anti-helicobacter acyl derivatives of azolones |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9700342A true MX9700342A (es) | 1997-05-31 |
Family
ID=8217032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9700342A MX9700342A (es) | 1994-07-12 | 1995-07-05 | Derivados acilicos de azolonas anti-helicobacter. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5637592A (es) |
EP (1) | EP0770074A1 (es) |
JP (1) | JPH10502385A (es) |
CN (1) | CN1071331C (es) |
AU (1) | AU685310B2 (es) |
BR (1) | BR9508377A (es) |
CA (1) | CA2193490A1 (es) |
CZ (1) | CZ2897A3 (es) |
FI (1) | FI970112A (es) |
HU (1) | HUT76638A (es) |
IL (1) | IL114536A (es) |
MX (1) | MX9700342A (es) |
MY (1) | MY131727A (es) |
NO (1) | NO310290B1 (es) |
NZ (1) | NZ290118A (es) |
PH (1) | PH31455A (es) |
PL (1) | PL318140A1 (es) |
RU (1) | RU2152392C1 (es) |
SK (1) | SK4397A3 (es) |
WO (1) | WO1996001822A1 (es) |
ZA (1) | ZA955759B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
JP4960085B2 (ja) * | 2003-03-19 | 2012-06-27 | エクセリクシス, インク. | Tie−2モジュレータと使用方法 |
ZA200702645B (en) * | 2004-09-17 | 2008-08-27 | Vertex Pharma | Diaminotriazole compounds useful as protein kinase inhibitors |
AU2005286728A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
US7777036B2 (en) * | 2004-09-20 | 2010-08-17 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
CA2580856A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
AU2005286790A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD) |
AU2005286793A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes |
EP1804799B1 (en) * | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
MX2007003325A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores estearoil-coa-desaturasa. |
AR051095A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso comoinhibidores de la estearoil-coa desaturasa |
AU2005286731A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
EP2029138A1 (en) | 2005-06-03 | 2009-03-04 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
US8981094B2 (en) | 2007-06-08 | 2015-03-17 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
US8835437B2 (en) * | 2007-06-08 | 2014-09-16 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
EP2152269B1 (en) | 2007-06-08 | 2014-04-23 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
EP2801565B1 (en) * | 2013-05-06 | 2015-07-22 | King Saud University | Compounds for use as anti-ulcer agent and/or anti-Helicobacter pylori agent and pharmaceutical compositions thereof |
CA2982660C (en) | 2014-11-21 | 2023-01-24 | F2G Limited | 2-(1,5-dimethyl-3-phenyl-1h-pyrrol-2-yl)-n-(4-(4-(5-fluoropyrimidin-2-yl)piperazine-1-yl)phenyl)-2-oxoacetamide and derivatives thereof for use as antifungal agents |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
TW218017B (es) * | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
TW279864B (es) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv | |
US5571811A (en) * | 1994-07-12 | 1996-11-05 | Janssen Pharmaceutica N.V. | Sulfonamide derivatives of azolones |
-
1995
- 1995-05-23 US US08/448,082 patent/US5637592A/en not_active Expired - Fee Related
- 1995-06-02 PH PH50650A patent/PH31455A/en unknown
- 1995-07-05 CZ CZ9728A patent/CZ2897A3/cs unknown
- 1995-07-05 MX MX9700342A patent/MX9700342A/es unknown
- 1995-07-05 SK SK43-97A patent/SK4397A3/sk unknown
- 1995-07-05 NZ NZ290118A patent/NZ290118A/en unknown
- 1995-07-05 EP EP95926392A patent/EP0770074A1/en not_active Withdrawn
- 1995-07-05 WO PCT/EP1995/002618 patent/WO1996001822A1/en not_active Application Discontinuation
- 1995-07-05 RU RU97102153/04A patent/RU2152392C1/ru active
- 1995-07-05 AU AU30757/95A patent/AU685310B2/en not_active Ceased
- 1995-07-05 CA CA002193490A patent/CA2193490A1/en not_active Abandoned
- 1995-07-05 HU HU9700076A patent/HUT76638A/hu unknown
- 1995-07-05 PL PL95318140A patent/PL318140A1/xx unknown
- 1995-07-05 JP JP8504111A patent/JPH10502385A/ja active Pending
- 1995-07-05 BR BR9508377A patent/BR9508377A/pt not_active Application Discontinuation
- 1995-07-05 CN CN95194023A patent/CN1071331C/zh not_active Expired - Fee Related
- 1995-07-11 IL IL11453695A patent/IL114536A/xx active IP Right Grant
- 1995-07-11 ZA ZA955759A patent/ZA955759B/xx unknown
- 1995-07-12 MY MYPI95001970A patent/MY131727A/en unknown
-
1997
- 1997-01-09 NO NO19970088A patent/NO310290B1/no unknown
- 1997-01-10 FI FI970112A patent/FI970112A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
NZ290118A (en) | 1997-11-24 |
WO1996001822A1 (en) | 1996-01-25 |
BR9508377A (pt) | 1997-10-28 |
FI970112A0 (fi) | 1997-01-10 |
IL114536A (en) | 1999-04-11 |
HUT76638A (en) | 1997-10-28 |
CA2193490A1 (en) | 1996-01-25 |
RU2152392C1 (ru) | 2000-07-10 |
CZ2897A3 (en) | 1997-10-15 |
AU3075795A (en) | 1996-02-09 |
NO310290B1 (no) | 2001-06-18 |
NO970088L (no) | 1997-03-10 |
PL318140A1 (en) | 1997-05-12 |
SK4397A3 (en) | 1997-11-05 |
US5637592A (en) | 1997-06-10 |
JPH10502385A (ja) | 1998-03-03 |
AU685310B2 (en) | 1998-01-15 |
FI970112A (fi) | 1997-01-10 |
CN1152311A (zh) | 1997-06-18 |
HU9700076D0 (en) | 1997-02-28 |
PH31455A (en) | 1998-11-03 |
EP0770074A1 (en) | 1997-05-02 |
IL114536A0 (en) | 1995-11-27 |
NO970088D0 (no) | 1997-01-09 |
ZA955759B (en) | 1997-01-13 |
MY131727A (en) | 2007-08-30 |
CN1071331C (zh) | 2001-09-19 |
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