KR840004074A - 피리딘 또는 피란 디카복실산 유도체의 제조방법 - Google Patents
피리딘 또는 피란 디카복실산 유도체의 제조방법 Download PDFInfo
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- KR840004074A KR840004074A KR1019830000953A KR830000953A KR840004074A KR 840004074 A KR840004074 A KR 840004074A KR 1019830000953 A KR1019830000953 A KR 1019830000953A KR 830000953 A KR830000953 A KR 830000953A KR 840004074 A KR840004074 A KR 840004074A
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- Prior art keywords
- formula
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- ketoester
- organic solvent
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- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- HQGBNPXNXJHNTD-UHFFFAOYSA-N 2h-pyran-2,3-dicarboxylic acid Chemical class OC(=O)C1OC=CC=C1C(O)=O HQGBNPXNXJHNTD-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- -1 aralkyl radical Chemical class 0.000 claims 14
- 239000003960 organic solvent Substances 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000005840 aryl radicals Chemical class 0.000 claims 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- MLIREBYILWEBDM-UHFFFAOYSA-M 2-cyanoacetate Chemical compound [O-]C(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-M 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 150000003254 radicals Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 2
- QHJJSLUZWHFHTK-UHFFFAOYSA-N 3-amino-3-azaniumylidenepropanoate Chemical compound NC(=N)CC(O)=O QHJJSLUZWHFHTK-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241001124569 Lycaenidae Species 0.000 claims 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 235000014987 copper Nutrition 0.000 claims 1
- 238000010612 desalination reaction Methods 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000001725 pyrenyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 일반식(Ⅰ)중의 X가 N-R5(여기에서 R5는 후술함)이고 R2'및 R3'각각은 수소, 직쇄 또는 측쇄의 알칼라디칼, 아릴라디칼, 아르알킬 라디칼 또는 아세톡시메틸 그룹인 일반식(Ⅰ)의 화합물을 제조할 경우에는 일반식(Ⅱ')의 일리덴-β-케토에스테르를 임의로 불활성 유기 용매의 존재하에서 일반식(Ⅲ)의 엔아미노카복실레이트와 반응시키거나, 일반식(Ⅱ)'의 일리덴-β-케토에스테르를 임의로 불활성 유기 용매의 존재하에서 일반식(Ⅳ)의 아민과 일반식(Ⅴ)의 β-케토에스테르와 반응시키거나, 일반식(Ⅵ)'의 일리덴-β-케토에스테르를 임의로 불활성 유기용매의 존재하에서 일반식(Ⅶ)의 엔아미노카복실레이트와 반응시키거나, 일반식(Ⅵ)'의 일리덴-β-케토에스테르를 임의로 불활성유기 용매의 존재하에서 일반식(Ⅳ)의 아민 및 일반식(Ⅷ)의 β-케토에스테르와 반응시키거나, 일반식(Ⅸ)의 알데히드를 임의로 불활성유기용매의 존재하에서 일반식(Ⅲ)의 엔아미노카복실레이트 및 일반식(Ⅷ)의 β-케토카복실레이트와 반응시키거나, 일반식(Ⅸ)의 알데히드를 임의로 불활성유기용매의 존재하에서 일반식(Ⅶ)의 엔아미노카복실레이트 및 일반식(Ⅴ)의 β-케토카복실레이트와 반응시켜 제조하고, 일반식(Ⅰ)중의 X가 NH이고, R2또는 R3가 아미노 그룹인 일반식(Ⅰ)의 화합물을 제조할 경우에는 일반식(Ⅱ)의 일리덴-β-케토에스테르를 임의로 불활성유기 용매의 존재하에서 일반식(Ⅹ)의 아미디노 아세테이트와 반응시키거나, 일반식(Ⅵ)의 일리덴-β-케토에스테르를 임의로 불활성 유기용매의 존재하에서 일반식(XI)의 아미디노아세테이트와 반응시켜 제조하고, 일반식(Ⅰ)중의 X가 N-R5(여기에서 R5는 후술함)이고 R2또는 R3가 히드록시메틸 그룹인 일반식(Ⅰ)의 화합물을 제조할 경우에는 R2또는 R3가 아세톡시메틸인 본 발명에 따른 상응하는 화합물을 산성 또는 염기성 조건으로 가수분해시켜 아세톡시메틸 그룹을 히드록시메틸 그룹으로 전환시켜 제조하고, 일반식(Ⅰ)중의 X가 산소원자이고 R2또는 R3가 아미노 그룹인 일반식(Ⅰ)의 화합물을 제조할 경우에는 일반식(Ⅱ)의 일리덴-β-케토에스테르를 임의로 유기용매의 존재하에 일반식(XⅡ)의 시아노 아세테이트와 반응시키거나, 일반식(Ⅵ)의 일리덴-β-케토에스테르를 임의로 유기용매의 존재하에 일반식(XⅢ)의 시아노아세테이트와 반응시켜 제조하고 수득한 일반식(Ⅰ)의 화합물을 임의로 그의 부가염으로 전환시킴을 특징으로 하여 일반식(Ⅰ)의 화합물 및 약제학적으로 허용되는 그의 산부가염을 제조하는 방법.상기식에서, R은 아릴 또는 티에닐, 푸릴, 피릴, 피라졸릴, 이미다졸릴, 옥사졸릴, 이스옥사졸릴, 티아졸릴, 피리딜, 피리다지닐, 피리미딜, 피라지닐, 인돌릴, 벤즈이미다졸릴, 벤즈옥사졸릴, 벤즈이스옥사졸릴, 벤즈옥사디아졸릴, 퀴놀릴, 이소퀴놀릴, 퀸아졸릴 또는 퀸옥살릴이고 여기에서 아릴 라디칼과 헤테로 사이클은 페닐, 알킬, 알콕시, 알킬렌, 디옥시알킬렌, 할로겐, 트리플루오로메틸, 폴리플루오로알콕시, 니트로, 사아노, 아지도 또는 SOm-알킬(m=0 내지 2)로 구성된 그룹중에서 선택한 1내지 2개의 동일하거나 상이한 치환체를 임의로 함유하며, R1은 쇄중에서 하나의 산소원자가 임의로 개입될 수 있고 및/또는 할로겐, 시아노, 히드록실, 아실옥시, 페닐, 펜옥시 또는 아미노그룹(알킬, 아릴 또는 아르알킬로 구성된 그룹중에서 선택한 2개의 동일하거나 상이한 치환체로 임의 치환됨)으로 임의 치환된 직쇄, 측쇄 또는 환상의 포화 또는 불포화된 탄화수소 라디칼이며, R4는 하나의 산소원자가 임의로 개입될 수 있고 및/또는 할로겐, 히도록실 또는 아실옥시로 임의 치환된 직쇄, 측쇄 또는 환상의 포화 또는 불포화된, 탄소수 7 내지 14의 탄화수소 라디칼이고, R2및 R3는 동일하거나 상이하고 각각 수소, 직쇄 또는 측쇄의 알칼라디칼, 아릴라디칼 또는 아르알킬 라디칼이거나, 치환체 R2및 R3중의 하나가 상기한 바와 같고 다른 하나는 허드록시메틸, 아세톡시메틸 또는 아미노이며, X는 N-R5(여기에서 R5는 수소이거나, 산소원자가 임의 개입된 직쇄 또는 측쇄의 알킬라디칼, 몰폴리노알킬라디칼, 아릴라디칼 또는 아르알킬라디칼이다)이거나, X는 산소원자이고 후자의 경우 R2및 R3중의 하나는 아미노 그룹을 나타내며, R2'및 R3'는 각각 수소, 직쇄, 또는 측쇄의 알킬 라디칼, 아릴 라디칼, 아르알킬라디칼 또는 아세톡시메틸 그룹이며 일반식(Ⅱ)에서 R2는 전술된 바와 같지만 아미노 또는 히드록시 메틸 그룹은 나타내지 않으며, 일반식(Ⅵ)에서 R3는 전술된 바와 같지만 아미노 또는 히도록시 메틸그룹을 나타내지 않는다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823208628 DE3208628A1 (de) | 1982-03-10 | 1982-03-10 | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3208628.8 | 1982-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840004074A true KR840004074A (ko) | 1984-10-06 |
Family
ID=6157837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830000953A KR840004074A (ko) | 1982-03-10 | 1983-03-09 | 피리딘 또는 피란 디카복실산 유도체의 제조방법 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4622332A (ko) |
| EP (1) | EP0088276B1 (ko) |
| JP (1) | JPS58164575A (ko) |
| KR (1) | KR840004074A (ko) |
| AT (1) | ATE19513T1 (ko) |
| AU (1) | AU1214383A (ko) |
| CA (1) | CA1239401A (ko) |
| DE (2) | DE3208628A1 (ko) |
| DK (1) | DK114783A (ko) |
| ES (1) | ES520441A0 (ko) |
| FI (1) | FI830776L (ko) |
| GR (1) | GR78508B (ko) |
| IL (1) | IL68075A0 (ko) |
| NO (1) | NO830612L (ko) |
| PH (1) | PH20468A (ko) |
| PT (1) | PT76316B (ko) |
| ZA (1) | ZA831633B (ko) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0080220B1 (en) * | 1981-11-17 | 1986-02-19 | FISONS plc | Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals |
| US4414213A (en) * | 1982-03-22 | 1983-11-08 | Mead Johnson & Company | Dihydropyridyl cyclic imidate esters and their pharmaceutical use |
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| JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
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| FR2568773B1 (fr) * | 1984-08-10 | 1989-03-03 | Sandoz Lab | Nouvelles compositions pharmaceutiques administrables par voie nasale |
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| DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
| US4849436A (en) * | 1986-03-11 | 1989-07-18 | Nelson Research & Development Co. | 1,4-dihydropyridines |
| FR2596760B1 (fr) * | 1986-04-02 | 1988-12-09 | Sori Soc Rech Ind | Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique |
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| US4769382A (en) * | 1986-09-30 | 1988-09-06 | Institut Organischeskogo Sinteza Leningradsky Nauchno-Issledovatelsky Institut | Preparation for preventing and treatment of skin radiation burn lesions |
| DE3724909A1 (de) * | 1987-07-28 | 1989-02-09 | Bayer Ag | Neue substituierte nitro-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung |
| US5470982A (en) * | 1988-01-20 | 1995-11-28 | Bayer Aktiengesellschaft | Disubstituted pyridines |
| JPH01151557A (ja) * | 1988-11-15 | 1989-06-14 | Otsuka Pharmaceut Co Ltd | 降圧剤 |
| JPH02149563A (ja) * | 1988-11-30 | 1990-06-08 | Nisshin Flour Milling Co Ltd | ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法 |
| ATE146788T1 (de) * | 1992-10-30 | 1997-01-15 | Bayer Ag | 4-heterocyclophenyl substituierte dihydropyridine |
| US6001857A (en) * | 1992-10-30 | 1999-12-14 | Bayer Aktiengesellschaft | Heterocyclyl substituted dihydropyridines |
| DE4236707A1 (de) * | 1992-10-30 | 1994-05-05 | Bayer Ag | 4-Heterocyclyl substituierte Dihydropyridine |
| EE03192B1 (et) * | 1993-12-10 | 1999-06-15 | Bayer Aktiengesellschaft | Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine |
| ATE234286T1 (de) | 1993-12-10 | 2003-03-15 | Bayer Ag | Phenyl-substituierte 1,4-dihydropyridine mit cerebraler aktivität |
| DE4342193A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester |
| DE4429786A1 (de) * | 1994-08-23 | 1996-02-29 | Bayer Ag | Verwendung von substituierten 6-Amino-4H-pyranen |
| DE19529858A1 (de) * | 1995-08-14 | 1997-02-20 | Bayer Ag | Substituierte 4H-Pyrane |
| DE19529859A1 (de) * | 1995-08-14 | 1997-02-20 | Bayer Ag | Verwendung von Acyl-substituierten Aminopyranen |
| US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
| IT1283793B1 (it) * | 1996-08-23 | 1998-04-30 | Lusochimica Spa | Processo per la preparazione di diidropiridine |
| US6537504B1 (en) | 1998-04-06 | 2003-03-25 | Li Young | Method and apparatus for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds |
| US6538004B2 (en) | 2000-03-03 | 2003-03-25 | Abbott Laboratories | Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers |
| MXPA02008615A (es) * | 2000-03-03 | 2003-04-14 | Abbott Lab | Abridores de canales de potasio de dihidropirazolona triciclica y dihidroisoxazolona triciclica. |
| CN105669532B (zh) * | 2014-12-03 | 2018-11-02 | 广州市恒诺康医药科技有限公司 | 尼莫地平水溶性衍生物及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
| US3932645A (en) * | 1971-04-10 | 1976-01-13 | Farbenfabriken Bayer Ag | Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid |
| DE2210674C3 (de) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
| DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2235406C3 (de) * | 1972-07-19 | 1982-01-07 | Bayer Ag, 5090 Leverkusen | 2-Amino-4H-pyrane, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2650013C3 (de) * | 1976-10-30 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
| DE2659665A1 (de) * | 1976-12-30 | 1978-07-13 | Nattermann A & Cie | Neue 1,4-dihydropyridin-derivate |
| FI64938C (fi) * | 1977-06-20 | 1984-02-10 | Sandoz Ag | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bensoxa- och bensotiadiazolyl-1,4-dihydropyridinderivat |
| SU740768A1 (ru) * | 1977-11-21 | 1980-06-15 | Институт Органического Синтеза Ан Латвийской Сср | Способ получени эфиров 2,6-диметил1,4-дигидропиридин-3,5-дикарбоновой кислоты |
| SU725406A1 (ru) * | 1978-08-08 | 1981-07-30 | Ордена Трудового Красного Знамениинститут Органического Синтеза Ah Латвий-Ской Ccp | Эфиры диметил дигидропиридин диКАРбОНОВОй КиСлОТы,ОблАдАющиЕ АНТи-МЕТАСТАТичЕСКОй АКТиВНОСТью |
| JPS5527054A (en) * | 1978-08-15 | 1980-02-26 | Gen Foods Corp | Adsorption method |
| US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4258042A (en) * | 1980-04-11 | 1981-03-24 | Usv Pharmaceutical Corporation | Antihypertensive pyridines and compositions |
| DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| DE3042769A1 (de) * | 1980-11-13 | 1982-06-09 | Bayer Ag, 5090 Leverkusen | C-3 verknuepfte 1,4-dihydropyridine, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung |
-
1982
- 1982-03-10 DE DE19823208628 patent/DE3208628A1/de not_active Withdrawn
-
1983
- 1983-02-21 DE DE8383101626T patent/DE3363244D1/de not_active Expired
- 1983-02-21 EP EP83101626A patent/EP0088276B1/de not_active Expired
- 1983-02-21 AT AT83101626T patent/ATE19513T1/de not_active IP Right Cessation
- 1983-02-22 NO NO830612A patent/NO830612L/no unknown
- 1983-02-22 US US06/468,621 patent/US4622332A/en not_active Expired - Fee Related
- 1983-03-01 PT PT76316A patent/PT76316B/pt unknown
- 1983-03-07 IL IL68075A patent/IL68075A0/xx unknown
- 1983-03-08 AU AU12143/83A patent/AU1214383A/en not_active Abandoned
- 1983-03-08 FI FI830776A patent/FI830776L/fi not_active Application Discontinuation
- 1983-03-08 GR GR70727A patent/GR78508B/el unknown
- 1983-03-08 CA CA000423079A patent/CA1239401A/en not_active Expired
- 1983-03-09 DK DK114783A patent/DK114783A/da not_active Application Discontinuation
- 1983-03-09 PH PH28620A patent/PH20468A/en unknown
- 1983-03-09 KR KR1019830000953A patent/KR840004074A/ko not_active Application Discontinuation
- 1983-03-09 ES ES520441A patent/ES520441A0/es active Granted
- 1983-03-09 JP JP58037579A patent/JPS58164575A/ja active Pending
- 1983-03-09 ZA ZA831633A patent/ZA831633B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58164575A (ja) | 1983-09-29 |
| NO830612L (no) | 1983-09-12 |
| PT76316B (en) | 1985-11-25 |
| IL68075A0 (en) | 1983-06-15 |
| ZA831633B (en) | 1983-12-28 |
| PT76316A (en) | 1983-04-01 |
| DE3363244D1 (en) | 1986-06-05 |
| ES8401466A1 (es) | 1983-12-16 |
| FI830776L (fi) | 1983-09-11 |
| AU1214383A (en) | 1983-09-15 |
| PH20468A (en) | 1987-01-14 |
| DK114783A (da) | 1983-09-11 |
| US4622332A (en) | 1986-11-11 |
| ES520441A0 (es) | 1983-12-16 |
| EP0088276A1 (de) | 1983-09-14 |
| DK114783D0 (da) | 1983-03-09 |
| EP0088276B1 (de) | 1986-04-30 |
| CA1239401A (en) | 1988-07-19 |
| FI830776A0 (fi) | 1983-03-08 |
| DE3208628A1 (de) | 1983-09-22 |
| ATE19513T1 (de) | 1986-05-15 |
| GR78508B (ko) | 1984-09-27 |
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