KR830002875A - 모나콜린 k의 제조방법 - Google Patents
모나콜린 k의 제조방법 Download PDFInfo
- Publication number
- KR830002875A KR830002875A KR1019800001707A KR800001707A KR830002875A KR 830002875 A KR830002875 A KR 830002875A KR 1019800001707 A KR1019800001707 A KR 1019800001707A KR 800001707 A KR800001707 A KR 800001707A KR 830002875 A KR830002875 A KR 830002875A
- Authority
- KR
- South Korea
- Prior art keywords
- monascus
- sank
- ferm
- rubber
- monacolin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A22—BUTCHERING; MEAT TREATMENT; PROCESSING POULTRY OR FISH
- A22C—PROCESSING MEAT, POULTRY, OR FISH
- A22C25/00—Processing fish ; Curing of fish; Stunning of fish by electric current; Investigating fish by optical means
- A22C25/16—Removing fish-bones; Filleting fish
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 모나스쿠스 앙카(Monascus anka) SANK 10171(IFO 6540), 모나스쿠스 파아푸르스(Monascus purpureus) SANK 10271(IFO 4513), 모나스쿠스 러버(Monascus rubber) SANK 10671(FERM 4958), 모나스쿠스 비트류우스(Monascus vitreus) SANK 10960(FERM 4960), 모나스쿠스 팍시이(Monascus paxii) SANK 11172(IFO 8201), 모나스쿠스 러버 SANK 13778(FERM 4959), 모나스쿠스 러버 SANK 15177(FERM 4956) 또는 모나스쿠스 러버 SANK 18174(FERM 4957) 등의 모나스쿠스 속균 중에서 선택되는 하나 이상의 모나스쿠스 균주를 배양하여 배지로부터 모나콜린 K를 분리시키는 것을 특징으로 하는 모나콜린 K의 제조 방법.
- 상기 배양을 7내지 40℃의 온도 범위하에 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.
- 상기 배양을 20내지 30℃의 온도 범위하에 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.
- 모나스쿠스 속균이 모나스쿠스 러버 SANK 15177균주이고, 23내지 30℃의 온도 범위하에서 배양을 수행함을 특징으로 하는 특허청구의 범위 제1항 기재의 방법.
- 모나스쿠스 균주가 모나스쿠스 러버 SANK 10671(FERM 4958), 모나스쿠스 러버 SANK 13778(FERM 4959), 모나스쿠스 러버 SANK 15177(FERM 4956) 또는 모나스쿠스 러버 SANK 18174(FERM 4957) 중에서 선택됨을 특징으로 하는 모나스쿠스 속균의 순수한 생물학적 배양액.
- ※참고사항:최초출원 내용에 의하여 공개하는 것임.
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5792779A JPS55150898A (en) | 1979-05-11 | 1979-05-11 | Preparation of a new physiologically active substance mb-530b |
DK73180A DK148807C (da) | 1979-05-11 | 1980-02-20 | Fremgangsmaade til fremstilling af monacolin k |
CH136780A CH645891A5 (de) | 1979-05-11 | 1980-02-20 | Verfahren zur herstellung von monacolin k. |
DE3051097A DE3051097C2 (ko) | 1979-05-11 | 1980-02-20 | |
DE19803006215 DE3006215A1 (de) | 1979-05-11 | 1980-02-20 | Verfahren zur herstellung von monacolin k |
SE8001338A SE467975B (sv) | 1979-05-11 | 1980-02-20 | Framstaellning av monakolin k |
GB8007240A GB2049664B (en) | 1979-05-11 | 1980-03-04 | Preparation of monacolin k |
BE0/199871A BE882325A (fr) | 1979-05-11 | 1980-03-19 | Procede de preparation de la monacoline k. |
AT0148280A AT372975B (de) | 1979-05-11 | 1980-03-19 | Verfahren zum herstellen von monacolin k |
FR8006203A FR2456141A1 (fr) | 1979-05-11 | 1980-03-20 | Procede de preparation de la monacoline k |
ES489751A ES489751A0 (es) | 1979-05-11 | 1980-03-20 | Un procedimiento para la preparacion de monacolina k |
IE577/80A IE49749B1 (en) | 1979-05-11 | 1980-03-20 | Preparation of monacolin k |
CA348,220A CA1129795A (en) | 1979-05-11 | 1980-03-20 | Preparation of monacolin k |
AU56678/80A AU534647B2 (en) | 1979-05-11 | 1980-03-21 | Monacolin k |
NL8001697A NL8001697A (nl) | 1979-05-11 | 1980-03-21 | Werkwijze voor de bereiding van manocolin k. |
IT67445/80A IT1133075B (it) | 1979-05-11 | 1980-03-21 | Procedimento per la preparazione della monacolina k |
US06/137,821 US4323648A (en) | 1979-05-11 | 1980-04-04 | Preparation of Monacolin K |
KR1019800001707A KR830002329B1 (ko) | 1979-05-11 | 1980-04-29 | 모나콜린 k의 제조방법 |
SE8701483A SE468482B (sv) | 1979-05-11 | 1987-04-09 | Framstaellning av monakolin k |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5792779A JPS55150898A (en) | 1979-05-11 | 1979-05-11 | Preparation of a new physiologically active substance mb-530b |
KR1019800001707A KR830002329B1 (ko) | 1979-05-11 | 1980-04-29 | 모나콜린 k의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830002875A true KR830002875A (ko) | 1983-05-31 |
KR830002329B1 KR830002329B1 (ko) | 1983-10-22 |
Family
ID=26399012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800001707A KR830002329B1 (ko) | 1979-05-11 | 1980-04-29 | 모나콜린 k의 제조방법 |
Country Status (17)
Country | Link |
---|---|
US (1) | US4323648A (ko) |
JP (1) | JPS55150898A (ko) |
KR (1) | KR830002329B1 (ko) |
AT (1) | AT372975B (ko) |
AU (1) | AU534647B2 (ko) |
BE (1) | BE882325A (ko) |
CA (1) | CA1129795A (ko) |
CH (1) | CH645891A5 (ko) |
DE (2) | DE3006215A1 (ko) |
DK (1) | DK148807C (ko) |
ES (1) | ES489751A0 (ko) |
FR (1) | FR2456141A1 (ko) |
GB (1) | GB2049664B (ko) |
IE (1) | IE49749B1 (ko) |
IT (1) | IT1133075B (ko) |
NL (1) | NL8001697A (ko) |
SE (2) | SE467975B (ko) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
ES8105781A1 (es) * | 1979-07-27 | 1981-06-16 | Sankyo Co | Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos. |
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4351844A (en) * | 1980-02-04 | 1982-09-28 | Merck & Co., Inc. | Hypocholesterolemic hydrogenation products and process of preparation |
JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
US4343814A (en) * | 1980-11-17 | 1982-08-10 | Merck & Co., Inc. | Hypocholesterolemic fermentation products |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
JPS5855443A (ja) * | 1981-09-25 | 1983-04-01 | Sankyo Co Ltd | オクタヒドロナフタリン誘導体およびその製造法 |
US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
US4865977A (en) * | 1987-03-13 | 1989-09-12 | Shell Oil Company | Increasing monascus pigment production |
DE3801588A1 (de) * | 1988-01-21 | 1989-08-10 | Hoechst Ag | Verfahren zur herstellung von farbstoffen und/oder wirkstoffen in der wasserarmen, sterilen wirbelschicht |
KR960004032B1 (ko) * | 1992-10-26 | 1996-03-25 | 롯데제과주식회사 | 신균주 모나스커스 앵카 732y3(kccm10014) |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
BG61613B1 (bg) * | 1994-06-24 | 1998-01-30 | Анна Куюмджиева | Щам моnаsсus рurрurеus-продуцент на пигмент и биоактивни продукти |
US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
US6046022A (en) * | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
US6258361B1 (en) | 1996-10-21 | 2001-07-10 | Akio Yoshihara | Agent for recovering hematopoietic function and processed food both containing treated product of peanut seed coats |
US6391583B1 (en) | 1998-12-18 | 2002-05-21 | Wisconsin Alumni Research Foundation | Method of producing antihypercholesterolemic agents |
US20020197274A1 (en) * | 2001-04-19 | 2002-12-26 | Ming-Shi Shiao | Lithospermic acid-containing composition |
WO2003020218A2 (en) * | 2001-08-30 | 2003-03-13 | Taipei-Veterans General Hospital | Salvianolic acid b |
KR100379075B1 (en) * | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
TWI262949B (en) * | 2002-08-15 | 2006-10-01 | Food Industry Res & Dev Inst | Monascus purpureus mutants and their use in preparing fermentation products having hypotensive activity |
DE102004062386B4 (de) * | 2003-12-24 | 2010-06-24 | Food Industry Research And Development Institute | Monacolin K-Biosynthese-Gene |
KR100710500B1 (ko) * | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | 홍국균을 이용한 모나콜린 k 생산방법 |
US20120171285A1 (en) * | 2007-06-01 | 2012-07-05 | Opheim Joar A | Substances for reducing occurrence of major cardiac events comprising omega-3 polyunsaturated fatty acid or derivatives thereof and high-monacolin k content red yeast rice extract |
US20120172425A1 (en) * | 2007-06-01 | 2012-07-05 | Opheim Joar A | Red yeast rice extract high in monacolin k content |
US20100119600A1 (en) | 2007-06-01 | 2010-05-13 | Joar Opheim | Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof |
US20120171311A1 (en) * | 2007-06-01 | 2012-07-05 | Opheim Joar A | Substances for reducing occurrence of major cardiac events comprising epa or derivatives thereof, optionally, dha or derivatives thereof and monacolin k |
CN101317660B (zh) * | 2008-06-23 | 2012-10-24 | 谢键泓 | 一种提高红曲洛伐他汀在水中溶解度的方法及应用 |
CN102625705B (zh) * | 2009-04-08 | 2015-05-06 | 南洋理工学院 | 包含他汀类药物的植物提取物及其制备技术和用途 |
CN116083252B (zh) * | 2023-04-12 | 2023-06-27 | 北京一品堂医药科技有限公司 | 一种高产降脂天然莫拉可林k的红曲米发酵制备方法 |
CN116925926B (zh) * | 2023-07-14 | 2024-02-02 | 中国农业大学 | 富硒红色红曲霉发酵生产洛伐他汀的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (ko) * | 1974-06-07 | 1981-03-18 | ||
JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
-
1979
- 1979-05-11 JP JP5792779A patent/JPS55150898A/ja active Pending
-
1980
- 1980-02-20 DK DK73180A patent/DK148807C/da not_active IP Right Cessation
- 1980-02-20 DE DE19803006215 patent/DE3006215A1/de active Granted
- 1980-02-20 SE SE8001338A patent/SE467975B/sv not_active IP Right Cessation
- 1980-02-20 CH CH136780A patent/CH645891A5/de not_active IP Right Cessation
- 1980-02-20 DE DE3051097A patent/DE3051097C2/de not_active Expired - Lifetime
- 1980-03-04 GB GB8007240A patent/GB2049664B/en not_active Expired
- 1980-03-19 BE BE0/199871A patent/BE882325A/fr not_active IP Right Cessation
- 1980-03-19 AT AT0148280A patent/AT372975B/de not_active IP Right Cessation
- 1980-03-20 ES ES489751A patent/ES489751A0/es active Granted
- 1980-03-20 CA CA348,220A patent/CA1129795A/en not_active Expired
- 1980-03-20 FR FR8006203A patent/FR2456141A1/fr active Granted
- 1980-03-20 IE IE577/80A patent/IE49749B1/en not_active IP Right Cessation
- 1980-03-21 AU AU56678/80A patent/AU534647B2/en not_active Expired
- 1980-03-21 NL NL8001697A patent/NL8001697A/nl not_active Application Discontinuation
- 1980-03-21 IT IT67445/80A patent/IT1133075B/it active
- 1980-04-04 US US06/137,821 patent/US4323648A/en not_active Expired - Lifetime
- 1980-04-29 KR KR1019800001707A patent/KR830002329B1/ko active
-
1987
- 1987-04-09 SE SE8701483A patent/SE468482B/sv not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT1133075B (it) | 1986-07-09 |
DE3006215A1 (de) | 1980-11-27 |
IE800577L (en) | 1980-11-11 |
SE468482B (sv) | 1993-01-25 |
IT8067445A0 (it) | 1980-03-21 |
IE49749B1 (en) | 1985-12-11 |
FR2456141B1 (ko) | 1983-11-18 |
DE3051097C2 (ko) | 1990-02-08 |
FR2456141A1 (fr) | 1980-12-05 |
ES8104409A1 (es) | 1981-04-16 |
CH645891A5 (de) | 1984-10-31 |
DK148807B (da) | 1985-10-07 |
BE882325A (fr) | 1980-09-19 |
AT372975B (de) | 1983-12-12 |
NL8001697A (nl) | 1980-11-13 |
SE8701483D0 (sv) | 1987-04-09 |
AU534647B2 (en) | 1984-02-09 |
DE3006215C2 (ko) | 1989-01-05 |
CA1129795A (en) | 1982-08-17 |
SE8701483L (sv) | 1987-04-09 |
ATA148280A (de) | 1983-04-15 |
AU5667880A (en) | 1980-11-13 |
US4323648A (en) | 1982-04-06 |
ES489751A0 (es) | 1981-04-16 |
GB2049664B (en) | 1983-01-12 |
DK148807C (da) | 1986-04-28 |
GB2049664A (en) | 1980-12-31 |
DK73180A (da) | 1980-11-12 |
SE467975B (sv) | 1992-10-12 |
KR830002329B1 (ko) | 1983-10-22 |
SE8001338L (sv) | 1980-11-12 |
JPS55150898A (en) | 1980-11-25 |
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