KR940011638A - 6β, 14α-디히드록시-4-안드로스텐 3, 17-디온 제조방법 - Google Patents

6β, 14α-디히드록시-4-안드로스텐 3, 17-디온 제조방법 Download PDF

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KR940011638A
KR940011638A KR1019930024962A KR930024962A KR940011638A KR 940011638 A KR940011638 A KR 940011638A KR 1019930024962 A KR1019930024962 A KR 1019930024962A KR 930024962 A KR930024962 A KR 930024962A KR 940011638 A KR940011638 A KR 940011638A
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androsten
dione
dihydroxy
hydroxy
hydrolyzing
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KR1019930024962A
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히데끼 요시오까
하지메 아사다
신지 후지따
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다께다 가즈히꼬
닛뽕 가야꾸 가부시기가이샤
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Publication of KR940011638A publication Critical patent/KR940011638A/ko

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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/145—Fungal isolates
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

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Abstract

본 발명은 미로테슘속(Myrothecium 屬)에 속하며 4-안드로스텐-3, 17-디온을 가수 분해하여 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 생성할 수 있는 미생물을 4-안드로스텐-3,18-디온이 첨가된 배지에서 배양하여 배양지로부터 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 분리함을 특징으로 하는 6β,14α-디히드록시-4-안드로스텐-3,17-디온의 신규 제조 방법을 제공한다. 본 발명의 방법에 의하여 6β, 14α-디히드록시-4-안드로스텐-3,17-디온과 14α-히드록시-4-안드로스텐-3,6,17-트리온을 간단한 방법으로 고수율로 제조할 수 있다.

Description

6β, 14α-디히드록시-4-안드로스텐-3,17-디온 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. (가) 미로테슘속(Myrothecium 屬)에 속하며 4-안드로스텐-3, 17-디온을 가수 분해하여 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 생성할 수 있는 미생물을 4-안드로스텐-3,17-디온이 첨가된 배지에서 배양하고, (나) 배양된 배지로부터 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 분리함을 특징으로 하는 6β, 14α-디히드록시-4-안드로스텐-3,17-디온의 제조 방법.
  2. 미로테슘속에 속하며 4-안드로스텐-3,17-디온을 가수 분해하여 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 생성할 수 있는 미생물.
  3. 제2항에 의한 미생물로 4-안드로스텐-3,17-디온을 히드록실화하고 수득한 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 산화시켜 14α-히드록시-4-안드로스텐-3,6,17-트리온을 생성시키는 단계로 되어있고, 미로테슘 속에 속하며, 4-안드로스텐-3,17-디온을 가수 분해하여 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 생성할 수 있는 미생물을 4-안드로스텐-3,17-디온이 첨가된 배지에서 배양하여 수득한 6β, 14α-디히드록시-4-안드로스텐-3,17-디온을 배양 배지로부터 분리함을 특징으로 하는 14α-히드록시-4-안드로스텐-3,6,17-트리온의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930024962A 1992-11-27 1993-11-23 6β, 14α-디히드록시-4-안드로스텐 3, 17-디온 제조방법 KR940011638A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP92-339578 1992-11-27
JP33957892 1992-11-27
JP93-272912 1993-10-06
JP5272912A JPH06225793A (ja) 1992-11-27 1993-10-06 ６β，１４α−ジヒドロキシ−４−アンドロステン−３，１７−ジオンの新規製造法

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KR940011638A true KR940011638A (ko) 1994-06-21

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KR1019930024962A KR940011638A (ko) 1992-11-27 1993-11-23 6β, 14α-디히드록시-4-안드로스텐 3, 17-디온 제조방법

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US (1) US5378611A (ko)
EP (1) EP0599658A3 (ko)
JP (1) JPH06225793A (ko)
KR (1) KR940011638A (ko)
CN (1) CN1095418A (ko)
CA (1) CA2109680A1 (ko)
TW (1) TW256855B (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052585B2 (en) * 2008-10-24 2011-11-08 Stuart Donaldson Rehabilitation apparatus
ITMI20121788A1 (it) * 2012-10-22 2014-04-23 Olon Spa Procedimento per la purificazione di abiraterone acetato
CN106831919A (zh) * 2015-12-04 2017-06-13 上海市农药研究所有限公司 生物转化17α-羟基黄体酮生产11α,17α-双羟基黄体酮的提取工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382952A (en) * 1981-05-19 1983-05-10 Warner-Lambert Company Antibiotic roridin L-2 and its use
JPS63192796A (ja) * 1987-02-06 1988-08-10 Snow Brand Milk Prod Co Ltd ６β，１４α−ジヒドロキシ−４−アンドロステン−３，１７−ジオン
WO1988005781A1 (en) * 1987-02-06 1988-08-11 Snow Brand Milk Products Co., Ltd. Novel androst-4-ene-3,17-dione derivatives and process for their preparation
FR2629455B1 (fr) * 1988-03-29 1991-09-27 Rhone Poulenc Agrochimie Derives de 2-(3-pyridinyl)3-(phenoxy) propanenitrile
US5180827A (en) * 1988-03-29 1993-01-19 Rhone-Poulenc Agrochimie 2-(3-pyridyl) propanenitrile derivatives
JPH0643439B2 (ja) * 1989-02-07 1994-06-08 雪印乳業株式会社 光による６β，１４α‐ジヒドロキシ‐４‐アンドロステン‐３，１７‐ジオンの６β位水酸基の酸化方法
JP2844354B2 (ja) * 1989-08-03 1999-01-06 富士薬品工業株式会社 Ｄ―パントラクトンの製造法
DE4029389A1 (de) * 1990-09-13 1992-03-26 Schering Ag Verfahren zur herstellung von (beta)-carbolin-derivaten

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Publication number Publication date
CA2109680A1 (en) 1994-05-28
US5378611A (en) 1995-01-03
CN1095418A (zh) 1994-11-23
EP0599658A3 (en) 1995-07-12
EP0599658A2 (en) 1994-06-01
JPH06225793A (ja) 1994-08-16
TW256855B (ko) 1995-09-11

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