DK148807C - Fremgangsmaade til fremstilling af monacolin k - Google Patents

Fremgangsmaade til fremstilling af monacolin k

Info

Publication number
DK148807C
DK148807C DK73180A DK73180A DK148807C DK 148807 C DK148807 C DK 148807C DK 73180 A DK73180 A DK 73180A DK 73180 A DK73180 A DK 73180A DK 148807 C DK148807 C DK 148807C
Authority
DK
Denmark
Prior art keywords
monacolin
manufacturing
manufacturing monacolin
Prior art date
Application number
DK73180A
Other languages
English (en)
Other versions
DK148807B (da
DK73180A (da
Inventor
Kazuhiko Tanzawa
Seigo Iwado
Yoshio Tsujita
Masao Kuroda
Kouhei Furuya
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK73180A publication Critical patent/DK73180A/da
Publication of DK148807B publication Critical patent/DK148807B/da
Application granted granted Critical
Publication of DK148807C publication Critical patent/DK148807C/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A22BUTCHERING; MEAT TREATMENT; PROCESSING POULTRY OR FISH
    • A22CPROCESSING MEAT, POULTRY, OR FISH
    • A22C25/00Processing fish ; Curing of fish; Stunning of fish by electric current; Investigating fish by optical means
    • A22C25/16Removing fish-bones; Filleting fish
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/911Microorganisms using fungi
DK73180A 1979-05-11 1980-02-20 Fremgangsmaade til fremstilling af monacolin k DK148807C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5792779A JPS55150898A (en) 1979-05-11 1979-05-11 Preparation of a new physiologically active substance mb-530b
JP5792779 1979-05-11
KR1019800001707A KR830002329B1 (ko) 1979-05-11 1980-04-29 모나콜린 k의 제조방법
KR800001707 1980-04-29

Publications (3)

Publication Number Publication Date
DK73180A DK73180A (da) 1980-11-12
DK148807B DK148807B (da) 1985-10-07
DK148807C true DK148807C (da) 1986-04-28

Family

ID=26399012

Family Applications (1)

Application Number Title Priority Date Filing Date
DK73180A DK148807C (da) 1979-05-11 1980-02-20 Fremgangsmaade til fremstilling af monacolin k

Country Status (17)

Country Link
US (1) US4323648A (da)
JP (1) JPS55150898A (da)
KR (1) KR830002329B1 (da)
AT (1) AT372975B (da)
AU (1) AU534647B2 (da)
BE (1) BE882325A (da)
CA (1) CA1129795A (da)
CH (1) CH645891A5 (da)
DE (2) DE3006215A1 (da)
DK (1) DK148807C (da)
ES (1) ES489751A0 (da)
FR (1) FR2456141A1 (da)
GB (1) GB2049664B (da)
IE (1) IE49749B1 (da)
IT (1) IT1133075B (da)
NL (1) NL8001697A (da)
SE (2) SE467975B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンkおよびその製造法
ES8105781A1 (es) * 1979-07-27 1981-06-16 Sankyo Co Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos.
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4351844A (en) * 1980-02-04 1982-09-28 Merck & Co., Inc. Hypocholesterolemic hydrogenation products and process of preparation
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Mb−530b誘導体およびその製造法
JPS5855443A (ja) * 1981-09-25 1983-04-01 Sankyo Co Ltd オクタヒドロナフタリン誘導体およびその製造法
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds
US4865977A (en) * 1987-03-13 1989-09-12 Shell Oil Company Increasing monascus pigment production
DE3801588A1 (de) * 1988-01-21 1989-08-10 Hoechst Ag Verfahren zur herstellung von farbstoffen und/oder wirkstoffen in der wasserarmen, sterilen wirbelschicht
KR960004032B1 (ko) * 1992-10-26 1996-03-25 롯데제과주식회사 신균주 모나스커스 앵카 732y3(kccm10014)
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
BG61613B1 (bg) * 1994-06-24 1998-01-30 Анна Куюмджиева Щам моnаsсus рurрurеus-продуцент на пигмент и биоактивни продукти
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) * 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US6258361B1 (en) 1996-10-21 2001-07-10 Akio Yoshihara Agent for recovering hematopoietic function and processed food both containing treated product of peanut seed coats
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
US20020197274A1 (en) * 2001-04-19 2002-12-26 Ming-Shi Shiao Lithospermic acid-containing composition
WO2003020218A2 (en) * 2001-08-30 2003-03-13 Taipei-Veterans General Hospital Salvianolic acid b
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
TWI262949B (en) * 2002-08-15 2006-10-01 Food Industry Res & Dev Inst Monascus purpureus mutants and their use in preparing fermentation products having hypotensive activity
DE102004062386B4 (de) * 2003-12-24 2010-06-24 Food Industry Research And Development Institute Monacolin K-Biosynthese-Gene
KR100710500B1 (ko) * 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 k 생산방법
US20120171285A1 (en) * 2007-06-01 2012-07-05 Opheim Joar A Substances for reducing occurrence of major cardiac events comprising omega-3 polyunsaturated fatty acid or derivatives thereof and high-monacolin k content red yeast rice extract
US20120172425A1 (en) * 2007-06-01 2012-07-05 Opheim Joar A Red yeast rice extract high in monacolin k content
US20100119600A1 (en) 2007-06-01 2010-05-13 Joar Opheim Substances for reducing occurrence of major cardiac events comprising red yeast rice extract and omega-3 polyunsaturated fatty acid or derivative thereof
US20120171311A1 (en) * 2007-06-01 2012-07-05 Opheim Joar A Substances for reducing occurrence of major cardiac events comprising epa or derivatives thereof, optionally, dha or derivatives thereof and monacolin k
CN101317660B (zh) * 2008-06-23 2012-10-24 谢键泓 一种提高红曲洛伐他汀在水中溶解度的方法及应用
CN102625705B (zh) * 2009-04-08 2015-05-06 南洋理工学院 包含他汀类药物的植物提取物及其制备技术和用途
CN116083252B (zh) * 2023-04-12 2023-06-27 北京一品堂医药科技有限公司 一种高产降脂天然莫拉可林k的红曲米发酵制备方法
CN116925926B (zh) * 2023-07-14 2024-02-02 中国农业大学 富硒红色红曲霉发酵生产洛伐他汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (da) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンkおよびその製造法
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IT1133075B (it) 1986-07-09
DE3006215A1 (de) 1980-11-27
IE800577L (en) 1980-11-11
SE468482B (sv) 1993-01-25
IT8067445A0 (it) 1980-03-21
IE49749B1 (en) 1985-12-11
FR2456141B1 (da) 1983-11-18
DE3051097C2 (da) 1990-02-08
FR2456141A1 (fr) 1980-12-05
ES8104409A1 (es) 1981-04-16
CH645891A5 (de) 1984-10-31
DK148807B (da) 1985-10-07
BE882325A (fr) 1980-09-19
AT372975B (de) 1983-12-12
NL8001697A (nl) 1980-11-13
SE8701483D0 (sv) 1987-04-09
AU534647B2 (en) 1984-02-09
DE3006215C2 (da) 1989-01-05
CA1129795A (en) 1982-08-17
SE8701483L (sv) 1987-04-09
KR830002875A (ko) 1983-05-31
ATA148280A (de) 1983-04-15
AU5667880A (en) 1980-11-13
US4323648A (en) 1982-04-06
ES489751A0 (es) 1981-04-16
GB2049664B (en) 1983-01-12
GB2049664A (en) 1980-12-31
DK73180A (da) 1980-11-12
SE467975B (sv) 1992-10-12
KR830002329B1 (ko) 1983-10-22
SE8001338L (sv) 1980-11-12
JPS55150898A (en) 1980-11-25

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