KR20240074820A - Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물 - Google Patents

Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물 Download PDF

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KR20240074820A
KR20240074820A KR1020247013986A KR20247013986A KR20240074820A KR 20240074820 A KR20240074820 A KR 20240074820A KR 1020247013986 A KR1020247013986 A KR 1020247013986A KR 20247013986 A KR20247013986 A KR 20247013986A KR 20240074820 A KR20240074820 A KR 20240074820A
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methyl
compound
methoxy
pyrazol
acrylamide
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서병철
파레쉬 데비다스 살가온카
이재규
고종성
송호준
이인용
이재상
정동식
김정호
김세원
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주식회사유한양행
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
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  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quick-Acting Or Multi-Walled Pipe Joints (AREA)
KR1020247013986A 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물 Pending KR20240074820A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462063394P 2014-10-13 2014-10-13
US62/063,394 2014-10-13
PCT/KR2015/010784 WO2016060443A2 (en) 2014-10-13 2015-10-13 Compounds and compositions for modulating egfr mutant kinase activities
KR1020237000623A KR102662358B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물

Related Parent Applications (1)

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KR1020237000623A Division KR102662358B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물

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KR20240074820A true KR20240074820A (ko) 2024-05-28

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KR1020247013986A Pending KR20240074820A (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020237000623A Active KR102662358B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020177012969A Active KR102073854B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020207002949A Active KR102208775B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020217002019A Active KR102487451B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물

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Application Number Title Priority Date Filing Date
KR1020237000623A Active KR102662358B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020177012969A Active KR102073854B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020207002949A Active KR102208775B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물
KR1020217002019A Active KR102487451B1 (ko) 2014-10-13 2015-10-13 Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물

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US (2) US9593098B2 (enExample)
EP (4) EP3207035B1 (enExample)
JP (3) JP6524221B2 (enExample)
KR (5) KR20240074820A (enExample)
CN (2) CN111686110B (enExample)
AU (1) AU2015331166B2 (enExample)
BR (1) BR112017007769B1 (enExample)
CA (1) CA2962914C (enExample)
CY (2) CY1122737T1 (enExample)
DK (3) DK3207035T3 (enExample)
ES (3) ES2879474T3 (enExample)
FI (2) FI3929190T3 (enExample)
FR (1) FR25C1021I1 (enExample)
HR (3) HRP20250213T1 (enExample)
HU (4) HUE054848T2 (enExample)
LT (4) LT3207035T (enExample)
MX (3) MX2017003181A (enExample)
NL (1) NL301329I2 (enExample)
NO (1) NO2025025I1 (enExample)
NZ (1) NZ730012A (enExample)
PH (1) PH12017500488A1 (enExample)
PL (3) PL3604294T3 (enExample)
PT (3) PT3207035T (enExample)
RS (3) RS61865B1 (enExample)
RU (1) RU2727700C2 (enExample)
SG (1) SG11201701960XA (enExample)
SI (3) SI3207035T1 (enExample)
SM (3) SMT202100266T1 (enExample)
TW (2) TWI730331B (enExample)
WO (1) WO2016060443A2 (enExample)

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