KR20230134598A - 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법 - Google Patents

베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법 Download PDF

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KR20230134598A
KR20230134598A KR1020237029438A KR20237029438A KR20230134598A KR 20230134598 A KR20230134598 A KR 20230134598A KR 1020237029438 A KR1020237029438 A KR 1020237029438A KR 20237029438 A KR20237029438 A KR 20237029438A KR 20230134598 A KR20230134598 A KR 20230134598A
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acid
disease
berberine
liver
preferred embodiments
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KR1020237029438A
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Korean (ko)
Inventor
리핑 리우
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센젠 하이타이드 바이오파마슈티컬 리미티드
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Priority to KR1020247042512A priority Critical patent/KR20250008786A/ko
Publication of KR20230134598A publication Critical patent/KR20230134598A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
KR1020237029438A 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법 Ceased KR20230134598A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247042512A KR20250008786A (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462030140P 2014-07-29 2014-07-29
US201462030147P 2014-07-29 2014-07-29
US62/030,140 2014-07-29
US62/030,147 2014-07-29
US201562128077P 2015-03-04 2015-03-04
US62/128,077 2015-03-04
PCT/CN2015/085350 WO2016015634A1 (en) 2014-07-29 2015-07-28 Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
KR1020177004835A KR102573865B1 (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법

Related Parent Applications (1)

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KR1020177004835A Division KR102573865B1 (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법

Related Child Applications (1)

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KR1020247042512A Division KR20250008786A (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법

Publications (1)

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KR20230134598A true KR20230134598A (ko) 2023-09-21

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ID=55216773

Family Applications (3)

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KR1020237029438A Ceased KR20230134598A (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법
KR1020247042512A Pending KR20250008786A (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법
KR1020177004835A Active KR102573865B1 (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법

Family Applications After (2)

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KR1020247042512A Pending KR20250008786A (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법
KR1020177004835A Active KR102573865B1 (ko) 2014-07-29 2015-07-28 베르베린 염, 우르소데옥시콜산 염 및 병용물, 이들의 제조 및 응용 방법

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US (4) US10301303B2 (https=)
EP (1) EP3174874B1 (https=)
JP (4) JP6917144B2 (https=)
KR (3) KR20230134598A (https=)
CN (2) CN110179792A (https=)
AU (2) AU2015296098B2 (https=)
BR (1) BR112017001623B1 (https=)
CA (3) CA3290585A1 (https=)
DK (1) DK3174874T3 (https=)
EA (1) EA032971B1 (https=)
ES (1) ES2835874T3 (https=)
IL (3) IL282156B (https=)
MX (3) MX373840B (https=)
NZ (1) NZ728488A (https=)
SG (1) SG11201700481YA (https=)
WO (1) WO2016015634A1 (https=)

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US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
WO2015171598A1 (en) * 2014-05-05 2015-11-12 The Board Of Regents Of The University Of Texas System Methods and compositions comprising ursolic acid and/or resveratrol for treating obesity, diabetes, or cancer
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
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