KR20230109779A - Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 - Google Patents

Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 Download PDF

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KR20230109779A
KR20230109779A KR1020237023088A KR20237023088A KR20230109779A KR 20230109779 A KR20230109779 A KR 20230109779A KR 1020237023088 A KR1020237023088 A KR 1020237023088A KR 20237023088 A KR20237023088 A KR 20237023088A KR 20230109779 A KR20230109779 A KR 20230109779A
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tl1a
subject
composition
disease
fibrosis
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Korean (ko)
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데이비드 큐. 시
스티븐 알. 타간
달린 리
자닌 빌스보러
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세다르스-신나이 메디칼 센터
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Application filed by 세다르스-신나이 메디칼 센터 filed Critical 세다르스-신나이 메디칼 센터
Priority to KR1020247025680A priority Critical patent/KR20240122922A/ko
Publication of KR20230109779A publication Critical patent/KR20230109779A/ko
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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KR1020237023088A 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 Ceased KR20230109779A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247025680A KR20240122922A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361805806P 2013-03-27 2013-03-27
US61/805,806 2013-03-27
US201361872020P 2013-08-30 2013-08-30
US61/872,020 2013-08-30
KR1020217041432A KR20210157418A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
PCT/US2014/032054 WO2014160883A1 (en) 2013-03-27 2014-03-27 Treating fibrosis and inflammation by inhibiting tl1a

Related Parent Applications (1)

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KR1020217041432A Division KR20210157418A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전

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KR1020247025680A Division KR20240122922A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전

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KR20230109779A true KR20230109779A (ko) 2023-07-20

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ID=51625529

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020237023088A Ceased KR20230109779A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전
KR1020217041432A Ceased KR20210157418A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
KR1020247025680A Pending KR20240122922A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
KR1020157030431A Active KR102343212B1 (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020217041432A Ceased KR20210157418A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
KR1020247025680A Pending KR20240122922A (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
KR1020157030431A Active KR102343212B1 (ko) 2013-03-27 2014-03-27 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전

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Country Link
US (3) US10633449B2 (enExample)
EP (3) EP3639841B1 (enExample)
JP (4) JP6671276B2 (enExample)
KR (4) KR20230109779A (enExample)
CN (2) CN105246501B (enExample)
AU (1) AU2014241162A1 (enExample)
BR (1) BR112015024752A2 (enExample)
CA (1) CA2908553A1 (enExample)
CL (1) CL2015002866A1 (enExample)
MX (1) MX2015013703A (enExample)
WO (1) WO2014160883A1 (enExample)

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US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
BR112014007426B1 (pt) 2011-09-30 2023-01-03 Teva Pharmaceuticals Australia Pty Ltd Anticorpos contra tl1a e seus usos
AU2014241162A1 (en) 2013-03-27 2015-10-22 Cedars-Sinai Medical Center Mitigation and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
CN104745587B (zh) * 2015-01-05 2017-07-21 西安交通大学医学院第一附属医院 用于识别结缔组织生长因子的核酸适配子及其应用
JP2018522533A (ja) * 2015-05-15 2018-08-16 シーダーズ—シナイ メディカル センター 炎症性腸疾患を処置するためのモデル、方法および組成物
TWI703158B (zh) 2015-09-18 2020-09-01 美商希佛隆公司 特異性結合tl1a之抗體
CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
CN109476698B (zh) 2016-05-20 2023-10-17 西达-赛奈医疗中心 基于基因的炎性肠病诊断
WO2018156180A1 (en) 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
KR20220088529A (ko) 2019-05-14 2022-06-27 프로메테우스 바이오사이언시즈, 인크. Tl1a 환자 선택 방법, 시스템 및 장치
WO2021202926A1 (en) * 2020-04-02 2021-10-07 La Jolla Institute For Immunology Methods and combinations for dual targeting of tnf family members
WO2021247770A1 (en) * 2020-06-03 2021-12-09 Cedars-Sinai Medical Center Methods and systems for measuring post-operative disease recurrence
WO2024173877A1 (en) * 2023-02-17 2024-08-22 Prometheus Biosciences, Inc. Anti-tl1a antibody compositions and methods of treatment in the liver
WO2025038473A1 (en) 2023-08-11 2025-02-20 Paragon Therapeutics, Inc. Tl1a binding antibodies and methods of use

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