KR20230074703A - 유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법 - Google Patents

유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법 Download PDF

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KR20230074703A
KR20230074703A KR1020237002618A KR20237002618A KR20230074703A KR 20230074703 A KR20230074703 A KR 20230074703A KR 1020237002618 A KR1020237002618 A KR 1020237002618A KR 20237002618 A KR20237002618 A KR 20237002618A KR 20230074703 A KR20230074703 A KR 20230074703A
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viral vector
ser
leu
transgene
protein
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에이만 이스마일
통야오 리우
무케쉬 마야니
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바이오버라티브 테라퓨틱스 인크.
폰다지오네 텔레톤
오스페달레 산 라파엘 에스.알.엘.
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    • B01D15/08—Selective adsorption, e.g. chromatography
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237002618A 2020-06-24 2021-06-24 유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법 Pending KR20230074703A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063043697P 2020-06-24 2020-06-24
US63/043,697 2020-06-24
US202063062120P 2020-08-06 2020-08-06
US63/062,120 2020-08-06
PCT/US2021/038871 WO2021262963A1 (en) 2020-06-24 2021-06-24 Methods for the removal of free factor viii from preparations of lentiviral vectors modified to express said protein

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Publication Number Publication Date
KR20230074703A true KR20230074703A (ko) 2023-05-31

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KR1020237002618A Pending KR20230074703A (ko) 2020-06-24 2021-06-24 유리 인자 viii을 상기 단백질이 발현되도록 변형된 렌티바이러스 벡터의 제제로부터 제거하는 방법

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US (2) US12173307B2 (https=)
EP (1) EP4171657A1 (https=)
JP (1) JP2023537565A (https=)
KR (1) KR20230074703A (https=)
CN (1) CN116033927A (https=)
AU (1) AU2021297965A1 (https=)
BR (1) BR112022026127A2 (https=)
CA (1) CA3183557A1 (https=)
IL (1) IL299333A (https=)
MX (1) MX2023000156A (https=)
TW (1) TW202208619A (https=)
WO (1) WO2021262963A1 (https=)

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KR20220097891A (ko) 2019-09-30 2022-07-08 바이오버라티브 테라퓨틱스 인크. 렌티바이러스 벡터 제형
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CN119256087A (zh) * 2022-03-14 2025-01-03 布拉默生物有限责任公司 慢病毒制造平台
US20230331773A1 (en) * 2022-04-15 2023-10-19 Pall Corporation Chromatography device and method of use
CN115505578A (zh) * 2022-09-20 2022-12-23 苏州博腾生物制药有限公司 可放大的用于纯化重组病毒的方法
WO2025106701A1 (en) * 2023-11-15 2025-05-22 Tectaria Bio Llc Compositions and methods for increased protein production

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