KR20210113202A - 배위자, 스페이서, 펩티드 링커 및 생물 분자를 포함하는 복합체 - Google Patents

배위자, 스페이서, 펩티드 링커 및 생물 분자를 포함하는 복합체 Download PDF

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KR20210113202A
KR20210113202A KR1020217020761A KR20217020761A KR20210113202A KR 20210113202 A KR20210113202 A KR 20210113202A KR 1020217020761 A KR1020217020761 A KR 1020217020761A KR 20217020761 A KR20217020761 A KR 20217020761A KR 20210113202 A KR20210113202 A KR 20210113202A
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seq
amino acid
complex
cancer
acid sequence
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미치노리 아카이와
준야 이시다
히로키 도야
도루 아사노
도모아키 요시카와
요리카타 사노
유키히토 스가노
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아스텔라스세이야쿠 가부시키가이샤
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI780082B (zh) 2016-11-18 2022-10-11 日商安斯泰來製藥股份有限公司 新穎抗人類ＭＵＣ１抗體Ｆａｂ片段
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
MX2020012351A (es) * 2018-05-17 2021-01-29 Astellas Pharma Inc Complejo que tiene fragmento fab de anticuerpo anti-muc1 de humano, enlazador peptido y/o ligando.
CA3115747A1 (en) 2018-10-10 2020-04-16 Astellas Pharma Inc. Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
CA3174082A1 (en) 2020-03-04 2021-09-10 Nihon Medi-Physics Co., Ltd. Compound and radioactive labeling compound
KR20230154183A (ko) 2021-03-04 2023-11-07 니혼 메디피직스 가부시키가이샤 화합물 및 방사성 표지 화합물
CN118852044A (zh) * 2021-09-03 2024-10-29 晶核生物医药科技(南京)有限公司 一种肽脲素衍生物、含其的药物组合物及其应用
EP4536278A2 (en) * 2022-06-07 2025-04-16 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
CA3265394A1 (en) * 2022-08-22 2024-02-29 Abdera Therapeutics Inc. VHH ANTIBODY CONJUGATES
WO2024235134A1 (zh) * 2023-05-12 2024-11-21 四川科伦博泰生物医药股份有限公司 具有靶向作用的偶联物及其制备方法和用途
WO2024243315A2 (en) * 2023-05-22 2024-11-28 Actinium Pharmaceuticals, Inc. Multi-arm bifunctional chelators
WO2025232116A1 (zh) * 2024-05-10 2025-11-13 四川科伦博泰生物医药股份有限公司 具有靶向作用的偶联物及其制备方法和用途
US12600794B2 (en) 2024-07-23 2026-04-14 Abdera Therapeutics Inc. 5T4 binding polypeptides and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005086875A2 (en) 2004-03-11 2005-09-22 City Of Hope A humanized anti-cea t84.66 antibody and uses thereof
WO2008040362A2 (en) 2006-10-04 2008-04-10 Københavns Universitet Generation of a cancer-specific immune response toward muc1 and cancer specific muc1 antibodies
WO2010050528A1 (ja) 2008-10-28 2010-05-06 塩野義製薬株式会社 抗ｍｕｃ１抗体
WO2013081091A1 (ja) 2011-12-01 2013-06-06 国立大学法人 千葉大学 非特異的腎集積が低減された放射性標識ポリペプチド作製用薬剤
WO2017150549A1 (ja) 2016-03-01 2017-09-08 国立大学法人 千葉大学 放射性標識薬剤
WO2018092885A1 (ja) 2016-11-18 2018-05-24 アステラス製薬株式会社 新規な抗ヒトＭＵＣ１抗体Ｆａｂフラグメント
WO2019065774A1 (ja) 2017-09-26 2019-04-04 国立大学法人 千葉大学 放射性薬剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
CA2803520C (en) * 2009-07-08 2019-10-22 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
CN102666567B (zh) * 2009-12-04 2015-08-26 免疫医疗公司 用于蛋白质、肽和其它分子的改进的f-18标记的方法和组合物
EP2471557A1 (en) * 2010-12-27 2012-07-04 Università degli Studi di Genova A conjugate of human albumin and 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid useful for the localization of radionuclides for diagnostic and therapeutic purposes
KR102056932B1 (ko) * 2011-10-10 2019-12-17 시티 오브 호프 메디토프와 메디토프-결합 항체 및 이들의 용도
MX379256B (es) * 2013-03-15 2025-03-10 Regeneron Pharma Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
CN117138060A (zh) * 2014-10-07 2023-12-01 免疫医疗公司 抗体-药物缀合物的新辅助剂用途
CA2968990A1 (en) * 2015-01-09 2016-07-14 Immunomedics, Inc. Radiosensitivity of fluorophores and use of radioprotective agents for dual-modality imaging
US10758632B2 (en) * 2017-02-06 2020-09-01 City Of Hope NIR-conjugated tumor-specific antibodies and uses thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005086875A2 (en) 2004-03-11 2005-09-22 City Of Hope A humanized anti-cea t84.66 antibody and uses thereof
WO2008040362A2 (en) 2006-10-04 2008-04-10 Københavns Universitet Generation of a cancer-specific immune response toward muc1 and cancer specific muc1 antibodies
WO2010050528A1 (ja) 2008-10-28 2010-05-06 塩野義製薬株式会社 抗ｍｕｃ１抗体
WO2013081091A1 (ja) 2011-12-01 2013-06-06 国立大学法人 千葉大学 非特異的腎集積が低減された放射性標識ポリペプチド作製用薬剤
WO2017150549A1 (ja) 2016-03-01 2017-09-08 国立大学法人 千葉大学 放射性標識薬剤
WO2018092885A1 (ja) 2016-11-18 2018-05-24 アステラス製薬株式会社 新規な抗ヒトＭＵＣ１抗体Ｆａｂフラグメント
WO2019065774A1 (ja) 2017-09-26 2019-04-04 国立大学法人 千葉大学 放射性薬剤

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
Ann.Surg.; 1997; 226: 621-631
Bioconjug.Chem.; 2008; 19: 89-96
Bioconjugate Chem. 1997, 8, 365-369
Bioconjugate Chem. 2001, 12, 264-270
Bioconjugate Chem. 2002, 13, 985-995
Bioconjugate Chem. 2007, 18, 190-198
Bioconjugate Chem. 2013, 24, 291-299
Bioconjugate Chem. 2014, 25, 2038-2045
Bioorg. Med. Chem.; 2019; 27: 3248-3253
Cancer Immunol Immunother, 2006 Nov; 55(11): 1337-47
Cancer Res. 1999, 59, 128-134
Clinical Trials.gov Identifier: NCT02592707
Eur J Haematol. 2013 Dec; 91(6): 552-6
Glycoconj. J., 2013 Apr; 30(3): 227-36.
J.Nucl.Med.; 2000; 41: 1657-1663
Kenneth T.Cheng, "99mTc-Arcitumomab", [online], Update: March 17, 2008., Molecular Imaging and Contrast Agent Database, [2017년 5월 17일 검색], 인터넷 <URL: https://www.ncbi.nlm.nih.gov/books/NBK23676/>
PLOS ONE; 2014; 9(9): e106921

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