SG11202107400QA - Conjugate comprising ligand and ceacam5 antibody fab fragment - Google Patents

Conjugate comprising ligand and ceacam5 antibody fab fragment

Info

Publication number
SG11202107400QA
SG11202107400QA SG11202107400QA SG11202107400QA SG11202107400QA SG 11202107400Q A SG11202107400Q A SG 11202107400QA SG 11202107400Q A SG11202107400Q A SG 11202107400QA SG 11202107400Q A SG11202107400Q A SG 11202107400QA SG 11202107400Q A SG11202107400Q A SG 11202107400QA
Authority
SG
Singapore
Prior art keywords
conjugate
ligand
fab fragment
antibody fab
ceacam5 antibody
Prior art date
Application number
SG11202107400QA
Inventor
Michinori Akaiwa
Junya Ishida
Hiroki Toya
Nobuyuki Shiraishi
Toru Asano
Tomoaki Yoshikawa
Yorikata Sano
Hitoshi Doihara
Hiroki Shirai
Kazunori Hirayama
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of SG11202107400QA publication Critical patent/SG11202107400QA/en

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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CA3043816A1 (en) 2016-11-18 2018-05-24 Astellas Pharma Inc. Novel anti-human muc1 antibody fab fragment
TWI795415B (en) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 A novel anti-human CEACAM5 antibody Fab fragment
WO2019221269A1 (en) * 2018-05-17 2019-11-21 アステラス製薬株式会社 COMPLEX HAVING ANTI-HUMAN MUC1 ANTIBODY Fab FRAGMENT, PEPTIDE LINKER AND/OR LIGAND
TWI835880B (en) 2018-10-10 2024-03-21 日商安斯泰來製藥股份有限公司 Pharmaceutical composition containing labeling part-anti-human antibody Fab fragment complex
AU2021230210A1 (en) 2020-03-04 2022-09-22 Kyoto University Compound and radioactive labeling compound
US20240174622A1 (en) 2021-03-04 2024-05-30 Nihon Medi-Physics Co., Ltd. Compound and radioactive labeling compound
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
TW202421115A (en) * 2022-08-22 2024-06-01 美商雅博得樂醫療公司 Vhh antibody conjugates

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WO2008040362A2 (en) 2006-10-04 2008-04-10 Københavns Universitet Generation of a cancer-specific immune response toward muc1 and cancer specific muc1 antibodies
WO2010050528A1 (en) 2008-10-28 2010-05-06 塩野義製薬株式会社 Anti-muc1 antibody
US8877157B2 (en) * 2009-07-08 2014-11-04 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
JP5789821B2 (en) * 2009-12-04 2015-10-07 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
IL296507A (en) * 2011-10-10 2022-11-01 Hope City Meditopes and meditope-binding antibodies and uses thereof
WO2013081091A1 (en) 2011-12-01 2013-06-06 国立大学法人 千葉大学 Drug for producing radiolabeled polypeptide reducing non-specific renal accumulation
EP3204018B1 (en) * 2014-10-07 2021-08-25 Immunomedics, Inc. Neoadjuvant use of antibody-drug conjugates
EP3242691A1 (en) * 2015-01-09 2017-11-15 Immunomedics, Inc. Radiosensitivity of fluorophores and use of radioprotective agents for dual-modality imaging
CN108699108B (en) 2016-03-01 2022-04-08 国立大学法人千叶大学 Radiolabeled pharmaceutical
CA3043816A1 (en) 2016-11-18 2018-05-24 Astellas Pharma Inc. Novel anti-human muc1 antibody fab fragment
US10758632B2 (en) * 2017-02-06 2020-09-01 City Of Hope NIR-conjugated tumor-specific antibodies and uses thereof
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