CO2021010116A2 - Conjugado que comprende ligando y fragmento fab de anticuerpo ceacam5 - Google Patents

Conjugado que comprende ligando y fragmento fab de anticuerpo ceacam5

Info

Publication number
CO2021010116A2
CO2021010116A2 CONC2021/0010116A CO2021010116A CO2021010116A2 CO 2021010116 A2 CO2021010116 A2 CO 2021010116A2 CO 2021010116 A CO2021010116 A CO 2021010116A CO 2021010116 A2 CO2021010116 A2 CO 2021010116A2
Authority
CO
Colombia
Prior art keywords
conjugate
ligand
fab fragment
ceacam5 antibody
fragment
Prior art date
Application number
CONC2021/0010116A
Other languages
English (en)
Inventor
Hiroki Shirai
Kazunori Hirayama
Hitoshi Doihara
Michinori Akaiwa
Hiroki Toya
Junya Ishida
Toru Asano
Tomoaki Yoshikawa
Yorikata Sano
Nobuyuki Shiraishi
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CO2021010116A2 publication Critical patent/CO2021010116A2/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

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Abstract

RESUMEN Se proporciona un conjugado que comprende un ligando, un espaciador y un péptido enlazador útil para un fármaco de diagnóstico in vivo y radioterapia interna, utilizando un fragmento Fab de anticuerpo anti-CEACAM5 humano cuya actividad de unión no se atenúa ni siquiera mediante el etiquetado con un metal, un tinte fluorescente o similar. Un conjugado que comprende un fragmento Fab de anticuerpo anti-CEACAM5 humano y un ligando, el fragmento que comprende un fragmento de cadena pesada que incluye una región variable de cadena pesada que consiste en una secuencia de aminoácidos específica y una cadena ligera que incluye una región variable de cadena ligera que consiste en una secuencia de aminoácidos específica, o un conjugado que comprende un ligando, un espaciador y un péptido enlazador, en donde la actividad de unión de los mismos no se atenúa incluso etiquetado con un metal, un colorante fluorescente o similar, puede usarse como una composición de diagnóstico y/o una composición farmacéutica.
CONC2021/0010116A 2019-01-07 2021-07-30 Conjugado que comprende ligando y fragmento fab de anticuerpo ceacam5 CO2021010116A2 (es)

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PCT/JP2020/000037 WO2020145228A1 (ja) 2019-01-07 2020-01-06 配位子及びＣＥＡＣＡＭ５抗体Ｆａｂフラグメントからなる複合体

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TWI835880B (zh) 2018-10-10 2024-03-21 日商安斯泰來製藥股份有限公司 含有標識部－抗人類抗體Ｆａｂ片段複合體之醫藥組成物
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