JOP20210183A1 - مادة اقتران تشتمل على ربيطة وشدفة Fab لجسم مضاد لـ CEACAM5 - Google Patents

مادة اقتران تشتمل على ربيطة وشدفة Fab لجسم مضاد لـ CEACAM5

Info

Publication number
JOP20210183A1
JOP20210183A1 JOP/2021/0183A JOP20210183A JOP20210183A1 JO P20210183 A1 JOP20210183 A1 JO P20210183A1 JO P20210183 A JOP20210183 A JO P20210183A JO P20210183 A1 JOP20210183 A1 JO P20210183A1
Authority
JO
Jordan
Prior art keywords
conjugate
ligand
antibody fab
fab fragment
ceacam5 antibody
Prior art date
Application number
JOP/2021/0183A
Other languages
English (en)
Inventor
Toya Hiroki
Asano Toru
Yoshikawa Tomoaki
Ishida Junya
Akaiwa Michinori
Sano Yorikata
Hirayama Kazunori
Shiraishi Nobuyuki
Doihara Hitoshi
Shirai Hiroki
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of JOP20210183A1 publication Critical patent/JOP20210183A1/ar

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Abstract

يزود هذا الاختراع مادة اقتران تشتمل على ربيطة، فاصل ورابط ببتيدي مفيدة للاستخدام في عقار تشخيصي في الجسم الحي وعلاج إشعاعي داخلي، باستخدام شدفة Fab لجسم مضاد ضد CEACAM5 بشري حيث لا يتم تخفيف نشاط الارتباط الخاص بها حتى لو تم الوسم بفلز، صبغة فلورية، وما أشبه. ويزود هذا الاختراع مادة اقتران تشتمل على شدفة Fab لجسم مضاد ضد CEACAM5 بشري وربيطة، وتشتمل الشدفة على شدفة لسلسلة ثقيلة تتضمن منطقة متغيرة لسلسلة ثقيلة تتكون من سياق أحماض أمينية محدد وسلسلة خفيفة تتضمن منطقة متغيرة لسلسلة خفيفة تتكون من سياق أحماض أمينية محدد، أو مادة اقتران تشتمل على ربيطة، فاصل ورابط ببتيدي، حيث لا يتم تخفيف نشاط الارتباط الخاص بها حتى لو تم الوسم بفلز، صبغة فلورية، وما أشبه كتركيبة تشخيصية و/أو تركيبة صيدلانية.
JOP/2021/0183A 2019-01-07 2020-01-06 مادة اقتران تشتمل على ربيطة وشدفة Fab لجسم مضاد لـ CEACAM5 JOP20210183A1 (ar)

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