MX2022013163A - Anticuerpo contra nectin-4 y aplicacion del mismo. - Google Patents

Anticuerpo contra nectin-4 y aplicacion del mismo.

Info

Publication number
MX2022013163A
MX2022013163A MX2022013163A MX2022013163A MX2022013163A MX 2022013163 A MX2022013163 A MX 2022013163A MX 2022013163 A MX2022013163 A MX 2022013163A MX 2022013163 A MX2022013163 A MX 2022013163A MX 2022013163 A MX2022013163 A MX 2022013163A
Authority
MX
Mexico
Prior art keywords
application
antibody against
nectin
against nectin
antibody
Prior art date
Application number
MX2022013163A
Other languages
English (en)
Inventor
Jin Wang
Jian Lin
Lichun Wang
Jian Wu
Hongyuan Ren
Jian Zhu
Xiaohong Xu
Xiaofang Deng
Jianjun Bi
Original Assignee
Mabwell Shanghai Bioscience Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mabwell Shanghai Bioscience Co Ltd filed Critical Mabwell Shanghai Bioscience Co Ltd
Publication of MX2022013163A publication Critical patent/MX2022013163A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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Abstract

Se proporciona una molécula de anticuerpo que se une a la Nectin-4 humana o a un fragmento de la misma. El anticuerpo se obtiene por medio de técnicas de humanización y cribado de hibridomas, y se utiliza para la prevención o el tratamiento de un cáncer, y puede utilizarse como molécula de fármaco líder clínico.
MX2022013163A 2020-04-21 2021-04-21 Anticuerpo contra nectin-4 y aplicacion del mismo. MX2022013163A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010320420.3A CN113527486A (zh) 2020-04-21 2020-04-21 一种抗Nectin-4的抗体及其应用
PCT/CN2021/088661 WO2021213434A1 (zh) 2020-04-21 2021-04-21 一种抗Nectin-4的抗体及其应用

Publications (1)

Publication Number Publication Date
MX2022013163A true MX2022013163A (es) 2022-11-30

Family

ID=78094041

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013163A MX2022013163A (es) 2020-04-21 2021-04-21 Anticuerpo contra nectin-4 y aplicacion del mismo.

Country Status (10)

Country Link
US (1) US20230265183A1 (es)
EP (1) EP4141029A1 (es)
JP (1) JP2023522229A (es)
KR (1) KR20230007406A (es)
CN (2) CN113527486A (es)
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CA3230122A1 (en) * 2021-08-27 2023-03-02 Zhaopeng SUN Anti-nectin-4 antibody, drug conjugate and preparation method therefor_and use thereof
CN116063498A (zh) * 2022-04-27 2023-05-05 博际生物医药科技(杭州)有限公司 单域抗Nectin-4抗体
CN114702588B (zh) * 2022-04-27 2022-11-22 博际生物医药科技(杭州)有限公司 抗Nectin-4抗体和双特异性抗体
CN114702589B (zh) * 2022-04-27 2022-11-01 博际生物医药科技(杭州)有限公司 治疗癌症的组合物和方法
WO2023221971A1 (zh) * 2022-05-16 2023-11-23 江苏恒瑞医药股份有限公司 一种含抗Nectin-4抗体药物偶联物的药物组合物及其用途
WO2024012539A1 (zh) * 2022-07-14 2024-01-18 百奥泰生物制药股份有限公司 抗Nectin-4抗体及其应用
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WO2024062476A1 (en) * 2022-09-20 2024-03-28 Nectin Therapeutics Ltd. Humanized antibodies against nectin-4 and drug conjugates thereof
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CN110392697A (zh) * 2017-03-02 2019-10-29 国家医疗保健研究所 对nectin-4具有特异性的抗体及其用途
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