CN115427452A - 一种抗Nectin-4的抗体及其应用 - Google Patents
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Abstract
提供一种结合人Nectin‑4的抗体分子或其片段,该抗体通过杂交瘤筛选和人源化技术获得,用于预防或治疗癌症,可作为临床先导药物分子。
Description
PCT国内申请,说明书已公开。
Claims (18)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN2020103204203 | 2020-04-21 | ||
CN202010320420.3A CN113527486A (zh) | 2020-04-21 | 2020-04-21 | 一种抗Nectin-4的抗体及其应用 |
PCT/CN2021/088661 WO2021213434A1 (zh) | 2020-04-21 | 2021-04-21 | 一种抗Nectin-4的抗体及其应用 |
Publications (1)
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CN115427452A true CN115427452A (zh) | 2022-12-02 |
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CN202010320420.3A Pending CN113527486A (zh) | 2020-04-21 | 2020-04-21 | 一种抗Nectin-4的抗体及其应用 |
CN202180030277.7A Pending CN115427452A (zh) | 2020-04-21 | 2021-04-21 | 一种抗Nectin-4的抗体及其应用 |
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CN202010320420.3A Pending CN113527486A (zh) | 2020-04-21 | 2020-04-21 | 一种抗Nectin-4的抗体及其应用 |
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Country | Link |
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US (1) | US20230265183A1 (zh) |
EP (1) | EP4141029A1 (zh) |
JP (1) | JP2023522229A (zh) |
KR (1) | KR20230007406A (zh) |
CN (2) | CN113527486A (zh) |
AU (1) | AU2021260639A1 (zh) |
BR (1) | BR112022021322A2 (zh) |
CA (1) | CA3176385A1 (zh) |
MX (1) | MX2022013163A (zh) |
WO (1) | WO2021213434A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117986367A (zh) * | 2024-04-02 | 2024-05-07 | 上海美迪西生物医药股份有限公司 | 靶点为Nectin-4的抗体及其应用 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230112656A (ko) * | 2020-11-25 | 2023-07-27 | 이나뜨 파르마 에스.에이. | 암의 치료 |
BR112023022549A2 (pt) * | 2021-04-30 | 2024-01-02 | Jiangsu Mabwell Health Pharmaceutical R&D Co Ltd | Conjugado anticorpo-fármaco direcionado à nectina-4 e método de preparação para o mesmo e uso do mesmo |
CN117897407A (zh) * | 2021-08-27 | 2024-04-16 | 石药集团巨石生物制药有限公司 | 抗Nectin-4抗体、药物缀合物及其制备方法和用途 |
CN114702589B (zh) * | 2022-04-27 | 2022-11-01 | 博际生物医药科技(杭州)有限公司 | 治疗癌症的组合物和方法 |
CN116063498A (zh) * | 2022-04-27 | 2023-05-05 | 博际生物医药科技(杭州)有限公司 | 单域抗Nectin-4抗体 |
CN114702588B (zh) * | 2022-04-27 | 2022-11-22 | 博际生物医药科技(杭州)有限公司 | 抗Nectin-4抗体和双特异性抗体 |
WO2023221971A1 (zh) * | 2022-05-16 | 2023-11-23 | 江苏恒瑞医药股份有限公司 | 一种含抗Nectin-4抗体药物偶联物的药物组合物及其用途 |
CN117402243A (zh) * | 2022-07-14 | 2024-01-16 | 百奥泰生物制药股份有限公司 | 抗Nectin-4抗体及其应用 |
EP4324849A1 (en) * | 2022-08-18 | 2024-02-21 | Emergence Therapeutics AG | Humanized anti-nectin-4 antibodies |
WO2024062476A1 (en) * | 2022-09-20 | 2024-03-28 | Nectin Therapeutics Ltd. | Humanized antibodies against nectin-4 and drug conjugates thereof |
CN117942409A (zh) * | 2022-10-28 | 2024-04-30 | 江苏迈威康新药研发有限公司 | 一种包含抗Nectin-4抗体药物偶联物的制剂及其应用 |
CN115877008A (zh) * | 2022-12-05 | 2023-03-31 | 中国科学院自动化研究所 | 用于膀胱癌检测的光学分子成像探针及其制备方法和应用 |
CN116381251A (zh) * | 2023-03-13 | 2023-07-04 | 广州鹏翔生物技术有限公司 | 一种肿瘤标志物诊断试剂盒及其诊断方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005111076A1 (en) * | 2004-05-12 | 2005-11-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Nectin 4 (n4) as a marker for cancer prognosis |
EP3347048B1 (en) * | 2015-09-09 | 2020-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies having specificity to nectin-4 and uses thereof |
CN109810039B (zh) * | 2017-11-22 | 2021-11-12 | 迈威(上海)生物科技股份有限公司 | 一种用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途 |
CN110392697A (zh) * | 2017-03-02 | 2019-10-29 | 国家医疗保健研究所 | 对nectin-4具有特异性的抗体及其用途 |
KR20200024788A (ko) * | 2017-06-05 | 2020-03-09 | 어젠시스 인코포레이티드 | 넥틴-4 결합 단백질 및 이의 사용 방법 |
-
2020
- 2020-04-21 CN CN202010320420.3A patent/CN113527486A/zh active Pending
-
2021
- 2021-04-21 CN CN202180030277.7A patent/CN115427452A/zh active Pending
- 2021-04-21 AU AU2021260639A patent/AU2021260639A1/en active Pending
- 2021-04-21 EP EP21791797.0A patent/EP4141029A1/en active Pending
- 2021-04-21 KR KR1020227040582A patent/KR20230007406A/ko active Search and Examination
- 2021-04-21 CA CA3176385A patent/CA3176385A1/en active Pending
- 2021-04-21 MX MX2022013163A patent/MX2022013163A/es unknown
- 2021-04-21 US US17/996,403 patent/US20230265183A1/en active Pending
- 2021-04-21 JP JP2022563917A patent/JP2023522229A/ja active Pending
- 2021-04-21 BR BR112022021322A patent/BR112022021322A2/pt unknown
- 2021-04-21 WO PCT/CN2021/088661 patent/WO2021213434A1/zh unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117986367A (zh) * | 2024-04-02 | 2024-05-07 | 上海美迪西生物医药股份有限公司 | 靶点为Nectin-4的抗体及其应用 |
Also Published As
Publication number | Publication date |
---|---|
EP4141029A1 (en) | 2023-03-01 |
CN113527486A (zh) | 2021-10-22 |
CA3176385A1 (en) | 2021-10-28 |
AU2021260639A1 (en) | 2022-12-08 |
WO2021213434A1 (zh) | 2021-10-28 |
BR112022021322A2 (pt) | 2022-12-06 |
MX2022013163A (es) | 2022-11-30 |
US20230265183A1 (en) | 2023-08-24 |
KR20230007406A (ko) | 2023-01-12 |
JP2023522229A (ja) | 2023-05-29 |
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