MX2021008229A - Conjugado que comprende ligando, espaciador, enlazador peptido, y biomolecula. - Google Patents

Conjugado que comprende ligando, espaciador, enlazador peptido, y biomolecula.

Info

Publication number
MX2021008229A
MX2021008229A MX2021008229A MX2021008229A MX2021008229A MX 2021008229 A MX2021008229 A MX 2021008229A MX 2021008229 A MX2021008229 A MX 2021008229A MX 2021008229 A MX2021008229 A MX 2021008229A MX 2021008229 A MX2021008229 A MX 2021008229A
Authority
MX
Mexico
Prior art keywords
complex
spacer
peptide linker
ligand
biomolecule
Prior art date
Application number
MX2021008229A
Other languages
English (en)
Inventor
Junya Ishida
Toru Asano
Michinori Akaiwa
Yorikata Sano
Hiroki Toya
Tomoaki Yoshikawa
Yukihito Sugano
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2021008229A publication Critical patent/MX2021008229A/es

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

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Abstract

Se proporciona un conjugado que comprende un ligando, un espaciador, y un enlazador péptido útil para un fármaco de diagnóstico in-vivo y terapia de radiación interna, usando un fragmento Fab de anticuerpo MUC1 anti-humano cuya actividad de enlace no se atenúa aún al etiquetar con un metal, un tinte fluorescente, o similares. Un conjugado que comprende 3arm DOTA, un espaciador específico, un enlazador péptido específico, y una biomolécula que incluye un fragmento Fab de anticuerpo MUC1 anti-humano, en donde la actividad de enlace de los mismos no se atenúa aún al etiquetar con un metal, un tinte fluorescente, o similares, se puede usar como una composición diagnóstica y/o una composición farmacéutica.
MX2021008229A 2019-01-07 2020-01-06 Conjugado que comprende ligando, espaciador, enlazador peptido, y biomolecula. MX2021008229A (es)

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JP2019000530 2019-01-07
JP2019206560 2019-11-14
PCT/JP2020/000036 WO2020145227A1 (ja) 2019-01-07 2020-01-06 配位子、スペーサー、ペプチドリンカーおよび生物分子からなる複合体

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MX2021008230A MX2021008230A (es) 2019-01-07 2020-01-06 Conjugado que comprende ligando y fragmento fab de anticuerpo ceacam5.
MX2021008229A MX2021008229A (es) 2019-01-07 2020-01-06 Conjugado que comprende ligando, espaciador, enlazador peptido, y biomolecula.

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WO2019221269A1 (ja) * 2018-05-17 2019-11-21 アステラス製薬株式会社 抗ヒトＭＵＣ１抗体Ｆａｂフラグメント、ペプチドリンカー及び／又は配位子を含む複合体
TWI835880B (zh) 2018-10-10 2024-03-21 日商安斯泰來製藥股份有限公司 含有標識部－抗人類抗體Ｆａｂ片段複合體之醫藥組成物
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CO2021010116A2 (es) 2021-08-09
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AU2020205851A1 (en) 2021-08-12
IL284623A (en) 2021-08-31
JOP20210183A1 (ar) 2023-01-30
ZA202105150B (en) 2023-01-25
US20220096653A1 (en) 2022-03-31
CO2021010115A2 (es) 2021-08-09
EP3909608A1 (en) 2021-11-17
MX2021008230A (es) 2021-08-11
WO2020145228A1 (ja) 2020-07-16
SG11202107400QA (en) 2021-08-30
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CA3125750A1 (en) 2020-07-16
CA3125745A1 (en) 2020-07-16
BR112021013266A2 (pt) 2021-09-14
AU2020207081A1 (en) 2021-08-12
CN113301920A (zh) 2021-08-24
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TW202043288A (zh) 2020-12-01
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SG11202107398QA (en) 2021-08-30
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