CO6270369A2 - Nuevos anticuerpos especificos de los peptidos beta -amiloides y sus usos como agentes de diagnostico o drogas - Google Patents
Nuevos anticuerpos especificos de los peptidos beta -amiloides y sus usos como agentes de diagnostico o drogasInfo
- Publication number
- CO6270369A2 CO6270369A2 CO10050927A CO10050927A CO6270369A2 CO 6270369 A2 CO6270369 A2 CO 6270369A2 CO 10050927 A CO10050927 A CO 10050927A CO 10050927 A CO10050927 A CO 10050927A CO 6270369 A2 CO6270369 A2 CO 6270369A2
- Authority
- CO
- Colombia
- Prior art keywords
- diagnostic
- beta
- specific antibodies
- new specific
- amyloid peptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invencion se refiere a un anticuerpo monoclonal que se une especificamente a la region N-terminal de péptidos Aβ8-x, estando x comprendido desde 11 a 42, y que no reconoce ni Aβ1-40 ni Aβ1-42 y que presenta una elevada afinidad con respecto a péptidos Aβ8-x, tal como se determina mediante la formacion de complejo inmunologico entre el anticuerpo monoclonal y el péptido Aβ8-x.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07119537 | 2007-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6270369A2 true CO6270369A2 (es) | 2011-04-20 |
Family
ID=38925731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10050927A CO6270369A2 (es) | 2007-10-29 | 2010-04-29 | Nuevos anticuerpos especificos de los peptidos beta -amiloides y sus usos como agentes de diagnostico o drogas |
Country Status (27)
Country | Link |
---|---|
US (1) | US8343493B2 (es) |
EP (1) | EP2205633A1 (es) |
JP (1) | JP5421277B2 (es) |
KR (1) | KR20100097651A (es) |
CN (1) | CN101883792B (es) |
AP (1) | AP2957A (es) |
AR (1) | AR069085A1 (es) |
AU (1) | AU2008317705B2 (es) |
CA (1) | CA2703825A1 (es) |
CL (1) | CL2008003197A1 (es) |
CO (1) | CO6270369A2 (es) |
CR (1) | CR11396A (es) |
EA (1) | EA201070539A1 (es) |
EC (1) | ECSP10010142A (es) |
HN (1) | HN2010000880A (es) |
IL (1) | IL205398A0 (es) |
MA (1) | MA31793B1 (es) |
MX (1) | MX2010004660A (es) |
MY (1) | MY155144A (es) |
NI (1) | NI201000075A (es) |
NZ (1) | NZ585000A (es) |
TN (1) | TN2010000197A1 (es) |
TW (1) | TW200936605A (es) |
UA (1) | UA103602C2 (es) |
UY (1) | UY31433A1 (es) |
WO (1) | WO2009056490A1 (es) |
ZA (1) | ZA201002989B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103408661B (zh) * | 2007-01-05 | 2016-04-06 | 苏黎世大学 | 提供疾患特异性结合分子和靶的方法 |
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
MX2011006422A (es) | 2008-12-19 | 2011-09-15 | Panima Pharmaceuticals Ag | Autoanticuerpos humanos anti-alfa-sinucleina. |
DK2475428T3 (en) | 2009-09-11 | 2015-09-28 | Probiodrug Ag | Heterocyclic derivatives as glutaminylcyklaseinhibitorer |
AP2012006359A0 (en) | 2010-03-03 | 2012-08-31 | Boehringer Ingelheim Int | Biparatopic abeta binding polypeptides |
EP2511296A1 (en) * | 2011-04-12 | 2012-10-17 | Araclón Biotech, S. L. | Antibody, kit and method for determination of amyloid peptides |
PL2723379T3 (pl) | 2011-06-23 | 2019-05-31 | Biogen Int Neuroscience Gmbh | Cząsteczki wiążące przeciwko alfa-synukleinie |
DK3269736T3 (da) | 2012-05-10 | 2020-01-13 | Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin | Konformationsspecifikke antistoffer mod oligomerer af amyloid beta |
MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
CA3004494A1 (en) * | 2015-11-09 | 2017-05-18 | The University Of British Columiba | Epitopes in amyloid beta mid-region and conformationally-selective antibodies thereto |
WO2018017754A1 (en) | 2016-07-19 | 2018-01-25 | Duke University | Therapeutic applications of cpf1-based genome editing |
MA49947B1 (fr) | 2017-08-22 | 2023-03-31 | Biogen Ma Inc | Compositions pharmaceutiques contenant des anticorps anti-bêta-amyloïdes |
EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
WO2023111168A1 (en) * | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013172A2 (en) | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
-
2008
- 2008-10-24 NZ NZ585000A patent/NZ585000A/xx not_active IP Right Cessation
- 2008-10-24 MY MYPI2010001941A patent/MY155144A/en unknown
- 2008-10-24 US US12/740,217 patent/US8343493B2/en not_active Expired - Fee Related
- 2008-10-24 UA UAA201006547A patent/UA103602C2/ru unknown
- 2008-10-24 WO PCT/EP2008/064432 patent/WO2009056490A1/en active Application Filing
- 2008-10-24 AP AP2010005249A patent/AP2957A/xx active
- 2008-10-24 UY UY31433A patent/UY31433A1/es unknown
- 2008-10-24 EA EA201070539A patent/EA201070539A1/ru unknown
- 2008-10-24 JP JP2010531496A patent/JP5421277B2/ja not_active Expired - Fee Related
- 2008-10-24 CA CA2703825A patent/CA2703825A1/en not_active Abandoned
- 2008-10-24 CN CN200880119109.XA patent/CN101883792B/zh not_active Expired - Fee Related
- 2008-10-24 MX MX2010004660A patent/MX2010004660A/es active IP Right Grant
- 2008-10-24 AU AU2008317705A patent/AU2008317705B2/en not_active Ceased
- 2008-10-24 KR KR1020107009533A patent/KR20100097651A/ko not_active Application Discontinuation
- 2008-10-24 EP EP08844119A patent/EP2205633A1/en not_active Withdrawn
- 2008-10-27 TW TW097141147A patent/TW200936605A/zh unknown
- 2008-10-28 CL CL2008003197A patent/CL2008003197A1/es unknown
- 2008-10-28 AR ARP080104708A patent/AR069085A1/es unknown
-
2010
- 2010-04-28 IL IL205398A patent/IL205398A0/en unknown
- 2010-04-28 HN HN2010000880A patent/HN2010000880A/es unknown
- 2010-04-28 CR CR11396A patent/CR11396A/es unknown
- 2010-04-29 CO CO10050927A patent/CO6270369A2/es active IP Right Grant
- 2010-04-29 ZA ZA2010/02989A patent/ZA201002989B/en unknown
- 2010-04-29 NI NI201000075A patent/NI201000075A/es unknown
- 2010-04-29 MA MA32798A patent/MA31793B1/fr unknown
- 2010-04-29 TN TN2010000197A patent/TN2010000197A1/fr unknown
- 2010-04-29 EC EC2010010142A patent/ECSP10010142A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AP2957A (en) | 2014-08-31 |
CA2703825A1 (en) | 2009-05-07 |
JP5421277B2 (ja) | 2014-02-19 |
ZA201002989B (en) | 2011-07-27 |
AR069085A1 (es) | 2009-12-30 |
TN2010000197A1 (en) | 2011-11-11 |
AU2008317705B2 (en) | 2014-06-05 |
KR20100097651A (ko) | 2010-09-03 |
CL2008003197A1 (es) | 2010-01-15 |
WO2009056490A1 (en) | 2009-05-07 |
UA103602C2 (ru) | 2013-11-11 |
UY31433A1 (es) | 2009-05-29 |
US8343493B2 (en) | 2013-01-01 |
MA31793B1 (fr) | 2010-10-01 |
EA201070539A1 (ru) | 2010-10-29 |
TW200936605A (en) | 2009-09-01 |
EP2205633A1 (en) | 2010-07-14 |
US20110059092A1 (en) | 2011-03-10 |
AP2010005249A0 (en) | 2010-06-30 |
MX2010004660A (es) | 2010-07-30 |
HN2010000880A (es) | 2014-03-10 |
NZ585000A (en) | 2012-08-31 |
JP2011502139A (ja) | 2011-01-20 |
MY155144A (en) | 2015-09-15 |
NI201000075A (es) | 2010-09-23 |
IL205398A0 (en) | 2010-12-30 |
CR11396A (es) | 2012-10-18 |
CN101883792B (zh) | 2014-08-27 |
AU2008317705A1 (en) | 2009-05-07 |
ECSP10010142A (es) | 2010-07-30 |
CN101883792A (zh) | 2010-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Application granted |