NI201000075A - NUEVOS ANTICUERPOS ESPECÍFICOS DE LOS PEPTIDOS Beta-AMILOIDES Y SUS USOS COMO AGENTES DE DIAGNÓSTICO O DROGAS. - Google Patents
NUEVOS ANTICUERPOS ESPECÍFICOS DE LOS PEPTIDOS Beta-AMILOIDES Y SUS USOS COMO AGENTES DE DIAGNÓSTICO O DROGAS.Info
- Publication number
- NI201000075A NI201000075A NI201000075A NI201000075A NI201000075A NI 201000075 A NI201000075 A NI 201000075A NI 201000075 A NI201000075 A NI 201000075A NI 201000075 A NI201000075 A NI 201000075A NI 201000075 A NI201000075 A NI 201000075A
- Authority
- NI
- Nicaragua
- Prior art keywords
- drugs
- beta
- antibodies specific
- sub
- diagnostic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un anticuerpo monoclonal que se une específicamente a la región N-terminal de péptidos ABeta(sub 8-X) estando X comprendido desde 11 a 42, y que no reconoce ni ABeta(sub 1-40) ni ABeta(sub 1-42) y que presenta una elevada afinidad con respecto a péptidos ABeta(sub 8-X) tal como se determina mediante la formación de complejo inmunológico entre el anticuerpo monoclonal y el péptido ABeta(sub 8-X).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07119537 | 2007-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201000075A true NI201000075A (es) | 2010-09-23 |
Family
ID=38925731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201000075A NI201000075A (es) | 2007-10-29 | 2010-04-29 | NUEVOS ANTICUERPOS ESPECÍFICOS DE LOS PEPTIDOS Beta-AMILOIDES Y SUS USOS COMO AGENTES DE DIAGNÓSTICO O DROGAS. |
Country Status (27)
Country | Link |
---|---|
US (1) | US8343493B2 (es) |
EP (1) | EP2205633A1 (es) |
JP (1) | JP5421277B2 (es) |
KR (1) | KR20100097651A (es) |
CN (1) | CN101883792B (es) |
AP (1) | AP2957A (es) |
AR (1) | AR069085A1 (es) |
AU (1) | AU2008317705B2 (es) |
CA (1) | CA2703825A1 (es) |
CL (1) | CL2008003197A1 (es) |
CO (1) | CO6270369A2 (es) |
CR (1) | CR11396A (es) |
EA (1) | EA201070539A1 (es) |
EC (1) | ECSP10010142A (es) |
HN (1) | HN2010000880A (es) |
IL (1) | IL205398A0 (es) |
MA (1) | MA31793B1 (es) |
MX (1) | MX2010004660A (es) |
MY (1) | MY155144A (es) |
NI (1) | NI201000075A (es) |
NZ (1) | NZ585000A (es) |
TN (1) | TN2010000197A1 (es) |
TW (1) | TW200936605A (es) |
UA (1) | UA103602C2 (es) |
UY (1) | UY31433A1 (es) |
WO (1) | WO2009056490A1 (es) |
ZA (1) | ZA201002989B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA029481B1 (ru) * | 2007-01-05 | 2018-04-30 | Юнивэсэти Оф Цюрих | Способ получения человеческого рекомбинантного антитела, специфично связывающего вариант эндогенного белка, формирующий аномальные патологические белковые структуры путем агрегации, олигомеризации или образования фибрилл |
IL199534A (en) | 2007-01-05 | 2013-01-31 | Univ Zuerich | An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses. |
EP2949666B1 (en) | 2008-12-19 | 2018-12-19 | Biogen International Neuroscience GmbH | Human anti-alpha-synuclein antibodies |
MX2012002993A (es) | 2009-09-11 | 2012-04-19 | Probiodrug Ag | Derivados heterociclicos como inhibidores de ciclasa glutaminilo. |
PE20130527A1 (es) | 2010-03-03 | 2013-05-09 | Boehringer Ingelheim Int | Polipeptidos de union a a-beta biparatopicos |
EP2511296A1 (en) * | 2011-04-12 | 2012-10-17 | Araclón Biotech, S. L. | Antibody, kit and method for determination of amyloid peptides |
AU2012272790B2 (en) | 2011-06-23 | 2016-10-06 | Biogen International Neuroscience Gmbh | Anti-alpha synuclein binding molecules |
EP2847217B1 (en) | 2012-05-10 | 2017-10-11 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | CONFORMATIONAL-SPECIFIC ANTIBODIES AGAINST OLIGOMERS of Amyloid beta |
MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
KR20180085736A (ko) * | 2015-11-09 | 2018-07-27 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타 중간-영역 내 에피토프 및 이에 대해 구조적으로 선택성인 항체 |
EP3487523B1 (en) | 2016-07-19 | 2023-09-06 | Duke University | Therapeutic applications of cpf1-based genome editing |
FI3672631T3 (fi) | 2017-08-22 | 2023-06-29 | Biogen Ma Inc | Beeta-amyloidin vasta-aineita sisältäviä lääkekoostumuksia |
ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
WO2023111168A1 (en) * | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1523499A2 (en) * | 2002-07-24 | 2005-04-20 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
-
2008
- 2008-10-24 CN CN200880119109.XA patent/CN101883792B/zh not_active Expired - Fee Related
- 2008-10-24 US US12/740,217 patent/US8343493B2/en not_active Expired - Fee Related
- 2008-10-24 AP AP2010005249A patent/AP2957A/xx active
- 2008-10-24 AU AU2008317705A patent/AU2008317705B2/en not_active Ceased
- 2008-10-24 EP EP08844119A patent/EP2205633A1/en not_active Withdrawn
- 2008-10-24 UY UY31433A patent/UY31433A1/es unknown
- 2008-10-24 KR KR1020107009533A patent/KR20100097651A/ko not_active Application Discontinuation
- 2008-10-24 MY MYPI2010001941A patent/MY155144A/en unknown
- 2008-10-24 MX MX2010004660A patent/MX2010004660A/es active IP Right Grant
- 2008-10-24 CA CA2703825A patent/CA2703825A1/en not_active Abandoned
- 2008-10-24 EA EA201070539A patent/EA201070539A1/ru unknown
- 2008-10-24 WO PCT/EP2008/064432 patent/WO2009056490A1/en active Application Filing
- 2008-10-24 NZ NZ585000A patent/NZ585000A/xx not_active IP Right Cessation
- 2008-10-24 UA UAA201006547A patent/UA103602C2/ru unknown
- 2008-10-24 JP JP2010531496A patent/JP5421277B2/ja not_active Expired - Fee Related
- 2008-10-27 TW TW097141147A patent/TW200936605A/zh unknown
- 2008-10-28 CL CL2008003197A patent/CL2008003197A1/es unknown
- 2008-10-28 AR ARP080104708A patent/AR069085A1/es unknown
-
2010
- 2010-04-28 CR CR11396A patent/CR11396A/es unknown
- 2010-04-28 HN HN2010000880A patent/HN2010000880A/es unknown
- 2010-04-28 IL IL205398A patent/IL205398A0/en unknown
- 2010-04-29 TN TN2010000197A patent/TN2010000197A1/fr unknown
- 2010-04-29 CO CO10050927A patent/CO6270369A2/es active IP Right Grant
- 2010-04-29 NI NI201000075A patent/NI201000075A/es unknown
- 2010-04-29 ZA ZA2010/02989A patent/ZA201002989B/en unknown
- 2010-04-29 EC EC2010010142A patent/ECSP10010142A/es unknown
- 2010-04-29 MA MA32798A patent/MA31793B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
HN2010000880A (es) | 2014-03-10 |
CO6270369A2 (es) | 2011-04-20 |
AP2957A (en) | 2014-08-31 |
TN2010000197A1 (en) | 2011-11-11 |
AU2008317705A1 (en) | 2009-05-07 |
TW200936605A (en) | 2009-09-01 |
MX2010004660A (es) | 2010-07-30 |
JP2011502139A (ja) | 2011-01-20 |
CA2703825A1 (en) | 2009-05-07 |
WO2009056490A1 (en) | 2009-05-07 |
EP2205633A1 (en) | 2010-07-14 |
US20110059092A1 (en) | 2011-03-10 |
CL2008003197A1 (es) | 2010-01-15 |
ECSP10010142A (es) | 2010-07-30 |
MY155144A (en) | 2015-09-15 |
AU2008317705B2 (en) | 2014-06-05 |
UA103602C2 (ru) | 2013-11-11 |
JP5421277B2 (ja) | 2014-02-19 |
AR069085A1 (es) | 2009-12-30 |
IL205398A0 (en) | 2010-12-30 |
KR20100097651A (ko) | 2010-09-03 |
US8343493B2 (en) | 2013-01-01 |
CN101883792B (zh) | 2014-08-27 |
UY31433A1 (es) | 2009-05-29 |
CR11396A (es) | 2012-10-18 |
CN101883792A (zh) | 2010-11-10 |
MA31793B1 (fr) | 2010-10-01 |
EA201070539A1 (ru) | 2010-10-29 |
ZA201002989B (en) | 2011-07-27 |
NZ585000A (en) | 2012-08-31 |
AP2010005249A0 (en) | 2010-06-30 |
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