PH12021551631A1 - Conjugate comprising ligand, spacer, peptide linker, and biomolecule - Google Patents

Conjugate comprising ligand, spacer, peptide linker, and biomolecule

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Publication number
PH12021551631A1
PH12021551631A1 PH1/2021/551631A PH12021551631A PH12021551631A1 PH 12021551631 A1 PH12021551631 A1 PH 12021551631A1 PH 12021551631 A PH12021551631 A PH 12021551631A PH 12021551631 A1 PH12021551631 A1 PH 12021551631A1
Authority
PH
Philippines
Prior art keywords
spacer
peptide linker
ligand
biomolecule
conjugate
Prior art date
Application number
PH1/2021/551631A
Other languages
English (en)
Inventor
Michinori Akaiwa
Toru Asano
Junya Ishida
Yorikata Sano
Yukihito Sugano
Hiroki Toya
Tomoaki Yoshikawa
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=71520276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH12021551631(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of PH12021551631A1 publication Critical patent/PH12021551631A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

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PH1/2021/551631A 2019-01-07 2020-01-06 Conjugate comprising ligand, spacer, peptide linker, and biomolecule PH12021551631A1 (en)

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TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
MX2020012351A (es) * 2018-05-17 2021-01-29 Astellas Pharma Inc Complejo que tiene fragmento fab de anticuerpo anti-muc1 de humano, enlazador peptido y/o ligando.
CA3115747A1 (en) 2018-10-10 2020-04-16 Astellas Pharma Inc. Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex
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KR20230154183A (ko) 2021-03-04 2023-11-07 니혼 메디피직스 가부시키가이샤 화합물 및 방사성 표지 화합물
CN118852044A (zh) * 2021-09-03 2024-10-29 晶核生物医药科技(南京)有限公司 一种肽脲素衍生物、含其的药物组合物及其应用
EP4536278A2 (en) * 2022-06-07 2025-04-16 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
CA3265394A1 (en) * 2022-08-22 2024-02-29 Abdera Therapeutics Inc. VHH ANTIBODY CONJUGATES
WO2024235134A1 (zh) * 2023-05-12 2024-11-21 四川科伦博泰生物医药股份有限公司 具有靶向作用的偶联物及其制备方法和用途
WO2024243315A2 (en) * 2023-05-22 2024-11-28 Actinium Pharmaceuticals, Inc. Multi-arm bifunctional chelators
WO2025232116A1 (zh) * 2024-05-10 2025-11-13 四川科伦博泰生物医药股份有限公司 具有靶向作用的偶联物及其制备方法和用途
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TWI780082B (zh) 2016-11-18 2022-10-11 日商安斯泰來製藥股份有限公司 新穎抗人類ＭＵＣ１抗體Ｆａｂ片段
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MX2021008229A (es) 2021-08-11
AU2020205851A1 (en) 2021-08-12
US20220096653A1 (en) 2022-03-31
ZA202105150B (en) 2023-01-25
CN113301920B (zh) 2025-01-14
KR20210113201A (ko) 2021-09-15
EP3909606A4 (en) 2023-01-18
IL284623B2 (en) 2025-04-01
CN113301920A (zh) 2021-08-24
JPWO2020145227A1 (ja) 2021-11-11
BR112021013361A2 (pt) 2021-10-19
BR112021013266A2 (pt) 2021-09-14
EP3909608A1 (en) 2021-11-17
ZA202105151B (en) 2023-01-25
JOP20210183A1 (ar) 2023-01-30
IL284623A (en) 2021-08-31
PH12021551627A1 (en) 2022-05-02
JP7414370B2 (ja) 2024-01-16
TW202043288A (zh) 2020-12-01
CA3125750A1 (en) 2020-07-16
JPWO2020145228A1 (ja) 2021-11-11
CN113271973A (zh) 2021-08-17
WO2020145228A1 (ja) 2020-07-16
JOP20210180A1 (ar) 2023-01-30
TW202043289A (zh) 2020-12-01
IL284622A (en) 2021-08-31
AU2020207081A1 (en) 2021-08-12
TWI850308B (zh) 2024-08-01
EP3909606A1 (en) 2021-11-17
WO2020145227A1 (ja) 2020-07-16
SG11202107400QA (en) 2021-08-30
EP3909608A4 (en) 2023-03-08
KR20210113202A (ko) 2021-09-15
SG11202107398QA (en) 2021-08-30
IL284623B1 (en) 2024-12-01
CA3125745A1 (en) 2020-07-16
AU2020205851B2 (en) 2025-12-11

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