CA3125745A1 - Conjugate comprising ligand, spacer, peptide linker, and biomolecule - Google Patents

Conjugate comprising ligand, spacer, peptide linker, and biomolecule Download PDF

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Publication number
CA3125745A1
CA3125745A1 CA3125745A CA3125745A CA3125745A1 CA 3125745 A1 CA3125745 A1 CA 3125745A1 CA 3125745 A CA3125745 A CA 3125745A CA 3125745 A CA3125745 A CA 3125745A CA 3125745 A1 CA3125745 A1 CA 3125745A1
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CA
Canada
Prior art keywords
seq
conjugate
amino acid
cancer
fab fragment
Prior art date
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Pending
Application number
CA3125745A
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English (en)
French (fr)
Inventor
Michinori AKAIWA
Junya Ishida
Hiroki Toya
Toru Asano
Tomoaki Yoshikawa
Yorikata Sano
Yukihito Sugano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
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Astellas Pharma Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=71520276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3125745(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of CA3125745A1 publication Critical patent/CA3125745A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
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    • A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

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CA3125745A 2019-01-07 2020-01-06 Conjugate comprising ligand, spacer, peptide linker, and biomolecule Pending CA3125745A1 (en)

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TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
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ZA202105150B (en) 2023-01-25
BR112021013361A2 (pt) 2021-10-19
AU2020205851A1 (en) 2021-08-12
IL284623A (en) 2021-08-31
CO2021010115A2 (es) 2021-08-09
US20220096653A1 (en) 2022-03-31
CN113301920B (zh) 2025-01-14
CA3125750A1 (en) 2020-07-16
EP3909606A4 (en) 2023-01-18
CO2021010116A2 (es) 2021-08-09
TW202043289A (zh) 2020-12-01
JPWO2020145227A1 (ja) 2021-11-11
TWI850308B (zh) 2024-08-01
ZA202105151B (en) 2023-01-25
CN113301920A (zh) 2021-08-24
KR20210113202A (ko) 2021-09-15
EP3909608A4 (en) 2023-03-08
CN113271973A (zh) 2021-08-17
JP7414370B2 (ja) 2024-01-16
KR20210113201A (ko) 2021-09-15
WO2020145228A1 (ja) 2020-07-16
MX2021008230A (es) 2021-08-11
SG11202107400QA (en) 2021-08-30
PH12021551631A1 (en) 2022-05-02
AU2020207081A1 (en) 2021-08-12
IL284623B2 (en) 2025-04-01
IL284622A (en) 2021-08-31
WO2020145227A1 (ja) 2020-07-16
AU2020205851B2 (en) 2025-12-11
TW202043288A (zh) 2020-12-01
SG11202107398QA (en) 2021-08-30
EP3909606A1 (en) 2021-11-17
JOP20210183A1 (ar) 2023-01-30
EP3909608A1 (en) 2021-11-17
BR112021013266A2 (pt) 2021-09-14
MX2021008229A (es) 2021-08-11
IL284623B1 (en) 2024-12-01

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