KR20200141442A - 구강용 조성물 및 α-올레핀술폰산염의 고미 개선제 - Google Patents
구강용 조성물 및 α-올레핀술폰산염의 고미 개선제 Download PDFInfo
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- KR20200141442A KR20200141442A KR1020207027262A KR20207027262A KR20200141442A KR 20200141442 A KR20200141442 A KR 20200141442A KR 1020207027262 A KR1020207027262 A KR 1020207027262A KR 20207027262 A KR20207027262 A KR 20207027262A KR 20200141442 A KR20200141442 A KR 20200141442A
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- KR
- South Korea
- Prior art keywords
- component
- oral composition
- olefin sulfonate
- bitter taste
- linalool
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 235000019658 bitter taste Nutrition 0.000 title claims abstract description 48
- 239000004711 α-olefin Substances 0.000 title claims abstract description 36
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 title claims abstract description 31
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 claims abstract description 28
- KVWWIYGFBYDJQC-UHFFFAOYSA-N methyl dihydrojasmonate Chemical compound CCCCCC1C(CC(=O)OC)CCC1=O KVWWIYGFBYDJQC-UHFFFAOYSA-N 0.000 claims abstract description 28
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 claims abstract description 15
- 239000001278 2-(5-ethenyl-5-methyloxolan-2-yl)propan-2-ol Substances 0.000 claims abstract description 15
- BRHDDEIRQPDPMG-UHFFFAOYSA-N Linalyl oxide Chemical compound CC(C)(O)C1CCC(C)(C=C)O1 BRHDDEIRQPDPMG-UHFFFAOYSA-N 0.000 claims abstract description 15
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- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 15
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 15
- UFLHIIWVXFIJGU-UHFFFAOYSA-N hex-3-en-1-ol Natural products CCC=CCCO UFLHIIWVXFIJGU-UHFFFAOYSA-N 0.000 claims abstract description 15
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims abstract description 14
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims abstract description 13
- 229930007744 linalool Natural products 0.000 claims abstract description 13
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 26
- GEWDNTWNSAZUDX-WQMVXFAESA-N (-)-methyl jasmonate Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-WQMVXFAESA-N 0.000 claims description 13
- 239000005792 Geraniol Substances 0.000 claims description 13
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 13
- 229940113087 geraniol Drugs 0.000 claims description 13
- GEWDNTWNSAZUDX-UHFFFAOYSA-N methyl 7-epi-jasmonate Natural products CCC=CCC1C(CC(=O)OC)CCC1=O GEWDNTWNSAZUDX-UHFFFAOYSA-N 0.000 claims description 13
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 8
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 8
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 8
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 8
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 6
- 239000000551 dentifrice Substances 0.000 claims description 5
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 claims description 3
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- CCXAYLQLOLXXKE-DWJAGBRCSA-K trisodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-t Chemical compound [Na+].[Na+].[Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O CCXAYLQLOLXXKE-DWJAGBRCSA-K 0.000 claims description 3
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Landscapes
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- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
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JPJP-P-2018-073609 | 2018-04-06 | ||
PCT/JP2019/013611 WO2019194068A1 (ja) | 2018-04-06 | 2019-03-28 | 口腔用組成物及びα-オレフィンスルホン酸塩の苦味改善剤 |
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KR20200141442A true KR20200141442A (ko) | 2020-12-18 |
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JP (1) | JP7255587B2 (ja) |
KR (1) | KR20200141442A (ja) |
CN (1) | CN111902125B (ja) |
WO (1) | WO2019194068A1 (ja) |
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JP7331182B2 (ja) * | 2017-10-12 | 2023-08-22 | サンスター株式会社 | シリカ含有口腔用組成物 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5825093B2 (ja) | 1975-06-23 | 1983-05-25 | 住友ベークライト株式会社 | フエノ−ルジユシハツポウタイノ セイゾウホウホウ |
JPS607781B2 (ja) | 1976-05-18 | 1985-02-27 | 石原産業株式会社 | 電子写真用感光材料 |
JP2015020970A (ja) | 2013-07-18 | 2015-02-02 | ライオン株式会社 | 口腔バイオフィルム除去剤及び口腔用組成物 |
WO2017094582A1 (ja) | 2015-11-30 | 2017-06-08 | ライオン株式会社 | 口腔用組成物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS62234010A (ja) * | 1986-04-03 | 1987-10-14 | Lion Corp | 口腔用組成物 |
JPH01165516A (ja) * | 1987-12-23 | 1989-06-29 | Lion Corp | 口腔用組成物 |
JPH09132517A (ja) * | 1995-11-09 | 1997-05-20 | Lion Corp | 口腔用組成物 |
JP2001064136A (ja) * | 1999-08-26 | 2001-03-13 | Kao Corp | 口腔用組成物 |
JP5057646B2 (ja) * | 2004-12-10 | 2012-10-24 | 株式会社ノエビア | チロシナーゼ活性抑制剤、及び皮膚外用剤 |
JP5041761B2 (ja) * | 2005-08-10 | 2012-10-03 | ロート製薬株式会社 | 眼粘膜適用製剤 |
JP4893124B2 (ja) * | 2006-06-27 | 2012-03-07 | ライオン株式会社 | 液状口腔用組成物 |
JP5874383B2 (ja) * | 2011-12-21 | 2016-03-02 | ライオン株式会社 | 口腔用組成物 |
JP6007781B2 (ja) * | 2011-12-26 | 2016-10-12 | ライオン株式会社 | 口腔用組成物及び口腔バイオフィルム除去剤 |
DE102013204088A1 (de) * | 2013-03-11 | 2014-09-11 | Beiersdorf Ag | Wirkstoffkombinationen aus Alkylamidothiazolen und einen oder mehreren kosmetisch oder dermatologisch relevanten Duftstoffen |
JP6451392B2 (ja) * | 2015-02-19 | 2019-01-16 | ライオン株式会社 | 口腔用組成物 |
-
2019
- 2019-03-28 WO PCT/JP2019/013611 patent/WO2019194068A1/ja active Application Filing
- 2019-03-28 KR KR1020207027262A patent/KR20200141442A/ko not_active Application Discontinuation
- 2019-03-28 CN CN201980021567.8A patent/CN111902125B/zh active Active
- 2019-03-28 JP JP2020512201A patent/JP7255587B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5825093B2 (ja) | 1975-06-23 | 1983-05-25 | 住友ベークライト株式会社 | フエノ−ルジユシハツポウタイノ セイゾウホウホウ |
JPS607781B2 (ja) | 1976-05-18 | 1985-02-27 | 石原産業株式会社 | 電子写真用感光材料 |
JP2015020970A (ja) | 2013-07-18 | 2015-02-02 | ライオン株式会社 | 口腔バイオフィルム除去剤及び口腔用組成物 |
WO2017094582A1 (ja) | 2015-11-30 | 2017-06-08 | ライオン株式会社 | 口腔用組成物 |
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CN111902125B (zh) | 2023-10-20 |
JP7255587B2 (ja) | 2023-04-11 |
CN111902125A (zh) | 2020-11-06 |
WO2019194068A1 (ja) | 2019-10-10 |
JPWO2019194068A1 (ja) | 2021-04-08 |
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