KR20200088445A - 세포 조성물 및 치료 방법 i - Google Patents
세포 조성물 및 치료 방법 i Download PDFInfo
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- KR20200088445A KR20200088445A KR1020207017952A KR20207017952A KR20200088445A KR 20200088445 A KR20200088445 A KR 20200088445A KR 1020207017952 A KR1020207017952 A KR 1020207017952A KR 20207017952 A KR20207017952 A KR 20207017952A KR 20200088445 A KR20200088445 A KR 20200088445A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01214—Glycoprotein 3-alpha-L-fucosyltransferase (2.4.1.214)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020257011154A KR20250051794A (ko) | 2017-11-22 | 2018-11-21 | 세포 조성물 및 치료 방법 i |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589764P | 2017-11-22 | 2017-11-22 | |
| US62/589,764 | 2017-11-22 | ||
| PCT/IB2018/001439 WO2019102268A1 (en) | 2017-11-22 | 2018-11-21 | Cellular compositions and methods of treatment i |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257011154A Division KR20250051794A (ko) | 2017-11-22 | 2018-11-21 | 세포 조성물 및 치료 방법 i |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200088445A true KR20200088445A (ko) | 2020-07-22 |
Family
ID=65003422
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257011154A Pending KR20250051794A (ko) | 2017-11-22 | 2018-11-21 | 세포 조성물 및 치료 방법 i |
| KR1020207017952A Ceased KR20200088445A (ko) | 2017-11-22 | 2018-11-21 | 세포 조성물 및 치료 방법 i |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257011154A Pending KR20250051794A (ko) | 2017-11-22 | 2018-11-21 | 세포 조성물 및 치료 방법 i |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12473547B2 (enExample) |
| EP (1) | EP3714038A1 (enExample) |
| JP (2) | JP7463275B2 (enExample) |
| KR (2) | KR20250051794A (enExample) |
| CN (2) | CN112004923A (enExample) |
| AU (1) | AU2018372631B2 (enExample) |
| BR (1) | BR112020010079A2 (enExample) |
| CA (1) | CA3084575A1 (enExample) |
| SG (1) | SG11202004680UA (enExample) |
| WO (1) | WO2019102268A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2893204C (en) | 2006-01-13 | 2016-11-29 | Alla Danilkovitch | Mesenchymal stem cells expressing tnf-.alpha. receptors |
| EP4663241A2 (en) | 2010-10-08 | 2025-12-17 | Mesoblast International Sàrl | Enhanced msc preparations |
| WO2019102268A1 (en) | 2017-11-22 | 2019-05-31 | Mesoblast International Sarl | Cellular compositions and methods of treatment i |
| CN112654705B (zh) * | 2018-09-11 | 2024-07-02 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | 用在治疗代谢疾病中的微小rna抑制剂 |
| CN113881770B (zh) * | 2020-03-30 | 2022-04-12 | 中国医学科学院肿瘤医院 | 肺癌诊断的试剂盒和装置 |
| CN112067805B (zh) * | 2020-08-25 | 2023-08-22 | 南通大学 | 一种β-1,4-半乳糖基转移酶-IsiRNA在克服肝癌化疗耐药药物中的应用 |
| CN113025714B (zh) * | 2021-03-23 | 2022-05-24 | 华中科技大学同济医学院附属同济医院 | 用于甲状腺乳头状癌颈侧方淋巴结转移诊断的miRNA生物标志物及检测试剂盒 |
| WO2023019128A1 (en) * | 2021-08-09 | 2023-02-16 | The Trustees Of The University Of Pennyslvania | Optimizing t cell differentiation state with micrornas |
| CN114085817B (zh) * | 2021-11-26 | 2025-04-15 | 三代康年(上海)医疗科技有限公司 | 一种包载microRNA的外泌体的制备方法及其产品和应用 |
| US20250333758A1 (en) * | 2021-12-15 | 2025-10-30 | Genans Biotechnology Co., Ltd | Microglia having car and use thereof |
| US20240318185A1 (en) * | 2023-03-20 | 2024-09-26 | MAM Holdings of West Florida, L.L.C. | Mesenchymal stem cell-derived microribonucleic acid-mediated treatments for the prevention and targeted treatment of cancer and other disorders |
| CN118831092A (zh) * | 2024-09-19 | 2024-10-25 | 天津市第五中心医院 | miR-200b-3p在制备治疗子宫内膜癌的药物中的应用 |
| CN119144728B (zh) * | 2024-11-19 | 2025-04-29 | 四川大学华西医院 | 原发性肝癌的MicroRNA标志物的引物、试剂盒和应用 |
Family Cites Families (175)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5578475A (en) | 1993-07-12 | 1996-11-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| JPH10505250A (ja) | 1994-06-06 | 1998-05-26 | ケース ウエスターン リザーブ ユニバーシティ | 組織再生のためのバイオマトリックス |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5643736A (en) | 1995-02-06 | 1997-07-01 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human osteogenic cell surface antigens |
| US6653134B2 (en) | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
| US6974571B2 (en) | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
| ATE241369T1 (de) | 1995-03-28 | 2003-06-15 | Univ Jefferson | Isolierte stromazellen und methoden zu deren verwendung |
| US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
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| JP2023517641A (ja) | 2020-03-11 | 2023-04-26 | メゾブラスト・インターナショナル・エスアーエールエル | 炎症性腸疾患を治療するための方法ii |
| WO2021198454A1 (en) | 2020-04-03 | 2021-10-07 | Mesoblast International Sàrl | Method for treating hyperinflammation using mesenchymal lineage precursor or stem cells |
| KR20230022242A (ko) | 2020-06-11 | 2023-02-14 | 메조블라스트 인터내셔널 에스에이알엘 | 중간엽 계통 전구세포 또는 줄기세포의 3차원 배양 |
| US20230293590A1 (en) | 2020-08-10 | 2023-09-21 | Mesoblast International Sárl | Cellular compositions and methods of treatment |
| CN116057173A (zh) | 2020-08-10 | 2023-05-02 | 迈索布拉斯特国际有限公司 | 包括间充质前体细胞或干细胞的组合物及其用途 |
| AU2021403025A1 (en) | 2020-12-15 | 2023-07-20 | Mesoblast International Sarl | Method of treating progressive heart failure in subjects with class ii heart failure |
| CN112522191B (zh) | 2020-12-18 | 2023-05-12 | 云南中科灵长类生物医学重点实验室 | 一种间充质干细胞的培养方法 |
| JP2024504148A (ja) | 2021-01-22 | 2024-01-30 | メゾブラスト・インターナショナル・エスアーエールエル | オピオイド節減組成物及びその使用方法 |
| WO2022224207A1 (en) | 2021-04-23 | 2022-10-27 | Mesoblast International Sarl | Method for treating acute respiratory distress syndrome (ards) using mesenchymal lineage precursor or stem cells |
| CN120603931A (zh) | 2022-12-09 | 2025-09-05 | 迈索布拉斯特国际有限公司 | 预先许可的组合物和细胞培养方法 |
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| EP3714038A1 (en) | 2020-09-30 |
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| CA3084575A1 (en) | 2019-05-31 |
| BR112020010079A2 (pt) | 2020-11-03 |
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