KR20190058550A - 병용 요법 - Google Patents

병용 요법 Download PDF

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Publication number
KR20190058550A
KR20190058550A KR1020197011397A KR20197011397A KR20190058550A KR 20190058550 A KR20190058550 A KR 20190058550A KR 1020197011397 A KR1020197011397 A KR 1020197011397A KR 20197011397 A KR20197011397 A KR 20197011397A KR 20190058550 A KR20190058550 A KR 20190058550A
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KR
South Korea
Prior art keywords
certain embodiments
substituents
optionally substituted
alkyl
hydrogen
Prior art date
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Ceased
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KR1020197011397A
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English (en)
Korean (ko)
Inventor
다니엘 피 골드
Original Assignee
메이 파마, 아이엔씨.
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Application filed by 메이 파마, 아이엔씨. filed Critical 메이 파마, 아이엔씨.
Publication of KR20190058550A publication Critical patent/KR20190058550A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
KR1020197011397A 2016-09-19 2017-09-18 병용 요법 Ceased KR20190058550A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662396734P 2016-09-19 2016-09-19
US62/396,734 2016-09-19
US201662412720P 2016-10-25 2016-10-25
US62/412,720 2016-10-25
PCT/US2017/052086 WO2018053437A1 (en) 2016-09-19 2017-09-18 Combination therapy

Publications (1)

Publication Number Publication Date
KR20190058550A true KR20190058550A (ko) 2019-05-29

Family

ID=61619769

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197011397A Ceased KR20190058550A (ko) 2016-09-19 2017-09-18 병용 요법

Country Status (13)

Country Link
US (1) US20190201409A1 (enExample)
EP (1) EP3515414B1 (enExample)
JP (2) JP2019529419A (enExample)
KR (1) KR20190058550A (enExample)
CN (1) CN109982687A (enExample)
AU (1) AU2017326558B2 (enExample)
BR (1) BR112019005337A2 (enExample)
CA (1) CA3037364A1 (enExample)
IL (2) IL292938A (enExample)
MA (1) MA46285A (enExample)
MX (1) MX390121B (enExample)
SG (1) SG10202102845XA (enExample)
WO (1) WO2018053437A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62713B1 (sr) * 2014-08-11 2022-01-31 Acerta Pharma Bv Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora
KR20240097982A (ko) 2017-05-23 2024-06-27 메이 파마, 아이엔씨. 병용 요법
MX2020001727A (es) 2017-08-14 2020-03-20 Mei Pharma Inc Terapia de combinacion.
AU2019322858A1 (en) * 2018-08-14 2021-04-01 Mei Pharma, Inc. Combination therapy
US20210299134A1 (en) * 2018-08-14 2021-09-30 Mei Pharma, Inc. Treatment of b cell malignancies
CA3109377A1 (en) * 2018-08-14 2020-02-20 Mei Pharma, Inc. Treatment of relapsed follicular lymphoma
WO2020124136A1 (en) * 2018-12-21 2020-06-25 The Walter And Eliza Hall Institute Of Medical Research Methods of treating inflammation
TW202038945A (zh) * 2018-12-21 2020-11-01 美商梅製藥公司 組合療法
KR20220164788A (ko) * 2020-04-07 2022-12-13 메이 파마, 아이엔씨. 1,3,5-트리아지닐 벤즈이미다졸의 제조
CA3181730A1 (en) * 2020-06-11 2021-12-16 Daniel P. Gold Combination therapies
CN111701026B (zh) * 2020-06-28 2022-10-21 吴燕 抗肿瘤的组合药物纳米载体及其制备方法
CN118949002A (zh) * 2024-10-15 2024-11-15 杭州阿克索生物科技有限责任公司 一种宫颈癌细胞抑制组合物及其制备方法和应用

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