KR20180115346A - 칼슘 통로 차단제로서 ｎ-피페리디닐 아세트아미드 유도체 - Google Patents

칼슘 통로 차단제로서 ｎ-피페리디닐 아세트아미드 유도체 Download PDF

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KR20180115346A
KR20180115346A KR1020187029396A KR20187029396A KR20180115346A KR 20180115346 A KR20180115346 A KR 20180115346A KR 1020187029396 A KR1020187029396 A KR 1020187029396A KR 20187029396 A KR20187029396 A KR 20187029396A KR 20180115346 A KR20180115346 A KR 20180115346A
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carbon atoms
optionally substituted
alkyl
formula
heteroalkyl
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핫산 파조우헤쉬
라메쉬 카울
얀빙 딩
용바오 주
링윈 장
나가스리 차카
마이크 그림우드
제이슨 탄
위안시 조우
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타로 파마슈티컬즈 인코포레이티드
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Publication of KR20180115346A publication Critical patent/KR20180115346A/ko
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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2651811A1 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US20120220603A1 (en) * 2009-09-04 2012-08-30 Zalicus Pharmaceuticals Ltd. Substituted heterocyclic derivatives for the treatment of pain and epilepsy
CA2771612A1 (en) * 2009-09-18 2011-03-24 Zalicus Pharmaceuticals Ltd. Selective calcium channel modulators
US8591944B2 (en) 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
MX351287B (es) * 2012-02-21 2017-10-09 Acraf Compuestos de 1h-indazol-3-carboxamida como inhibidores de glucogeno sintasa quinasa 3 beta.
CN104203928B (zh) 2012-03-30 2017-06-06 日产化学工业株式会社 三嗪酮化合物及t型钙通道阻滞剂
EP2961403A4 (en) 2013-03-01 2016-11-30 Zalicus Pharmaceuticals Ltd HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL
WO2015050212A1 (ja) * 2013-10-02 2015-04-09 日産化学工業株式会社 Ｔ型カルシウムチャネル阻害剤
TW201536761A (zh) 2013-12-17 2015-10-01 Nissan Chemical Ind Ltd 取代三嗪酮化合物及ｔ型鈣通道阻斷劑
FI3364993T3 (fi) 2015-10-22 2023-01-13 Menetelmiä angelmanin oireyhtymän hoitamiseksi
AU2016353446B2 (en) * 2015-11-12 2022-05-19 Afasci, Inc. Ion channel inhibitory compounds, pharmaceutical formulations and uses
US20210128537A1 (en) * 2016-12-21 2021-05-06 Praxis Precision Medicines, Inc. T-type calcium channel modulators and methods of use thereof
CA3053781A1 (en) 2017-02-15 2018-08-23 Cavion, Inc. Benzopyran and naphalene derivatives and their uses as calium channel inhibitors
CA3061720A1 (en) 2017-04-26 2018-11-01 Cavion, Inc. Methods for improving memory and cognition and for treating memory and cognitive disorders
IL270137B2 (en) * 2017-04-26 2024-04-01 Cavion Inc A T-type calcium channel antagonist for the treatment of Derbet's syndrome
JP7480131B2 (ja) 2018-10-03 2024-05-09 カビオン・インコーポレイテッド （ｒ）－２－（４－イソプロピルフェニル）－ｎ－（１－（５－（２，２，２－トリフルオロエトキシ）ピリジン－２－イル）エチル）アセトアミドを使用した本態性振戦の処置
CN114340670A (zh) 2019-07-11 2022-04-12 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法
MX2022013595A (es) * 2020-04-29 2023-01-24 Praxis Prec Medicines Inc Metodos de uso de moduladores del canal de calcio tipo t.
CN116669724A (zh) * 2020-11-09 2023-08-29 普拉西斯精密医药公司 T型钙通道调节剂和其使用方法
JP2023549134A (ja) * 2020-11-09 2023-11-22 プラクシス プレシジョン メディシンズ， インコーポレイテッド Ｔ型カルシウムチャネル調節因子及びその使用方法
TW202308653A (zh) * 2021-04-26 2023-03-01 美商普雷西斯精密藥品股份有限公司 以神經活性類固醇進行治療的方法
CN114518425B (zh) * 2022-02-11 2023-03-10 中国科学技术大学 同时检测单个免疫细胞胞浆和细胞膜的代谢物的分析方法
CA3255733A1 (en) * 2022-04-01 2023-10-05 Praxis Prec Medicines Inc T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND RELATED METHODS OF USE
WO2023192665A2 (en) * 2022-04-01 2023-10-05 Praxis Precision Medicines, Inc. T-type calcium channel modulators and methods of use thereof
CN119584962A (zh) * 2022-05-09 2025-03-07 普拉西斯精密医药公司 T型钙通道调节剂的使用方法
KR20250165616A (ko) * 2023-03-02 2025-11-26 프락시스 프리시젼 메디신즈, 인크. 고함량 단일 투여 단위 제형 및 이의 사용 방법
CN121013719A (zh) * 2023-03-02 2025-11-25 普拉西斯精密医药公司 治疗特发性震颤的方法
WO2025188619A1 (en) * 2024-03-04 2025-09-12 Praxis Precision Medicines, Inc. Methods of treating parkinson's disease with t-type calcium channel modulators

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
JPH11513382A (ja) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
FR2769914B1 (fr) 1997-10-21 2000-02-04 Synthelabo Derives d'indazole tricycliques leur preparation et leur application en therapeutique
US20030125269A1 (en) * 1998-08-26 2003-07-03 Ming Li T-type calcium channel
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
GR20000100283A (el) * 2000-08-17 2002-05-24 Κωνσταντινος Αλεξοπουλος Μη-πεπτιδικοι μιμητες της δραστικης αλληλουχιας s42fllr46 του υποδοχεα της θρομβινης για την θεραπεια της θρομβωσης και του καρκινου
EP1217000A1 (en) * 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
AU2002338334B8 (en) * 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
WO2003007953A1 (en) 2001-07-18 2003-01-30 Washington University Methods and compositions for modulating t-type calcium channels
KR100534556B1 (ko) * 2001-10-26 2005-12-08 주식회사 오리엔트바이오 알파１ｇ 단백질의 기능을 억제하여 간질을 일으키지 않게하는 방법
KR20030037081A (ko) * 2001-11-02 2003-05-12 한국과학기술연구원 Ｔ 타입 칼슘채널을 조절하여 복통을 억제하는 방법
GB0126781D0 (en) * 2001-11-07 2002-01-02 Medical Res Council Modulation
DE10227511A1 (de) 2002-06-19 2004-01-08 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur medikamentösen Behandlung von akuten und chronischen Schmerzen
WO2004035000A2 (en) * 2002-10-17 2004-04-29 Merck & Co., Inc. Enhancement of sleep with t-type calcium channel antagonists
AU2003284402A1 (en) 2002-11-15 2004-06-15 Yamanouchi Pharmaceutical Co., Ltd. Antagonist to melanin-concentrating hormone receptor
EP1583821A4 (en) * 2003-01-15 2007-07-18 Millennium Pharm Inc METHODS AND COMPOSITIONS FOR TREATING UROLOGICAL DISORDERS USING GENES 44390, 54181, 211, 5687, 884, 1405, 636, 4421, 5410, 30905, 2045, 16405, 18560, 2047, 33751, 52872, 14063, 20739, 32544, 43239, 44373, 51164, 53010, 16852, 1587, 2207, 22245, 2387, 52908, 69112, 14990, 18547, 115, 579
EP1633343A1 (en) * 2003-05-30 2006-03-15 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
US7507760B2 (en) * 2004-01-22 2009-03-24 Neuromed Pharmaceuticals Ltd. N-type calcium channel blockers
US20080160009A1 (en) 2004-02-11 2008-07-03 Gray Lloyd S Inhibiting Cav3 Isoforms and the 25B Splice Varients for the Diagnosis and Treatment of Cancer
WO2005092882A1 (en) 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US20060003020A1 (en) 2004-03-11 2006-01-05 The Regents Of The University Of Michigan Anti-metastatic ability of mibefradil and gadolinium
US7888374B2 (en) * 2005-01-28 2011-02-15 Abbott Laboratories Inhibitors of c-jun N-terminal kinases
WO2007002361A2 (en) * 2005-06-23 2007-01-04 Merck & Co., Inc. 3-fluoro-piperidine t-type calcium channel antagonists
CA2611639A1 (en) 2005-06-29 2007-01-04 Merck & Co., Inc. 4-fluoro-piperidine t-type calcium channel antagonists
WO2007053819A2 (en) 2005-10-31 2007-05-10 Bristol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
US8629147B2 (en) * 2005-11-03 2014-01-14 Chembridge Corporation Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
CN101336229B (zh) 2005-12-23 2012-06-13 西兰岛药物有限公司 改性的拟赖氨酸化合物
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
WO2008031227A1 (en) 2006-09-14 2008-03-20 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
US20090298834A1 (en) * 2008-06-02 2009-12-03 Hassan Pajouhesh 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers
CA2771612A1 (en) 2009-09-18 2011-03-24 Zalicus Pharmaceuticals Ltd. Selective calcium channel modulators

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