KR20170102069A - 헌팅틴 발현의 조절 - Google Patents

헌팅틴 발현의 조절 Download PDF

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KR20170102069A
KR20170102069A KR1020177024113A KR20177024113A KR20170102069A KR 20170102069 A KR20170102069 A KR 20170102069A KR 1020177024113 A KR1020177024113 A KR 1020177024113A KR 20177024113 A KR20177024113 A KR 20177024113A KR 20170102069 A KR20170102069 A KR 20170102069A
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South Korea
Prior art keywords
certain embodiments
isis
antisense
huntingtin
target
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Ceased
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KR1020177024113A
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English (en)
Korean (ko)
Inventor
젠 흉
씨. 프랭크 벤네트
수잔 엠 프레이어
홀리 코다세위츠
리사 스탄네크
돈 더블유. 클리브랜드
셍 에이치. 쳉
라먀 쉬하부딘
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아이오니스 파마수티컬즈, 인코포레이티드
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Publication of KR20170102069A publication Critical patent/KR20170102069A/ko
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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KR1020177024113A 2009-09-11 2010-09-10 헌팅틴 발현의 조절 Ceased KR20170102069A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24185309P 2009-09-11 2009-09-11
US61/241,853 2009-09-11
PCT/US2010/048532 WO2011032045A1 (en) 2009-09-11 2010-09-10 Modulation of huntingtin expression

Related Parent Applications (1)

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KR1020127009137A Division KR101774526B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절

Related Child Applications (1)

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KR1020187037590A Division KR102175230B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절

Publications (1)

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KR20170102069A true KR20170102069A (ko) 2017-09-06

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KR1020177024113A Ceased KR20170102069A (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020127009137A Active KR101774526B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020207031044A Active KR102279458B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020187037590A Active KR102175230B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020197026749A Active KR102173836B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절

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KR1020127009137A Active KR101774526B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020207031044A Active KR102279458B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020187037590A Active KR102175230B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절
KR1020197026749A Active KR102173836B1 (ko) 2009-09-11 2010-09-10 헌팅틴 발현의 조절

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Country Link
US (8) US8906873B2 (https=)
EP (3) EP3626823A1 (https=)
JP (5) JP5809146B2 (https=)
KR (5) KR20170102069A (https=)
CN (3) CN111705058A (https=)
AU (4) AU2010292003B2 (https=)
BR (1) BR112012005448B1 (https=)
CA (2) CA2773886C (https=)
DK (1) DK2475675T3 (https=)
ES (2) ES2615534T3 (https=)
HU (1) HUE033113T2 (https=)
IL (4) IL218482A (https=)
MX (3) MX340397B (https=)
NZ (3) NZ714887A (https=)
PL (1) PL2475675T3 (https=)
PT (1) PT2475675T (https=)
RU (2) RU2562861C2 (https=)
SI (1) SI2475675T1 (https=)
WO (1) WO2011032045A1 (https=)

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WO2010014592A1 (en) 2008-07-29 2010-02-04 The Board Of Regents Of The University Of Texas Sytem Selective inhibition of polyglutamine protein expression
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