KR20170086700A - 수지상 세포 조성물 및 방법 - Google Patents

수지상 세포 조성물 및 방법 Download PDF

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KR20170086700A
KR20170086700A KR1020177020072A KR20177020072A KR20170086700A KR 20170086700 A KR20170086700 A KR 20170086700A KR 1020177020072 A KR1020177020072 A KR 1020177020072A KR 20177020072 A KR20177020072 A KR 20177020072A KR 20170086700 A KR20170086700 A KR 20170086700A
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cells
monocytes
dendritic cells
cell
dna
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Korean (ko)
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레베카 포그-칼리
타마라 몬스미쓰
이리나 체레파노바
로이스 딘터만
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아르고스 쎄라퓨틱스 인코포레이티드
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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KR1020177020072A 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법 Ceased KR20170086700A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66946805P 2005-04-08 2005-04-08
US60/669,468 2005-04-08
PCT/US2006/013159 WO2006127150A2 (en) 2005-04-08 2006-04-07 Dendritic cell compositions and methods

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KR1020167009557A Division KR20160045151A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법

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KR20170086700A true KR20170086700A (ko) 2017-07-26

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KR1020177020072A Ceased KR20170086700A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR20157005703A Ceased KR20150032915A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020077025609A Expired - Fee Related KR101368035B1 (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020137010879A Ceased KR20130061753A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020167009557A Ceased KR20160045151A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020207016974A Ceased KR20200072566A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법

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KR20157005703A Ceased KR20150032915A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020077025609A Expired - Fee Related KR101368035B1 (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020137010879A Ceased KR20130061753A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020167009557A Ceased KR20160045151A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법
KR1020207016974A Ceased KR20200072566A (ko) 2005-04-08 2006-04-07 수지상 세포 조성물 및 방법

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US (6) USRE46152E1 (cg-RX-API-DMAC7.html)
EP (1) EP1882031B1 (cg-RX-API-DMAC7.html)
JP (1) JP5020935B2 (cg-RX-API-DMAC7.html)
KR (6) KR20170086700A (cg-RX-API-DMAC7.html)
CN (1) CN101155914B (cg-RX-API-DMAC7.html)
AU (1) AU2006249640C1 (cg-RX-API-DMAC7.html)
CA (1) CA2602434C (cg-RX-API-DMAC7.html)
ES (1) ES2650569T3 (cg-RX-API-DMAC7.html)
IL (2) IL185977A0 (cg-RX-API-DMAC7.html)
MX (1) MX2007012221A (cg-RX-API-DMAC7.html)
NO (1) NO345353B1 (cg-RX-API-DMAC7.html)
WO (1) WO2006127150A2 (cg-RX-API-DMAC7.html)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
WO2007065439A1 (en) * 2005-12-08 2007-06-14 Dandrit Biotech A/S Method for generating dendritic cells employing decreased temperature
AU2007238660C1 (en) 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
US8524495B2 (en) 2007-05-16 2013-09-03 Yale University Methods for inducing the differentiation of blood monocytes into functional dendritic cells
KR100935826B1 (ko) 2007-11-27 2010-01-08 주식회사 바이넥스 부유밀도구배 원심분리를 이용하여 말초혈액단핵구로부터 단세포를 분리하는 방법
US8513208B2 (en) 2008-02-28 2013-08-20 Argos Therapeutics, Inc. Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection
WO2009120891A2 (en) * 2008-03-27 2009-10-01 Geron Corporation Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
AU2009236306B2 (en) 2008-04-17 2015-04-02 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
KR20110081336A (ko) * 2008-11-04 2011-07-13 이데라 파마슈티칼즈, 인코포레이티드 안티센스 올리고누클레오티드에 의한 toll―유사 수용체 2 발현의 조절
WO2011032161A2 (en) 2009-09-14 2011-03-17 Baylor Research Institute Vaccines directed to langerhans cells
BR112012014104A2 (pt) * 2009-12-04 2016-07-05 Stem Cell & Regenerative Medicine International Inc método de geração de células destrutoras naturais e células dendríticas de hemangioblastos embrionários humanos derivados de células-tronco
JP2013522309A (ja) * 2010-03-15 2013-06-13 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 活性化した成熟樹状細胞を調製し保存するシステムおよび方法
DK2552410T3 (en) 2010-03-31 2019-02-18 Stabilitech Biopharma Ltd PROCEDURE FOR THE CONSERVATION OF ALUNADUVANCES AND VACCINES WITH ALUNADUVANCES
JP5869553B2 (ja) 2010-03-31 2016-02-24 スタビリテック リミテッド ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤
WO2011121306A1 (en) 2010-03-31 2011-10-06 Stabilitech Ltd. Stabilisation of viral particles
US20130011438A1 (en) * 2011-07-05 2013-01-10 SOTIO a.s. Means And Methods For Active Cellular Immunotherapy Of Cancer By Using Tumor Cells Killed By High Hydrostatic Pressure and Dendritic Cells
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
PL2785359T3 (pl) 2011-11-30 2018-12-31 Astellas Institute For Regenerative Medicine Mezenchymalne komórki zrębowe i związane z nimi zastosowania
SG11201404570WA (en) * 2012-02-10 2014-11-27 Hakushinkouseikai Foundation Proliferating agent for monocyte, culture medium for proliferating monocyte, method for producing monocyte, method for producing dendritic cell, and method for producing dendritic cell vaccine
EP2857498B1 (en) * 2012-05-31 2018-04-25 JW Creagene Inc. Composition for maturing dendritic cells, and method for preparing antigen-specific dendritic cells using same
US10286064B2 (en) 2012-06-15 2019-05-14 Pds Biotechnology Corporation Cationic lipid vaccine compositions and methods of use
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
AU2013317805B2 (en) 2012-09-21 2018-07-26 Pds Biotechnology Corporation Improved vaccine compositions and methods of use
AU2014213009B2 (en) * 2013-02-01 2019-01-03 Kira Biotech Pty Limited Anti-CD83 antibodies and use thereof
TWI656839B (zh) * 2013-03-15 2019-04-21 健臻公司 高密度細胞儲存方法
ES2777304T3 (es) * 2014-02-21 2020-08-04 Colmmune Inc Células TSCM y métodos de uso
CN103948917A (zh) * 2014-04-02 2014-07-30 江苏和泽生物科技有限公司 树突状细胞疫苗的制备方法
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
GB201413665D0 (en) 2014-07-03 2014-09-17 Transimmune Ag And Yale University Method for obtaining globally activated monocytes
KR101518972B1 (ko) 2014-08-01 2015-05-18 제이더블유크레아젠 주식회사 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도
EP3957173A1 (en) 2014-09-18 2022-02-23 Genzyme Corporation Ultra-high density cell banking methods
WO2016076428A1 (ja) 2014-11-14 2016-05-19 日本赤十字社 臍帯血および末梢血の凍結保存方法および凍結保存用溶液
WO2016179001A1 (en) * 2015-05-01 2016-11-10 Baylor College Of Medicine Methods for enhancing an immune response with a ctla-4 antagonist
CN107921063A (zh) * 2015-07-02 2018-04-17 普莱瓦克斯免疫肿瘤学公司 用于采用登革病毒与树突细胞的联合疗法的组合物及方法
US11612652B2 (en) * 2015-11-13 2023-03-28 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
JP6779616B2 (ja) * 2015-12-25 2020-11-04 富士ソフト株式会社 Nkt細胞活性化医薬組成物、その製造方法、及び抗原提示細胞の保存方法
CN109715196A (zh) 2016-06-13 2019-05-03 转矩医疗股份有限公司 用于促进免疫细胞功能的组合物和方法
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
CA3074826A1 (en) 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
JP2021502419A (ja) * 2017-11-07 2021-01-28 コイミューン インコーポレイテッド 樹状細胞治療のための方法および使用
TW201924722A (zh) 2017-12-05 2019-07-01 美商Pds生技公司 用於刺激第i型干擾素基因之方法及包含陽離子脂質的組合物
WO2019136155A1 (en) * 2018-01-08 2019-07-11 The Regents Of The University Of Michigan Aldh1 antigen-pulsed dendritic cells
WO2019196088A1 (en) 2018-04-13 2019-10-17 Syz Cell Therapy Co. Methods of obtaining tumor-specific t cell receptors
CA3106403A1 (en) 2018-07-15 2020-01-23 Enochian BioPharma, Inc. Methods and compositions using recombinant dendritic cells for cancer therapy
KR102159766B1 (ko) * 2018-11-12 2020-09-24 조선대학교산학협력단 홍조류추출물을 이용한 미성숙수지상세포 분화유도용 배지조성물 및 미성숙수지상세포 분화유도방법
JP2022525928A (ja) * 2019-03-21 2022-05-20 ガミダ セル リミテッド 併用療法における移植に適したnk細胞画分の増殖及び増殖nk細胞画分の使用
CN114621921A (zh) * 2020-12-11 2022-06-14 深圳先进技术研究院 一种提取神经突触体的方法
CN117881794A (zh) * 2021-06-30 2024-04-12 诺瓦瑟拉姆株式会社 制备包含血中循环肿瘤细胞的试样的方法
CN113980901B (zh) * 2021-12-28 2022-06-17 上海惠盾因泰生物科技有限公司 一种制备高纯度的成熟人树突状细胞的方法及应用
EP4544028A4 (en) * 2022-06-24 2026-05-20 Lihpao Life Science Corp PROCESS FOR THE PRODUCTION OF MATURE DENDRITIC CELLS
US12642618B2 (en) * 2023-01-04 2026-06-02 Sheridan O'Neal Carriers for collecting biological samples

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
KR20000022445A (ko) 1996-07-10 2000-04-25 크리스토퍼 엘. 와이트, 스코트 지. 홀퀴스트, 스티븐 엘. 말라스카 수상돌기 세포의 활성화 방법
US20050084966A1 (en) 1999-04-20 2005-04-21 Edelson Richard L. Methods for inducing the differentiation of blood monocytes into functional dendritic cells
WO2000062818A1 (en) 1999-04-20 2000-10-26 Richard Leslie Edelson Differentiation of monocytes into functional dendritic cells
US20050158856A1 (en) 1999-04-20 2005-07-21 Edelson Richard L. Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials
IT1312570B1 (it) * 1999-05-28 2002-04-22 Genera Spa Metodo per il traferimento di antigeni a cellule dendritiche.
DE10041515A1 (de) 2000-08-24 2002-03-14 Gerold Schuler Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen
EP1270732A1 (en) 2001-06-21 2003-01-02 Schuler, Gerold Improved transfection of eukaryontic cells with linear polynucleotides by electroporation
FR2833271B1 (fr) 2001-12-10 2004-09-17 Coletica Production de cellules dendritiques in vitro a partir de monocytes cd14+, pour notamment la realisation de modeles cellulaires et/ou tissulaires en suspension, en monocouches et tridimentionnels; utilisation de ces modeles
JP4567446B2 (ja) 2002-06-19 2010-10-20 ノースウエスト バイオセラピューティクス,インコーポレイティド 白血球富化のための平行流濾過デバイスおよび方法
EP1389480A1 (en) * 2002-08-14 2004-02-18 Mondobiotech Interferon SA Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation
US20060239962A1 (en) 2002-12-04 2006-10-26 Banchereau Jacques F Rapid one-step generation of antigen loaded dendritic cell vaccine from precursors
CN1264974C (zh) * 2003-01-17 2006-07-19 江西医学院 白血病细胞诱导生成树突状细胞的培养基及其培养方法与应用
ATE420946T1 (de) 2003-02-27 2009-01-15 Northwest Biotherapeutics Inc Erzeugung dendritischer zellen aus monozytischen dendritischen vorläuferzellen mit gm-csf ohne anwesenheit zusätzlicher zytokine
CA2577320C (en) 2004-09-14 2019-08-13 Argos Therapeutics, Inc. Strain-independent amplification of pathogens and vaccines thereto
US8513008B2 (en) * 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
DE602005025005D1 (de) 2004-10-07 2011-01-05 Argos Therapeutics Inc Zusammensetzungen reifer dendritischer zellen und verfahren zu deren kultivierung

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