KR20160114184A - 화합물들의 효과적인 생산을 위한 미생물 엔지니어링 - Google Patents

화합물들의 효과적인 생산을 위한 미생물 엔지니어링 Download PDF

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KR20160114184A
KR20160114184A KR1020167025628A KR20167025628A KR20160114184A KR 20160114184 A KR20160114184 A KR 20160114184A KR 1020167025628 A KR1020167025628 A KR 1020167025628A KR 20167025628 A KR20167025628 A KR 20167025628A KR 20160114184 A KR20160114184 A KR 20160114184A
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gene
mutation
strain
coli
production
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Inventor
웨이 공
수단슈 돌
타미 그라바
앤드류 크리스토퍼 콜라드
재니스 지. 페로
알. 로져스 요컴
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미리안트 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/04—Positioning of patients; Tiltable beds or the like
    • A61B6/0407—Supports, e.g. tables or beds, for the body or parts of the body
    • A61B6/0442—Supports, e.g. tables or beds, for the body or parts of the body made of non-metallic materials
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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    • B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
    • B29C70/04—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising reinforcements only, e.g. self-reinforcing plastics
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Composite Materials (AREA)
  • Mechanical Engineering (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020167025628A 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링 Ceased KR20160114184A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28148109P 2009-11-18 2009-11-18
US61/281,481 2009-11-18
PCT/US2010/057119 WO2011063055A2 (en) 2009-11-18 2010-11-17 Engineering microbes for efficient production of chemicals

Related Parent Applications (1)

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KR20127015612A Division KR20120099258A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링

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KR20160114184A true KR20160114184A (ko) 2016-10-04

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KR1020167025628A Ceased KR20160114184A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링
KR20127015612A Ceased KR20120099258A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링

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KR20127015612A Ceased KR20120099258A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링

Country Status (7)

Country Link
US (1) US9017976B2 (enExample)
EP (1) EP2501797A4 (enExample)
JP (1) JP2013511277A (enExample)
KR (2) KR20160114184A (enExample)
CN (1) CN102666838B (enExample)
BR (1) BR112012011990A2 (enExample)
WO (1) WO2011063055A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020075943A1 (ko) * 2018-10-10 2020-04-16 한국과학기술원 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법

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* Cited by examiner, † Cited by third party
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US8871489B2 (en) * 2009-11-18 2014-10-28 Myriant Corporation Metabolic evolution of Escherichia coli strains that produce organic acids
CA2807561C (en) 2010-08-06 2022-04-12 Mascoma Corporation Production of malonyl-coa derived products via anaerobic pathways
CA2862051A1 (en) * 2012-01-30 2013-08-08 Myriant Corporation Production of muconic acid from genetically engineered microorganisms
CN102994436A (zh) * 2012-10-29 2013-03-27 江南大学 一种产减毒类脂a的大肠杆菌基因工程菌及其应用
JP6085190B2 (ja) * 2013-02-26 2017-02-22 花王株式会社 変異微生物及びそれを用いた有用物質の生産方法
KR101594156B1 (ko) 2013-06-25 2016-02-15 씨제이제일제당 주식회사 Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법
ES2908342T3 (es) * 2013-07-23 2022-04-28 Ptt Global Chemical Public Co Ltd Método de producción de ácido succínico utilizando difusión facilitada para la importación de azúcar
CN105705647B (zh) 2013-09-03 2020-03-27 Ptt全球化学公众有限公司 从1，3-丙二醇制造丙烯酸、丙烯腈和1，4-丁二醇的方法
CN104046586B (zh) * 2014-07-02 2016-08-17 山东大学 一株基因工程菌及其在生产(2r,3r)-2,3-丁二醇中的应用
DK3194604T3 (da) * 2014-09-18 2020-05-25 Genomatica Inc Ikke-naturlig mikrobielle organismer med forbedret energisk effektivitet
US10301613B2 (en) 2015-09-15 2019-05-28 Arizona Board Of Regents On Behalf Of Arizona State University Targeted remodeling of prokaryotic genomes using CRISPR-nickases
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PT3448859T (pt) 2017-03-20 2019-10-25 Forma Therapeutics Inc Composições de pirrolopirrole como ativadores de piruvato quinase (pkr).
CA3068459A1 (en) 2017-06-30 2019-01-03 Ptt Global Chemical Public Company Limited Microorganism with stabilized copy number of functional dna sequence and associated methods
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
ES2989438T3 (es) 2018-09-19 2024-11-26 Novo Nordisk Healthcare Ag Activación de la piruvato cinasa R
CN109251941B (zh) * 2018-09-30 2020-11-06 江南大学 一种高产琥珀酸的大肠杆菌及其应用
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CN113278641B (zh) * 2020-05-27 2022-06-21 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组大肠杆菌、其构建方法及其应用
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Citations (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455284B1 (en) 1998-04-13 2002-09-24 The University Of Georgia Research Foundation, Inc. Metabolically engineered E. coli for enhanced production of oxaloacetate-derived biochemicals
US20040146966A1 (en) 2002-12-19 2004-07-29 Qiong Cheng Mutations affecting carotenoid production
US20040214294A1 (en) 2003-04-01 2004-10-28 Mechthild Rieping Process for the production of L-amino acids using strains of the enterobacteriaceae family
US20050176114A1 (en) 2004-02-05 2005-08-11 Cj Corporation Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism
US20050181488A1 (en) 2004-02-12 2005-08-18 Akhverdian Valery Z. Method for producing L-threonine using bacteria belonging to the genus Escherichia
US20050221455A1 (en) 2003-10-21 2005-10-06 Cargill, Inc. Production of monatin and monatin precursors
US6962794B2 (en) 1995-05-05 2005-11-08 Genecor International, Inc. Application of glucose transport mutants for production of aromatic pathway compounds
US6989265B2 (en) 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome
US20060073577A1 (en) 2004-09-17 2006-04-06 San Ka-Yiu High succinate producing bacteria
US20070111294A1 (en) 2005-09-09 2007-05-17 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US7223567B2 (en) 2004-08-27 2007-05-29 Rice University Mutant E. coli strain with increased succinic acid production
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
US20080009041A1 (en) 2004-11-26 2008-01-10 Hiroshi Mizoguchi Industrially Useful Microorganism
US7371558B2 (en) 2002-10-04 2008-05-13 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
WO2008115958A2 (en) 2007-03-20 2008-09-25 University Of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
US20080293100A1 (en) 2005-10-05 2008-11-27 Degussa Gmbh Method for the Fermentative Production of L-Amino Acids With the Aid of Coryneform Bacteria Capable of Using Glycerin as the Only Carbon Source
US20090047719A1 (en) 2007-08-10 2009-02-19 Burgard Anthony P Methods and organisms for the growth-coupled production of 1,4-butanediol
US20090075352A1 (en) 2005-04-08 2009-03-19 Korea Advanced Institute Of Science And Technology Method For Improving A Strain Based On In-Silico Analysis
US20090075333A1 (en) 2005-08-20 2009-03-19 Campbell John W Reduced Genome E. Coli
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
US20090221055A1 (en) 2005-10-13 2009-09-03 Kao Corporation; And Nara Institute Of Science And Technology Novel Bacillus Subtilis Mutant Strain
US7629162B2 (en) 2005-08-10 2009-12-08 University Of Florida Research Foundation, Inc. Materials and methods for efficient lactic acid production
US20090325243A1 (en) 2006-06-26 2009-12-31 Young Hoon Park Method for producing amino acids using glycerol
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
US20100248311A1 (en) 2007-10-02 2010-09-30 Metabolic Explorer Increasing methionine yield
WO2010115067A2 (en) 2009-04-02 2010-10-07 University Of Florida Research Foundation, Inc. Engineering the pathway for succinate production
US20100261239A1 (en) 2007-03-23 2010-10-14 Metalbolic Explorer Metabolically engineered microorganism useful for the production of 1,2-propanediol
EP2241630A1 (en) 2007-12-06 2010-10-20 Ajinomoto Co., Inc. Process for production of organic acid
US20100279369A1 (en) 2007-03-23 2010-11-04 Metabolic Explorer Metabolically engineered microorganism useful for the production of acetol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101390085B1 (ko) * 2006-03-31 2014-04-28 라이스 유니버시티 글리세롤의 혐기성 발효
EP2158323A4 (en) * 2007-05-18 2011-06-22 Microbia Prec Engineering Inc PRODUCTION OF ORGANIC ACID BY PILZ CELLS
US20100330614A1 (en) * 2007-11-06 2010-12-30 Massachusetts Institute Of Technology Global transcription machinery engineering targeting the rnap alpha subunit (rpoa)

Patent Citations (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962794B2 (en) 1995-05-05 2005-11-08 Genecor International, Inc. Application of glucose transport mutants for production of aromatic pathway compounds
US6455284B1 (en) 1998-04-13 2002-09-24 The University Of Georgia Research Foundation, Inc. Metabolically engineered E. coli for enhanced production of oxaloacetate-derived biochemicals
US6989265B2 (en) 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
US7371558B2 (en) 2002-10-04 2008-05-13 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
US20080176302A1 (en) 2002-10-04 2008-07-24 E.I. Dupont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
US20040146966A1 (en) 2002-12-19 2004-07-29 Qiong Cheng Mutations affecting carotenoid production
US20040214294A1 (en) 2003-04-01 2004-10-28 Mechthild Rieping Process for the production of L-amino acids using strains of the enterobacteriaceae family
US20050221455A1 (en) 2003-10-21 2005-10-06 Cargill, Inc. Production of monatin and monatin precursors
US20050176114A1 (en) 2004-02-05 2005-08-11 Cj Corporation Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism
US7229794B2 (en) 2004-02-05 2007-06-12 Cj Corporation Microorganism producing L-threonine having inactivated galR gene, method of producing the same and method of producing L-threonine using the microorganism
US20050181488A1 (en) 2004-02-12 2005-08-18 Akhverdian Valery Z. Method for producing L-threonine using bacteria belonging to the genus Escherichia
US7223567B2 (en) 2004-08-27 2007-05-29 Rice University Mutant E. coli strain with increased succinic acid production
US20060073577A1 (en) 2004-09-17 2006-04-06 San Ka-Yiu High succinate producing bacteria
US20080009041A1 (en) 2004-11-26 2008-01-10 Hiroshi Mizoguchi Industrially Useful Microorganism
US20090075352A1 (en) 2005-04-08 2009-03-19 Korea Advanced Institute Of Science And Technology Method For Improving A Strain Based On In-Silico Analysis
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
US7629162B2 (en) 2005-08-10 2009-12-08 University Of Florida Research Foundation, Inc. Materials and methods for efficient lactic acid production
US20090075333A1 (en) 2005-08-20 2009-03-19 Campbell John W Reduced Genome E. Coli
US20070111294A1 (en) 2005-09-09 2007-05-17 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US20080293100A1 (en) 2005-10-05 2008-11-27 Degussa Gmbh Method for the Fermentative Production of L-Amino Acids With the Aid of Coryneform Bacteria Capable of Using Glycerin as the Only Carbon Source
US20090221055A1 (en) 2005-10-13 2009-09-03 Kao Corporation; And Nara Institute Of Science And Technology Novel Bacillus Subtilis Mutant Strain
US20090325243A1 (en) 2006-06-26 2009-12-31 Young Hoon Park Method for producing amino acids using glycerol
WO2008115958A2 (en) 2007-03-20 2008-09-25 University Of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
US20100261239A1 (en) 2007-03-23 2010-10-14 Metalbolic Explorer Metabolically engineered microorganism useful for the production of 1,2-propanediol
US20100279369A1 (en) 2007-03-23 2010-11-04 Metabolic Explorer Metabolically engineered microorganism useful for the production of acetol
US20090047719A1 (en) 2007-08-10 2009-02-19 Burgard Anthony P Methods and organisms for the growth-coupled production of 1,4-butanediol
US20100248311A1 (en) 2007-10-02 2010-09-30 Metabolic Explorer Increasing methionine yield
EP2241630A1 (en) 2007-12-06 2010-10-20 Ajinomoto Co., Inc. Process for production of organic acid
US20100143997A1 (en) 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
WO2010115067A2 (en) 2009-04-02 2010-10-07 University Of Florida Research Foundation, Inc. Engineering the pathway for succinate production

Non-Patent Citations (37)

* Cited by examiner, † Cited by third party
Title
다첸코, K.A.(Datsenko, K. A.), 워너, B.L.(Wanner, B. L.) (2000) "PCR 생성물들을 사용하는 에셰리키아 콜리 K-12 내에서의 염색체 유전자들의 단일-단계 비활성화(One-step inactivation of chromosomal genes in Escherichia coli K-12 u sing PCR products)." Proc Natl Acad Sci USA 97: 6640- 6645.
루, S.(Lu, S.), 아이트남, M.A.(Eiteman, M. A.), 알트만, E.(Altman, E.) (2009) "듀얼-상 에셰리키아 콜리 발효 내에서의 숙신산염 생산에 영향을 미치는 pH 및 염기 카운터이온(pH and base counterion affect succinate production in dual-phase Escherichia coli fermentations)." J Ind Microbiol Biotechnol 36: 1101-1109.
리, S.J.(Lee, S.J.), 리 D-Y.,(Lee, D-Y.), 킴, T. Y.(Kim, T. Y.), 킴, B.H.(Kim, B.H., Lee J.), 리, S. Y.(Lee, S. Y.) (2005) "게놈 비교을 바탕으로 하는 및 실리코 유전자 노크아웃 시뮬레이션 내에서의, 향상된 숙신산 생산을 위한 에셰리키아 콜리의 대사적 엔지니어링(Metabolilc Engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout stimulation)." App Environ Microbiol 71 : 7880-7887.
리, S.Y.( Lee, S. Y.), 리 D.Y.(Lee, D. Y.), 킴, T.Y.(Kim, T. Y.) (2005) "스트레인 향상을 위한 시스템 바이오테크놀로지(Systems biotechnology for strain improvement)." Trends Biotech 23: 349-358.
리, S.Y.(Lee, S. Y.), 킴, J.M.(Kim, J. M.), 리 J.W.(Lee, J. W.), 킴, T.Y.(Kim, T. Y.), 양, Y.S.(Jang, Y.S.) (2008) "만하이미아 숙시니프로듀슨스에 의한 숙신산 생산을 위한 집적된 바이오 프로세스에 대한 게놈 서열로부터(From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniproducens)." App Microbiol Biotechnol 79: 11-22;
마티네즈, A.(Martinez, A.), 그라바, T.B.(Grabar, T.B.), 샨무감, K.T.(Shanmugam, K.T.), 요마노, L.P.(Yomano, L.P.), 요크, S.W.(York, S.W.), 인그람, L.O.(Ingram, L.O.) (2007) "재조합 에셰리키아 콜리에 의한 락테이트 및 에탄올 생산을 위한 낮은 염 배지(Low salt medium for lactate and ethanol production by recombinant Escherichia coli)." Biotechnol Lett 29:397-404.
밀라드, C.S.(Millard, C. S.), 챠오, Y-P.(Chao, Y-P.), 리아오, J.C.(Liao, J. C.), 도넬리, M.I.(Donnelly, M. I.) (1996) "에셰리키아 콜리 내에서의 포스포에놀 피루베이트 카복실라제의 과발현에 의한 숙신산의 향상된 생산 (Enhanced production of succinic acid by overexpression of phosphoenolpyruvate carboxyalse in Escherichia coli)" App Environ Microbiol 62: 1808-1810.
바바, T.(Baba, T.), 아라 T.(Ara, T.), 하세가와, M(Hasegawa, M.), 타카이, Y.(Takai, Y.), 오쿠무라, Y.(Okumura, Y.), 바바, M.(Baba, M.), 다체코, K.A.(Datseko, K.A.), 토미타, M.(Tomita, M.), 워너, B.L.(Wanner, B. L.), 모리, H.(Mori, H.) (2006) "프레임, 단일-유전자 노크아웃 돌연변이체 내에서의 에셰리키아 콜리 K-12의 건조: 케이오 컬렉션(Construction of Escherichia coli K-12 in- frame, single-gene knockout mutants: the Keio collection)." Mol Syst Biol 2: 아티클 넘버: 2006.0008
바비츠케, P.( Babitzke, P.), 로메오, T.(Romeo, T.) (2007) "CsrB sRNA 과 (family); RNA-결합 조절 단백질들의 서열화(sequestration of RNA-binding regulatory proteins)." Curr Opin Microbiol 10: 156-163.
베무리, G.N.(Vemuri, G. N.), 아이트남, M.A.(Eiteman, M. A.), 알트만, E. (Altman, E.) (2002) "에셰리키아 콜리의 대사적으로 조작된 스트레인들에 의한 숙신산 생산에 대한 성장 모드 및 피루베이트 카복실라제의 효과들(Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli)." App Environ Microbiol 68: 1715-1727.
사이어, M.H.Jr.(Saier, M. H. Jr.), 및 람사이어, T.M.(Ramseier, T. M.)(1996) "엔테릭 박테리아의 분해 대사질 억제자/활성자 (Cra) 단백질(The catabolite repressor/activator (Cra) protein of enteric bacteria)." J Bacteriol 178: 3411-3417.
산체스 AM(Sanchez AM), 버네트 GN(Bennett GN), 산 KY(San KY) (2005) "숙신산염 수율 및 생산성을 향상시키기 위한 에셰리키아 콜리 내에서의 혐기성 중심 대사적 경로의 새로운 경로 엔지니어링 디자인(Novel pathway engineering design of the anaerobic central metabolic pathway in Escherichia coli to increase succinate yield and productivity)." Metab Eng 7:229-239.
수베디, K.P.(Subedi, K. P.), 킴, I.(Kim, I.), 킴, J.(Kim, J.), 민 B.(Min, B.), 박, C(Park, C.) (2007) "에셰리키아 콜리 K12의 디하이드록시아세톤 및 메틸글리옥살 대사에서의 gldA의 역할(Role of gldA in dihydroxyacetone and methylglyoxal metabolism of Escherichia coli K12). FEMS Microbiol Lett 279: 180-187.
수즈키, K(Suzuki, K.), 왕, X.(Wang, X.), 웨일바커, T.(Weilbacher, T.), 퍼네스티그, A.K.(Pernestig, A. K.), 멜레포스, O.(Melefors, O.), 조질리스, D. (Georgellis, D.), 바비츠케, P.(Babitzke, P.), 로메오, T.(Romeo, T). (2002) "에셰리키아 콜리의 CsrA/CsrB 및 BarA/UvrY 시스템의 조절적 회로(Regulatory circuitary of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli)." J Bacteriol 184:5130-5140.
시바가미선다람, C.(Sivagamisundaram, C,) 우프, E.(Wooff, E.), 콜드함, N.G.(Coldham, N. G.), 스리타란, M(Sritharan, M.), 휴인슨, R.G.(Hewinson, R. G.), 고돈, S.V.(Gordon, S. V.), 휠러, P.R.(Wheeler, P. R.) (2009) "마이코박테이움 튜버큘로시스 복합체 내에서의 피루베이트 키나제의 비활성화의 전체적 효과들(Global effects of inactivation of the pyruvate kinase gene in the Mycobacterium tuberculosis complex)." J Bacteteriol 191 :7545-7553.
시볼드, C.(Siebold, C), 가르시아-알레스, L.F.(Garcia-Alles, L. F.), 에르니, B.(Erni, B.), 바우만, U.(Baumann, U.) (2003) "에셰리키아 콜리 하이드록시아세톤 키나제의 서브유닛 K의 x-레이 구조 내에서 결합하는 공유 기질의 메카니즘(A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase)." Proc Natl Aca Sci USA 100:8188-8192.
실하비, T.(Silhavy, T.), 버만, M.(Berman, M.), 엔퀴스트, L.(Enquist, L.) (1984) "유전자 융합으로의 실험(Experiments With Gene Fusions)." 콜드 스프링 하버 레버러토리 프레스, 콜드 스프링 하버, NY(Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY), pp 107-112
알트라스, N.E.(Altaras, N. E.), 카메론 D.C.(Cameron, D. C.) (1999) "에셰리키아 콜리 내에서의 1,2-프로판디올 경로의 대사적 엔지니어링(Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli.)" App Environ Microbiol 65 : 1180-1185.
앤더슨, C(Andersson, C), 호지, D(Hodge, D.), 버글런드, K.A.(Berglund, K.A.), 로바, U.(Rova, U.) (2007) "대사적으로 조작된 에셰리키아 콜리를 사용하는 숙신산의 생산에 대한 다른 탄소원의 효과(Effect of different carbon sources on the production of succinic acid using metabolically engineered Escherichia coli.)" Biotechnol Prog 23: 381-388.
와이커트, M.J.(Weickert, M. J.), 아드히라, S.(Adhya, S.) (1993) "에셰리키아 콜리 내에서의 Gal 억제자 및 동위 억제 유전자들의 전사에 대한 컨트롤 (Control of transcription of Gal Repressor and isorepressor genes in Escherichia coli)." J Bacteriol 175: 251-258.
왕, Q.(Wang, Q.), 첸 X.(Chen, X.), 양, Y.(Yang, Y.), 자오, X.(Zhao, X.) (2006) 실리코 도움의 대사적 분석에서의 게놈-스케일 및 숙신산염 생산을 향상시키기 위한 에셰리키아 콜리의 유동 비교(Genome-scale in silico aided metabolic analysis and flux comparisons of Escherichia coli to improve succinate production)." App Microbiol Biotechnol 2006 73: 887-894.
이케다, M.(Ikeda, M.), 오니쉬, J.(Ohnishi, J.), 하야시, M.(Hayashi, M.), 미츠하시, S.(Mitsuhashi, S). (2006) "효과적인 L-라이신 생산을 위한 최소한으로 돌연변이화된 코리네박테리움 글루타미쿰 스트레인을 형성하는 게놈-바탕의 접근(A genome-based approach to create a minimally mutated Coryebacterium glutamicum strain for efficient L-lysine production)." J Ind Microbiol Biotechnol 33: 610-615
잔타마, K.(Jantama, K.), 장, X.(Zhang, X.), 무어 J.C.(Moore, J. C), 샨무감, K.T.(Shanmugam, K. T.), 스보로노스, S.A.(Svoronos, S. A.), 인그람, L.O.(Ingram, L. O.) (2008b) "에셰리키아 콜리 C의 조작된 스트레인들 내에서 부산물을 제거하는 것 및 숙신산염 수율을 향상시키는 것(Eliminating side products and increasing succinate yields iin engineered strains of Escherichia coli C)." Biotechnol Bioeng 101 : 881-893.
잔타마, K.(Jantama, K.), 합트, M. J.(Haupt, M. J.), 스보로노스, S.A.(Svoronos, S. A.), 장, X.(Zhang, X.), 무어 J.C.(Moore, J. C), 샨무감, K.T.(Shanmugham, K. T.), 인그람, L. O.(Ingram, L. O.) (2008a) "숙신산염 및 말산염을 생산하는 에셰리키아 콜리 C의 비재조합 스트레인들을 개발하기 위한 대사적 엔지니어링 및 대사적 진화의 조합(Combining metabolic engineering and metabolic evolutions to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate)." Biotechnol Bioeng 99: 1140-1153.
장, X(Zhang, X.), 잔타마, K.(Jantama, K.), 무어, J.C.(Moore, J. C), 자르보, L.R.(Jarboe, L. R.), 샨무감, K. T.((Shanmugam, K. T.), 인그람, L.O.(Ingram, L. O.) (2009a) "에셰리키아 콜리 내에서의 숙신산염 생산에 대한 에너지-보존적 경로들의 대사적 진화(Metaboli evolution of energy-conserving pathways for succinate production in Escherichia coli)." Proc Natl Acad Sci USA 106: 20180-20185.
장, X.(Zhang , X.), 잔타마, K.(Jantama, K.), 샨무감, K.T.(Shanmugam, K. T.), 인그람, L.O.(Ingram, L. O.) (2009b) "미네랄 염 배지 내에서의 숙신산염 생산에 대한 에셰리키아 콜리 리엔지니어링(Re-engineering Escherichia coli for succinate production in mineral salts medium)." App Environ Microbiol 75: 7807-7813.
커츠락, T.(Kurzrock, T.), 웨스터-보츠, D.(Weuster-Botz, D.) (2009) "발효 배지로부터의 숙신산의 회수(Recovery of succinic acid from fermentation broth)." Biotechnol Lett 32: 331-339.
코지, T.B.(Causey, T.B.), 샨무감, K.T.(Shanmugam, K.T.), 요마노, L.P.(Yomano, L.P), 인그람, L.O.(Ingram, L.O.) (2004) "글루코오스의 피루브산염으로의 효과적인 전환을 위한 에셰리키아 콜리의 엔지니어링 (Engineering Escherichia coli for efficient conversion of glucose to pyruvate)." Proc Natl Acad Sci USA 101 :2235-2240.
콜리스니첸코, V.(Kolisnychenko, V.), 플런케트 III, G.(Plunkett III, G.), 헤르리그니, C.D.(Herrigni, C. D.), 페허, T.(Feher, T.), 포스파이, J.(Posfai, J.), 블라트너, F. R.(Blattner, F. R.), 포스파이, G.(Posfai, G.) (2009) "감소된 에셰리키아 콜리 게놈의 엔지니어링(Engineering a reduced Escherichia coli genome)." Genome Res 12: 640-647.
크나그, Y.(Knag, Y.), 더핌, T.(Durfeem T.), 그라스너, J.D.(Glasner, J.D.), 퀴, Y.(Qiu, Y.), 프리쉬, D.(Frisch, D.), 윈터버그, K. M.(Winterberg, K. M.), 블라트너, F.R.(Blattner, F. R.) (2004) "에셰리키아 콜리 게놈의 시스템적인 돌연변이 유발(Systematic mutagenesis of the Escherichia coli genome)." J Bacteriol 186: 4921-4930.
크로난, J.(Cronan, J.), 라포르테, D.(Laporte, D.) (1996) "트리카르복실산 회로 및 글리옥살산염 바이패스(Tricarboxylic acid cycle and glyoxylate bypass)" 에셰리키아 콜리 및 살모넬라 내에서의(in Escherichia Coli and Salmonella)." 편집자들 나이트라트, F. 외.(editors Neidhardt, F., et al), ASM Press, 워싱톤 D.C, 미국(Washington, DC, USA).
트루니거, V.(Truniger, V.), 부스, W.(Boos, W.) (1994) "에셰리키아 콜리의 글리세롤 디하이드로게나제의 구조적 유전자, gldA의 맵핑 및 클로닝(Mapping and cloning of gldA, the structural gene of the Escherichia coli glycerol dehydrogenase." J Bacteriol 176: 1796-1800.
퍼네스티그, A.K.(Pernestig, A. K.), 게오게릴스, D.(Geogellis, D.), 로메오, T.(Romeo, T.), 스즈키, K.(Suzuki, K.), 토메니우스, FL.(Tomenius, FL), 노르막, S.(Normakr, S.), 멜레포스, O.(Melefors, O.) (2003) "에셰리키아 콜리 BarA-UvrY 두 성분 시스템은 당분해 및 당신생 탄소원들 사이에서의 효과적인 변환을 위해 요구된다(The Escherichia coli BarA-UvrY two component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources)." J Bacteriol 185:843-853.
포스파이, G.(Posfai, G.), 플런켓 III, G.(Plunket III, G.), 페허, T. (Feher, T.), 프리쉬, D.(Frisch, D.), 케일, G.M.(Keil, G. M.), 우멘노퍼, K (Umenhoffer, K.), 콜리스니첸코, V.(Kolisnychenko, V.), 스탈, B.(Stahl, B.), 샤마, S.(Sharma, S.), 드 스루다, M.(de Srruda, M.), 버란드, V.(Burland, V.), 하쿰, S.W.(Harcum, S. W.), 블라트너, F. R.(Blattner, F. R.) (2006) "감소된-게놈 에셰리키아 콜리의 신생 특성들(Emergent properties of reduced-genome Escherichia coli.)" Science 312: 1044-1046.
폰스, E.(Ponce , E.), 플로레스, N.(Flores, N.), 마티네츠, A.(Martinez, A.), 발레, F.(Valle, F.), 볼리바, F.(Bolivar, F.) (1995) "에셰리키아 콜리로부터의 두 개의 피루베이트 키나제 동위 효소들 구조적 유전자들의 클로닝: 피루브산염 생합성에서의 이들 효소들의 관련성 있는 역할들( Cloning of the two pyruvate kinase isoenzymes structural genes from Escherichia coli: the relative roles of these enzymes in pyruvate biosynthesis)." J Bacteriol 111: 5719-5722.
프리취, P.S.(Fritsch, P. S.), 어바노우스키, M.L.(Urbanowski, M. L.), 스타우퍼, G.V.(Stauffer, G. V.) (2000) "metE 및 metH의 MetR-의존성 활성화에서의 RNA 폴리머라제의 역할: RNA 폴리머라제 내부에서의 C-터미널 도메인 및 방향성에서의 중요한 잔기들(Role of RNA polymerase a subunits in MetR-dependent activation of metE and metH: Important residues in the C-terminal domain and orientation requirements within RNA polymerase)." J Bacteriol 182:5539-5550.
홀크로프트, C.C.(Holcroft, C.C.), 이간, S. M.(Egan, S. M.) (2000) "회로적 AMP 수용체 단백질, RNA 폴리머라제 알파 서브유닛 C-터미널 도메인, 및 RhaR에 의한 rhaSR에서의 활성화의 상호 의존성(Interdependence of activation at rhaSR by cyclic AMP receptor protein, the RNA polymerase alpha subunit C-terminal domain, and RhaR)." J Bacteriol 182: 3529-3535.

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CN102666838A (zh) 2012-09-12
CN102666838B (zh) 2018-04-10
KR20120099258A (ko) 2012-09-07
BR112012011990A2 (pt) 2015-09-29
EP2501797A4 (en) 2013-04-17
EP2501797A2 (en) 2012-09-26
JP2013511277A (ja) 2013-04-04
US9017976B2 (en) 2015-04-28
US20120220000A1 (en) 2012-08-30
WO2011063055A3 (en) 2011-11-17

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