BR112012011990A2 - microrganismo que não ocorre naturalmente e método para produzir ácido succínico - Google Patents
microrganismo que não ocorre naturalmente e método para produzir ácido succínicoInfo
- Publication number
- BR112012011990A2 BR112012011990A2 BR112012011990A BR112012011990A BR112012011990A2 BR 112012011990 A2 BR112012011990 A2 BR 112012011990A2 BR 112012011990 A BR112012011990 A BR 112012011990A BR 112012011990 A BR112012011990 A BR 112012011990A BR 112012011990 A2 BR112012011990 A2 BR 112012011990A2
- Authority
- BR
- Brazil
- Prior art keywords
- production
- succinic acid
- mutations
- chemicals
- metabolic evolution
- Prior art date
Links
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 12
- 238000004519 manufacturing process Methods 0.000 title abstract 9
- 244000005700 microbiome Species 0.000 title abstract 5
- 239000001384 succinic acid Substances 0.000 title abstract 5
- 230000035772 mutation Effects 0.000 abstract 8
- 230000002503 metabolic effect Effects 0.000 abstract 6
- 239000000126 substance Substances 0.000 abstract 6
- 230000001580 bacterial effect Effects 0.000 abstract 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 2
- 238000012824 chemical production Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 235000005985 organic acids Nutrition 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/04—Positioning of patients; Tiltable beds or the like
- A61B6/0407—Supports, e.g. tables or beds, for the body or parts of the body
- A61B6/0442—Supports, e.g. tables or beds, for the body or parts of the body made of non-metallic materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C70/00—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts
- B29C70/04—Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising reinforcements only, e.g. self-reinforcing plastics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mechanical Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Composite Materials (AREA)
- Radiology & Medical Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28148109P | 2009-11-18 | 2009-11-18 | |
| PCT/US2010/057119 WO2011063055A2 (en) | 2009-11-18 | 2010-11-17 | Engineering microbes for efficient production of chemicals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012011990A2 true BR112012011990A2 (pt) | 2015-09-29 |
Family
ID=44060323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012011990A BR112012011990A2 (pt) | 2009-11-18 | 2010-11-17 | microrganismo que não ocorre naturalmente e método para produzir ácido succínico |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9017976B2 (enExample) |
| EP (1) | EP2501797A4 (enExample) |
| JP (1) | JP2013511277A (enExample) |
| KR (2) | KR20120099258A (enExample) |
| CN (1) | CN102666838B (enExample) |
| BR (1) | BR112012011990A2 (enExample) |
| WO (1) | WO2011063055A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120103645A (ko) * | 2009-11-18 | 2012-09-19 | 미리안트 코포레이션 | 유기산들을 생산하는 대장균의 대사적 진화 |
| WO2012019175A2 (en) | 2010-08-06 | 2012-02-09 | Mascoma Corporation | Production of malonyl-coa drived products via anaerobic pathways |
| JP2015504688A (ja) * | 2012-01-30 | 2015-02-16 | ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ | 遺伝子操作された微生物からのムコン酸の生成 |
| CN102994436A (zh) * | 2012-10-29 | 2013-03-27 | 江南大学 | 一种产减毒类脂a的大肠杆菌基因工程菌及其应用 |
| JP6085190B2 (ja) * | 2013-02-26 | 2017-02-22 | 花王株式会社 | 変異微生物及びそれを用いた有用物質の生産方法 |
| KR101594156B1 (ko) | 2013-06-25 | 2016-02-15 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법 |
| CN105452445B (zh) * | 2013-07-23 | 2020-08-21 | Ptt全球化学公众有限公司 | 利用用于糖输入的易化扩散生产琥珀酸和其它化学品的方法 |
| EP3041942B1 (en) | 2013-09-03 | 2020-07-01 | PTT Global Chemical Public Company Limited | A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol |
| CN104046586B (zh) * | 2014-07-02 | 2016-08-17 | 山东大学 | 一株基因工程菌及其在生产(2r,3r)-2,3-丁二醇中的应用 |
| CN107208118A (zh) * | 2014-09-18 | 2017-09-26 | 基因组股份公司 | 具有提高的能源效率的非天然微生物 |
| US10301613B2 (en) | 2015-09-15 | 2019-05-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Targeted remodeling of prokaryotic genomes using CRISPR-nickases |
| EP3423563B1 (en) | 2016-03-02 | 2023-05-24 | PTT Global Chemical Public Company Limited | Improved muconic acid production from genetically engineered microorganisms |
| MD3448859T2 (ro) | 2017-03-20 | 2020-03-31 | Forma Therapeutics Inc | Compoziții de pirolopirol în calitate de activatori ai piruvatkinazei (PKR) |
| KR102683624B1 (ko) | 2017-06-30 | 2024-07-11 | 피티티 글로벌 케미칼 피씨엘 | 기능적 dna 서열의 안정화된 카피 수를 갖는 미생물 및 관련 방법 |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| CN109251941B (zh) * | 2018-09-30 | 2020-11-06 | 江南大学 | 一种高产琥珀酸的大肠杆菌及其应用 |
| KR102129379B1 (ko) * | 2018-10-10 | 2020-07-02 | 한국과학기술원 | 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| AU2020350763A1 (en) | 2019-09-19 | 2022-04-07 | Novo Nordisk Health Care Ag | Pyruvate kinase R (PKR) activating compositions |
| CN113278641B (zh) * | 2020-05-27 | 2022-06-21 | 安徽华恒生物科技股份有限公司 | 生产l-缬氨酸的重组大肠杆菌、其构建方法及其应用 |
| IT202000013243A1 (it) | 2020-06-04 | 2021-12-04 | Novamont Spa | Processo per la purificazione di una miscela di dioli |
| IT202000031979A1 (it) | 2020-12-22 | 2022-06-22 | Novamont Spa | Processo di purificazione di una miscela comprendente dioli e acetali |
| IT202100006419A1 (it) | 2021-03-17 | 2022-09-17 | Novamont Spa | Recupero di dioli da una miscela |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| IT202100030572A1 (it) | 2021-12-02 | 2023-06-02 | Novamont Spa | 1,3-butandiolo purificato da una miscela di dioli |
| CN118546852B (zh) * | 2024-07-30 | 2024-10-18 | 北京化工大学 | 一种高效共利用葡萄糖、木糖生产丁二酸的基因工程菌及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1947186B1 (en) | 1995-05-05 | 2011-11-16 | Danisco US Inc. | Application of glucose transport mutants for production of aromatic pathway compounds |
| MY121380A (en) | 1998-04-13 | 2006-01-28 | Univ Georgia | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6989265B2 (en) | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
| US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
| KR101148255B1 (ko) | 2002-10-04 | 2012-08-08 | 다니스코 유에스 인크. | 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법 |
| US7232665B2 (en) | 2002-12-19 | 2007-06-19 | E. I. Du Pont De Nemours And Company | Mutations affecting carotenoid production |
| DE10314618A1 (de) | 2003-04-01 | 2004-10-14 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| CN103555782B (zh) | 2003-10-21 | 2017-04-12 | 嘉吉有限公司 | 生产莫纳甜和莫纳甜前体 |
| KR100576342B1 (ko) | 2004-02-05 | 2006-05-03 | 씨제이 주식회사 | ｇａｌＲ 유전자가 불활성화된 Ｌ-쓰레오닌 생성 미생물,그를 제조하는 방법 및 상기 미생물을 이용한Ｌ-쓰레오닌의 제조방법 |
| US20050181488A1 (en) | 2004-02-12 | 2005-08-18 | Akhverdian Valery Z. | Method for producing L-threonine using bacteria belonging to the genus Escherichia |
| KR101245428B1 (ko) | 2004-08-27 | 2013-03-19 | 라이스 유니버시티 | 숙신산 생산이 증가된 돌연변이 대장균 균주 |
| US20060073577A1 (en) | 2004-09-17 | 2006-04-06 | San Ka-Yiu | High succinate producing bacteria |
| US20080009041A1 (en) | 2004-11-26 | 2008-01-10 | Hiroshi Mizoguchi | Industrially Useful Microorganism |
| KR100630836B1 (ko) | 2005-04-08 | 2006-10-02 | 한국과학기술원 | 인-실리코 분석을 통한 균주 개량방법 |
| US7524660B2 (en) | 2005-05-05 | 2009-04-28 | E.I. Du Pont De Nemours And Company | Utilization of fructose in microbial production strains |
| EP2305826B1 (en) | 2005-08-10 | 2016-03-30 | University of Florida Research Foundation, Inc. | Materials and methods for efficient lactic acid production |
| US8178339B2 (en) | 2005-08-20 | 2012-05-15 | Scarab Genomics Llc | Reduced genome E. coli |
| EP1937821A4 (en) | 2005-09-09 | 2009-11-11 | Genomatica Inc | PROCESS AND ORGANISMS FOR GROWTH-COUPLED PRODUCTION OF SUCCINATE |
| DE102005047596A1 (de) | 2005-10-05 | 2007-04-12 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| DK1944365T3 (da) | 2005-10-13 | 2012-04-30 | Kao Corp | Hidtil ukendt bacillus subtilis mutantstamme |
| KR101390085B1 (ko) * | 2006-03-31 | 2014-04-28 | 라이스 유니버시티 | 글리세롤의 혐기성 발효 |
| KR100885616B1 (ko) | 2006-06-26 | 2009-02-24 | 씨제이제일제당 (주) | 글리세롤을 이용한 아미노산의 생산 방법 |
| EP2570481B1 (en) | 2007-03-20 | 2014-11-26 | University of Florida Research Foundation, Inc. | Materials and methods for efficient succinate and malate production |
| JP2010521190A (ja) | 2007-03-23 | 2010-06-24 | メタボリック エクスプローラー | １，２−プロパンジオールの製造に有用な、代謝的に操作された微生物 |
| US20100279369A1 (en) | 2007-03-23 | 2010-11-04 | Metabolic Explorer | Metabolically engineered microorganism useful for the production of acetol |
| US20110039327A1 (en) * | 2007-05-18 | 2011-02-17 | Aaron Adriaan Winkler | Organic acid production by fungal cells |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| US20100330614A1 (en) * | 2007-11-06 | 2010-12-30 | Massachusetts Institute Of Technology | Global transcription machinery engineering targeting the rnap alpha subunit (rpoa) |
| EP2241630B1 (en) | 2007-12-06 | 2016-06-01 | Ajinomoto Co., Inc. | A method for producing an organic acid |
| CA2779262C (en) | 2008-10-31 | 2021-09-07 | Gevo, Inc. | Engineered microorganisms capable of converting pyruvate to isobutanol under anaerobic conditions |
| KR20120025450A (ko) | 2009-04-02 | 2012-03-15 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 석시네이트 생성을 위한 경로의 엔지니어링 |
-
2010
- 2010-11-17 WO PCT/US2010/057119 patent/WO2011063055A2/en not_active Ceased
- 2010-11-17 CN CN201080052398.3A patent/CN102666838B/zh active Active
- 2010-11-17 KR KR20127015612A patent/KR20120099258A/ko not_active Ceased
- 2010-11-17 KR KR1020167025628A patent/KR20160114184A/ko not_active Ceased
- 2010-11-17 BR BR112012011990A patent/BR112012011990A2/pt not_active Application Discontinuation
- 2010-11-17 US US13/503,999 patent/US9017976B2/en active Active
- 2010-11-17 EP EP10832141.5A patent/EP2501797A4/en not_active Withdrawn
- 2010-11-17 JP JP2012540031A patent/JP2013511277A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102666838B (zh) | 2018-04-10 |
| KR20120099258A (ko) | 2012-09-07 |
| WO2011063055A2 (en) | 2011-05-26 |
| EP2501797A2 (en) | 2012-09-26 |
| EP2501797A4 (en) | 2013-04-17 |
| WO2011063055A3 (en) | 2011-11-17 |
| US20120220000A1 (en) | 2012-08-30 |
| US9017976B2 (en) | 2015-04-28 |
| JP2013511277A (ja) | 2013-04-04 |
| CN102666838A (zh) | 2012-09-12 |
| KR20160114184A (ko) | 2016-10-04 |
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