CN102666838B - 用于高效产生化学品的工程化微生物 - Google Patents

用于高效产生化学品的工程化微生物 Download PDF

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CN102666838B
CN102666838B CN201080052398.3A CN201080052398A CN102666838B CN 102666838 B CN102666838 B CN 102666838B CN 201080052398 A CN201080052398 A CN 201080052398A CN 102666838 B CN102666838 B CN 102666838B
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gene
mutation
naturally occurring
succinate
strain
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CN102666838A (zh
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龚巍
S·多勒
T·格拉巴
A·C·科拉德
J·G·佩罗
R·R·约卡姆
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PTT Global Chemical PCL
PTTGC Innovation America Corp
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Myriant Corp
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • High Energy & Nuclear Physics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201080052398.3A 2009-11-18 2010-11-17 用于高效产生化学品的工程化微生物 Active CN102666838B (zh)

Applications Claiming Priority (3)

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US28148109P 2009-11-18 2009-11-18
US61/281,481 2009-11-18
PCT/US2010/057119 WO2011063055A2 (en) 2009-11-18 2010-11-17 Engineering microbes for efficient production of chemicals

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CN102666838A CN102666838A (zh) 2012-09-12
CN102666838B true CN102666838B (zh) 2018-04-10

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US (1) US9017976B2 (enExample)
EP (1) EP2501797A4 (enExample)
JP (1) JP2013511277A (enExample)
KR (2) KR20160114184A (enExample)
CN (1) CN102666838B (enExample)
BR (1) BR112012011990A2 (enExample)
WO (1) WO2011063055A2 (enExample)

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CA2862051A1 (en) * 2012-01-30 2013-08-08 Myriant Corporation Production of muconic acid from genetically engineered microorganisms
CN102994436A (zh) * 2012-10-29 2013-03-27 江南大学 一种产减毒类脂a的大肠杆菌基因工程菌及其应用
JP6085190B2 (ja) * 2013-02-26 2017-02-22 花王株式会社 変異微生物及びそれを用いた有用物質の生産方法
KR101594156B1 (ko) 2013-06-25 2016-02-15 씨제이제일제당 주식회사 Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법
ES2908342T3 (es) * 2013-07-23 2022-04-28 Ptt Global Chemical Public Co Ltd Método de producción de ácido succínico utilizando difusión facilitada para la importación de azúcar
CN105705647B (zh) 2013-09-03 2020-03-27 Ptt全球化学公众有限公司 从1，3-丙二醇制造丙烯酸、丙烯腈和1，4-丁二醇的方法
CN104046586B (zh) * 2014-07-02 2016-08-17 山东大学 一株基因工程菌及其在生产(2r,3r)-2,3-丁二醇中的应用
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CN109415684B (zh) 2016-03-02 2022-06-07 Ptt全球化学公众有限公司 从基因工程微生物改进的黏康酸生产
PT3448859T (pt) 2017-03-20 2019-10-25 Forma Therapeutics Inc Composições de pirrolopirrole como ativadores de piruvato quinase (pkr).
CA3068459A1 (en) 2017-06-30 2019-01-03 Ptt Global Chemical Public Company Limited Microorganism with stabilized copy number of functional dna sequence and associated methods
US12053458B2 (en) 2018-09-19 2024-08-06 Novo Nordisk Health Care Ag Treating sickle cell disease with a pyruvate kinase R activating compound
ES2989438T3 (es) 2018-09-19 2024-11-26 Novo Nordisk Healthcare Ag Activación de la piruvato cinasa R
CN109251941B (zh) * 2018-09-30 2020-11-06 江南大学 一种高产琥珀酸的大肠杆菌及其应用
KR102129379B1 (ko) * 2018-10-10 2020-07-02 한국과학기술원 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법
CN114615977B (zh) 2019-09-19 2025-01-14 诺沃挪第克健康护理股份公司 丙酮酸激酶r(pkr)活化组合物
CN113278641B (zh) * 2020-05-27 2022-06-21 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组大肠杆菌、其构建方法及其应用
IT202000013243A1 (it) 2020-06-04 2021-12-04 Novamont Spa Processo per la purificazione di una miscela di dioli
IT202000031979A1 (it) 2020-12-22 2022-06-22 Novamont Spa Processo di purificazione di una miscela comprendente dioli e acetali
IT202100006419A1 (it) 2021-03-17 2022-09-17 Novamont Spa Recupero di dioli da una miscela
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
IT202100030572A1 (it) 2021-12-02 2023-06-02 Novamont Spa 1,3-butandiolo purificato da una miscela di dioli
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WO2011063055A2 (en) 2011-05-26
CN102666838A (zh) 2012-09-12
KR20120099258A (ko) 2012-09-07
BR112012011990A2 (pt) 2015-09-29
EP2501797A4 (en) 2013-04-17
EP2501797A2 (en) 2012-09-26
JP2013511277A (ja) 2013-04-04
US9017976B2 (en) 2015-04-28
US20120220000A1 (en) 2012-08-30
WO2011063055A3 (en) 2011-11-17
KR20160114184A (ko) 2016-10-04

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