KR20130116858A - 추출 발효에서 알코올 수거를 위한 오일 유래의 추출 용매 - Google Patents
추출 발효에서 알코올 수거를 위한 오일 유래의 추출 용매 Download PDFInfo
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- KR20130116858A KR20130116858A KR1020137001250A KR20137001250A KR20130116858A KR 20130116858 A KR20130116858 A KR 20130116858A KR 1020137001250 A KR1020137001250 A KR 1020137001250A KR 20137001250 A KR20137001250 A KR 20137001250A KR 20130116858 A KR20130116858 A KR 20130116858A
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- Prior art keywords
- oil
- extractant
- fatty
- alcohol
- fermentation
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02E50/00—Technologies for the production of fuel of non-fossil origin
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Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35629010P | 2010-06-18 | 2010-06-18 | |
| US61/356,290 | 2010-06-18 | ||
| US36844410P | 2010-07-28 | 2010-07-28 | |
| US36842910P | 2010-07-28 | 2010-07-28 | |
| US36843610P | 2010-07-28 | 2010-07-28 | |
| US36845110P | 2010-07-28 | 2010-07-28 | |
| US61/368,429 | 2010-07-28 | ||
| US61/368,444 | 2010-07-28 | ||
| US61/368,451 | 2010-07-28 | ||
| US61/368,436 | 2010-07-28 | ||
| US37954610P | 2010-09-02 | 2010-09-02 | |
| US61/379,546 | 2010-09-02 | ||
| US201161440034P | 2011-02-07 | 2011-02-07 | |
| US61/440,034 | 2011-02-07 | ||
| US13/160,766 US9012190B2 (en) | 2011-06-15 | 2011-06-15 | Use of thiamine and nicotine adenine dinucleotide for butanol production |
| US13/160,766 | 2011-06-15 | ||
| PCT/US2011/040842 WO2011159991A1 (en) | 2010-06-18 | 2011-06-17 | Extraction solvents derived from oil for alcohol removal in extractive fermentation |
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| KR20130116858A true KR20130116858A (ko) | 2013-10-24 |
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Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE044304T2 (hu) | 2010-06-18 | 2019-10-28 | Butamax Tm Advanced Biofuels | Olajból nyert oldószerek kivonása alkoholeltávolításra extraháló fermentációban |
| US20130040340A1 (en) * | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| BR112013024329A2 (pt) * | 2011-03-23 | 2017-12-19 | Butamax Tm Advanced Biofuels | métodos, célula hospedeira recombinante, método de aumento de tolerância de um micro-organismo que produz álcool ao álcool produzido, de pressão de ésteres butílicos durante uma fermentação, meio de fermentação e produto de alimentação animal |
| US8765425B2 (en) | 2011-03-23 | 2014-07-01 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
| EP2689014B1 (en) | 2011-03-24 | 2019-04-24 | Butamax (TM) Advanced Biofuels LLC | Host cells and methods for production of isobutanol |
| US20130164795A1 (en) * | 2011-06-17 | 2013-06-27 | Butamax(Tm) Advanced Biofuels Llc | Co-products from biofuel production processes and methods of making |
| US20130180164A1 (en) | 2011-07-28 | 2013-07-18 | Butamax(Tm) Advanced Biofuels Llc | Low sulfur fuel compositions having improved lubricity |
| EP2798072A2 (en) | 2011-12-30 | 2014-11-05 | Butamax Advanced Biofuels LLC | Fermentative production of alcohols |
| CN104271753B (zh) | 2012-04-25 | 2017-04-05 | 普拉克生化公司 | 发酵方法 |
| US9732362B2 (en) | 2012-05-04 | 2017-08-15 | Butamax Advanced Biofuels Llc | Processes and systems for alcohol production and recovery |
| JP6226286B2 (ja) * | 2012-06-21 | 2017-11-08 | 月島機械株式会社 | バイオマスの処理装置および処理方法 |
| WO2014007622A1 (en) | 2012-07-04 | 2014-01-09 | Coöperatie Avebe U.A. | Lipase in short-chain esterification of fatty acids |
| US20140024064A1 (en) | 2012-07-23 | 2014-01-23 | Butamax(Tm) Advanced Biofuels Llc | Processes and systems for the production of fermentative alcohols |
| MX2015000896A (es) * | 2012-07-23 | 2015-04-10 | Butamax Advanced Biofuels Llc | Procesos y sistemas para la produccion de productos de fermentacion. |
| WO2014043288A1 (en) | 2012-09-12 | 2014-03-20 | Butamax Advanced Biofuels Llc | Processes and systems for the production of fermentation products |
| CA2887574A1 (en) * | 2012-10-11 | 2014-04-17 | Butamax Advanced Biofuels Llc | Processes and systems for the production of fermentation products |
| WO2014138590A2 (en) * | 2013-03-07 | 2014-09-12 | Ls9, Inc. | Downstream processing of fatty alcohol compositions produced by recombinant host cells |
| WO2014159309A1 (en) | 2013-03-12 | 2014-10-02 | Butamax Advanced Biofuels Llc | Processes and systems for the production of alcohols |
| BR112015020685A2 (pt) * | 2013-03-15 | 2017-07-18 | Butamax Advanced Biofuels Llc | método para a recuperação do butanol, composição, métodos para a extração de álcool e de secagem |
| JP2015037389A (ja) * | 2013-08-19 | 2015-02-26 | 独立行政法人産業技術総合研究所 | 脂質分解酵素及び非イオン性界面活性剤添加によるリグノセルロース系バイオマスからの酵素糖化反応および同時糖化発酵の改善方法 |
| RU2555537C2 (ru) * | 2013-10-14 | 2015-07-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" | Способ очистки гидролизатов лигноцеллюлозного сырья от ингибиторов ацетонобутилового брожения |
| WO2015103002A1 (en) * | 2013-12-31 | 2015-07-09 | Butamax Advanced Biofuels Llc | Isobutanol tolerance in yeast with an altered lipid profile |
| KR101485905B1 (ko) * | 2014-10-06 | 2015-01-26 | 김준호 | 이산화탄소 감소효과를 갖는 지방산효소에너지 조성물 및 이의 제조방법 |
| EP3488009B1 (en) | 2016-07-22 | 2021-02-17 | VITO NV (Vlaamse Instelling voor Technologisch Onderzoek NV) | Method and apparatus for producing solvents by fermentation |
| CN108265088A (zh) * | 2017-01-03 | 2018-07-10 | 北京化工大学 | 一种利用脂肪酶催化醇类发酵产物制备酯类化合物的方法 |
| CN110312558B (zh) * | 2017-03-20 | 2021-10-15 | 朗泽科技有限公司 | 用于产物回收和细胞再循环的方法和系统 |
| EP3679150B1 (en) | 2017-09-05 | 2021-10-27 | Vito NV | Method and apparatus for in situ product recovery |
| EP3450564A1 (en) | 2017-09-05 | 2019-03-06 | Vito NV | Method of producing organic solvents in a bioreactor |
| CN108315359B (zh) * | 2018-03-23 | 2021-07-27 | 安玉民 | 利用马铃薯秸秆制取酒精和调配饲料的方法 |
| CN110645725A (zh) * | 2019-09-29 | 2020-01-03 | 广东利人酒业有限公司 | 一种低温冷冻过滤系统 |
| CN116508784B (zh) * | 2023-05-11 | 2024-01-19 | 南京工业大学 | 棕榈酸在提高施氏假单胞菌在促进植物生长和减少农田土壤氧化亚氮排放中的应用 |
| WO2024238681A1 (en) * | 2023-05-16 | 2024-11-21 | Icm, Inc. | Feed product and method of making |
| WO2025242894A1 (en) * | 2024-05-24 | 2025-11-27 | Firmenich Sa | Modified biomass extracts |
| CN119639266B (zh) * | 2025-02-13 | 2025-07-25 | 江苏冠军科技集团股份有限公司 | 一种生物基环保溶剂稀释剂及其制备方法和应用 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57152890A (en) * | 1981-03-16 | 1982-09-21 | Nippon Kagaku Kikai Seizo Kk | Alcoholic fermentation of syrup made from starch |
| JPS5992094A (ja) * | 1982-11-18 | 1984-05-28 | Agency Of Ind Science & Technol | 有機廃棄物の嫌気性消化方法 |
| JPS59216591A (ja) * | 1983-05-23 | 1984-12-06 | Chiyoda Chem Eng & Constr Co Ltd | ブタノ−ルの製造法 |
| JPS60172290A (ja) * | 1984-02-17 | 1985-09-05 | Kao Corp | ブタノ−ルの製造方法 |
| JPS61173786A (ja) * | 1985-01-28 | 1986-08-05 | Mitsui Eng & Shipbuild Co Ltd | アルコ−ル発酵法 |
| ATE47884T1 (de) * | 1985-04-09 | 1989-11-15 | Voest Alpine Ag | Verfahren zur gleichzeitigen produktion von alkohol und proteinreichen futtermitteln. |
| US4865973A (en) * | 1985-09-13 | 1989-09-12 | Queen's University At Kingston | Process for extractive fermentation |
| DE4230645C2 (de) | 1992-09-12 | 1996-03-07 | Bernd Hansen | Ampulle |
| AU2388295A (en) | 1994-04-15 | 1995-11-10 | Midwest Research Institute | Recombinant zymomonas for pentose fermentation |
| US5514583A (en) | 1994-04-15 | 1996-05-07 | Midwest Research Institute | Recombinant zymomonas for pentose fermentation |
| US5712133A (en) | 1994-04-15 | 1998-01-27 | Midwest Research Institute | Pentose fermentation by recombinant zymomonas |
| US7223575B2 (en) | 2000-05-01 | 2007-05-29 | Midwest Research Institute | Zymomonas pentose-sugar fermenting strains and uses thereof |
| JP2004208667A (ja) * | 2003-01-06 | 2004-07-29 | Minoru Morita | バイオマス資源を利用したエタノール製造方法 |
| CN1183238C (zh) * | 2003-03-28 | 2005-01-05 | 刘阳 | 生物酶法制造植物油脂肪酸甲酯的新方法 |
| US20070014905A1 (en) * | 2003-06-30 | 2007-01-18 | Purdue Research Foundation | Starchy material processed to produce one or more products comprising starch, ethanol, sugar syrup, oil, protein, fiber, gluten meal, and mixtures thereof |
| HUE051490T2 (hu) * | 2004-03-25 | 2021-03-01 | Novozymes Inc | Eljárások növényi sejtfal-poliszacharidok lebontására vagy átalakítására |
| TWI240384B (en) * | 2004-04-16 | 2005-09-21 | Powerchip Semiconductor Corp | Method of manufacturing non-volatile memory cell |
| WO2006110900A2 (en) | 2005-04-12 | 2006-10-19 | E. I. Du Pont De Nemours And Company | Treatment of biomass to obtain ethanol |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| US8956850B2 (en) | 2008-06-05 | 2015-02-17 | Butamax Advanced Biofuels Llc | Enhanced pyruvate to acetolactate conversion in yeast |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| US7666282B2 (en) | 2005-12-28 | 2010-02-23 | E.I. Du Pont De Nemours And Company | Process for providing ethanol |
| JP2007245096A (ja) * | 2006-03-17 | 2007-09-27 | Tokyo Electric Power Co Inc:The | バイオマスから有用物質を製造する方法 |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| CN101454457A (zh) * | 2006-05-02 | 2009-06-10 | 纳幕尔杜邦公司 | 四碳醇的发酵生产 |
| DE102006040567A1 (de) * | 2006-08-30 | 2008-03-06 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von Bioethanol |
| CA2663128A1 (en) | 2006-09-26 | 2008-04-03 | Verasun Energy Corporation | Solvent extraction of oil from distillers dried grains and methods of using extraction products |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| CN101595218A (zh) * | 2006-10-31 | 2009-12-02 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产丁醇 |
| US20100036174A1 (en) * | 2006-10-31 | 2010-02-11 | Lourina Madeleine Raamsdonk | Butanol production in a eukaryotic cell |
| US20090030537A1 (en) | 2007-03-19 | 2009-01-29 | Allen Hartle | Interactive radio system and method |
| WO2008130995A2 (en) | 2007-04-18 | 2008-10-30 | E. I. Du Pont De Nemours And Company | Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes |
| JP2008278825A (ja) * | 2007-05-11 | 2008-11-20 | Chuo Kakoki Kk | バイオエタノールの製造方法 |
| US8192968B2 (en) * | 2007-08-27 | 2012-06-05 | Iogen Energy Corporation | Method for the production of a fermentation product from a pretreated lignocellulosic feedstock |
| JP4707007B2 (ja) * | 2007-10-05 | 2011-06-22 | 智浩 青戸 | ヤーコンからエタノールを製造する方法及び装置 |
| JP2009106258A (ja) * | 2007-10-12 | 2009-05-21 | Nippon Steel Engineering Co Ltd | エタノール製造方法 |
| US7897396B2 (en) | 2007-10-30 | 2011-03-01 | E.I. Du Pont De Nemours And Company | Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate |
| EP2225373A4 (en) * | 2007-12-13 | 2014-04-30 | Glycos Biotechnologies Inc | MICROBIAL CONVERSION OF OILS AND FATTY ACIDS IN HIGH-VALUE CHEMICALS |
| EP2677028B1 (en) | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| CN101952448A (zh) * | 2007-12-23 | 2011-01-19 | 格沃股份有限公司 | 高产率产生异丁醇的酵母生物 |
| BRPI0821519A2 (pt) | 2007-12-27 | 2015-06-16 | Gevo Inc | Recuperação de alcoois superiores a partir de soluções aquosas diluída |
| WO2009089030A1 (en) * | 2008-01-08 | 2009-07-16 | Integroextraction, Inc. | Dry-mill ethanol plant extraction enhancement |
| JP2009213449A (ja) * | 2008-03-12 | 2009-09-24 | Tokyo Electric Power Co Inc:The | 油系植物バイオマス残渣を原料とする単糖類、エタノールの製造方法 |
| JP2011515107A (ja) | 2008-03-27 | 2011-05-19 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 改善されたキシロース資化能を有するザイモモナス(Zymomonas) |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| NZ588988A (en) | 2008-06-04 | 2012-08-31 | Butamax Tm Advanced Biofuels | A method for producing butanol using two-phase extractive fermentation |
| EP2821484B1 (en) | 2008-09-29 | 2016-06-29 | Butamax Advanced Biofuels LLC | Identification and use of Bacterial [2Fe-2S] dihydroxy-acid dehydratases |
| CN101418320B (zh) * | 2008-12-10 | 2011-05-18 | 中国科学院微生物研究所 | 一种生产丁醇的方法 |
| US8247208B2 (en) | 2008-12-22 | 2012-08-21 | Alliance For Sustainable Energy Llc | Zymomonas with improved xylose utilization in stress conditions |
| EP2419517A2 (en) * | 2009-04-13 | 2012-02-22 | Butamax(TM) Advanced Biofuels LLC | Method for producing butanol using extractive fermentation |
| US9260708B2 (en) | 2009-09-29 | 2016-02-16 | Butamax Advanced Biofuels Llc | Yeast production host cells |
| JP2013511284A (ja) * | 2009-11-23 | 2013-04-04 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | オスモライトの添加を伴う抽出発酵を用いたブタノールの生成方法 |
| HUE044304T2 (hu) * | 2010-06-18 | 2019-10-28 | Butamax Tm Advanced Biofuels | Olajból nyert oldószerek kivonása alkoholeltávolításra extraháló fermentációban |
| US10079208B2 (en) | 2016-07-28 | 2018-09-18 | Globalfoundries Inc. | IC structure with interface liner and methods of forming same |
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