KR20120099258A - 화합물들의 효과적인 생산을 위한 미생물 엔지니어링 - Google Patents

화합물들의 효과적인 생산을 위한 미생물 엔지니어링 Download PDF

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KR20120099258A
KR20120099258A KR20127015612A KR20127015612A KR20120099258A KR 20120099258 A KR20120099258 A KR 20120099258A KR 20127015612 A KR20127015612 A KR 20127015612A KR 20127015612 A KR20127015612 A KR 20127015612A KR 20120099258 A KR20120099258 A KR 20120099258A
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gene
mutations
strain
production
succinic acid
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Korean (ko)
Inventor
웨이 공
수단슈 돌
타미 그라바
앤드류 크리스토퍼 콜라드
재니스 지. 페로
알. 로져스 요컴
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미리안트 코포레이션
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    • C12N9/10Transferases (2.)
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    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR20127015612A 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링 Ceased KR20120099258A (ko)

Applications Claiming Priority (2)

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US28148109P 2009-11-18 2009-11-18
US61/281,481 2009-11-18

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KR1020167025628A Division KR20160114184A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링

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KR20120099258A true KR20120099258A (ko) 2012-09-07

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KR20127015612A Ceased KR20120099258A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링
KR1020167025628A Ceased KR20160114184A (ko) 2009-11-18 2010-11-17 화합물들의 효과적인 생산을 위한 미생물 엔지니어링

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US (1) US9017976B2 (enExample)
EP (1) EP2501797A4 (enExample)
JP (1) JP2013511277A (enExample)
KR (2) KR20120099258A (enExample)
CN (1) CN102666838B (enExample)
BR (1) BR112012011990A2 (enExample)
WO (1) WO2011063055A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9758771B2 (en) 2013-06-25 2017-09-12 Cj Cheiljedang Corporation Microorganism with enhanced L-lysine productivity and method for producing L-lysine by using same

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120103645A (ko) * 2009-11-18 2012-09-19 미리안트 코포레이션 유기산들을 생산하는 대장균의 대사적 진화
WO2012019175A2 (en) 2010-08-06 2012-02-09 Mascoma Corporation Production of malonyl-coa drived products via anaerobic pathways
JP2015504688A (ja) * 2012-01-30 2015-02-16 ミリアント・コーポレイションMyriant Corporation 遺伝子操作された微生物からのムコン酸の生成
CN102994436A (zh) * 2012-10-29 2013-03-27 江南大学 一种产减毒类脂a的大肠杆菌基因工程菌及其应用
JP6085190B2 (ja) * 2013-02-26 2017-02-22 花王株式会社 変異微生物及びそれを用いた有用物質の生産方法
CN105452445B (zh) * 2013-07-23 2020-08-21 Ptt全球化学公众有限公司 利用用于糖输入的易化扩散生产琥珀酸和其它化学品的方法
EP3041942B1 (en) 2013-09-03 2020-07-01 PTT Global Chemical Public Company Limited A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
CN104046586B (zh) * 2014-07-02 2016-08-17 山东大学 一株基因工程菌及其在生产(2r,3r)-2,3-丁二醇中的应用
CN107208118A (zh) * 2014-09-18 2017-09-26 基因组股份公司 具有提高的能源效率的非天然微生物
US10301613B2 (en) 2015-09-15 2019-05-28 Arizona Board Of Regents On Behalf Of Arizona State University Targeted remodeling of prokaryotic genomes using CRISPR-nickases
EP3423563B1 (en) 2016-03-02 2023-05-24 PTT Global Chemical Public Company Limited Improved muconic acid production from genetically engineered microorganisms
MD3448859T2 (ro) 2017-03-20 2020-03-31 Forma Therapeutics Inc Compoziții de pirolopirol în calitate de activatori ai piruvatkinazei (PKR)
KR102683624B1 (ko) 2017-06-30 2024-07-11 피티티 글로벌 케미칼 피씨엘 기능적 dna 서열의 안정화된 카피 수를 갖는 미생물 및 관련 방법
WO2020061378A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
ES2989438T3 (es) 2018-09-19 2024-11-26 Novo Nordisk Healthcare Ag Activación de la piruvato cinasa R
CN109251941B (zh) * 2018-09-30 2020-11-06 江南大学 一种高产琥珀酸的大肠杆菌及其应用
KR102129379B1 (ko) * 2018-10-10 2020-07-02 한국과학기술원 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법
AU2020350763A1 (en) 2019-09-19 2022-04-07 Novo Nordisk Health Care Ag Pyruvate kinase R (PKR) activating compositions
CN113278641B (zh) * 2020-05-27 2022-06-21 安徽华恒生物科技股份有限公司 生产l-缬氨酸的重组大肠杆菌、其构建方法及其应用
IT202000013243A1 (it) 2020-06-04 2021-12-04 Novamont Spa Processo per la purificazione di una miscela di dioli
IT202000031979A1 (it) 2020-12-22 2022-06-22 Novamont Spa Processo di purificazione di una miscela comprendente dioli e acetali
IT202100006419A1 (it) 2021-03-17 2022-09-17 Novamont Spa Recupero di dioli da una miscela
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
IT202100030572A1 (it) 2021-12-02 2023-06-02 Novamont Spa 1,3-butandiolo purificato da una miscela di dioli
CN118546852B (zh) * 2024-07-30 2024-10-18 北京化工大学 一种高效共利用葡萄糖、木糖生产丁二酸的基因工程菌及其应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947186B1 (en) 1995-05-05 2011-11-16 Danisco US Inc. Application of glucose transport mutants for production of aromatic pathway compounds
MY121380A (en) 1998-04-13 2006-01-28 Univ Georgia Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6989265B2 (en) 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome
US7303906B2 (en) 2002-09-06 2007-12-04 Wisconsin Alumni Research Foundation Competent bacteria
KR101148255B1 (ko) 2002-10-04 2012-08-08 다니스코 유에스 인크. 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법
US7232665B2 (en) 2002-12-19 2007-06-19 E. I. Du Pont De Nemours And Company Mutations affecting carotenoid production
DE10314618A1 (de) 2003-04-01 2004-10-14 Degussa Ag Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
CN103555782B (zh) 2003-10-21 2017-04-12 嘉吉有限公司 生产莫纳甜和莫纳甜前体
KR100576342B1 (ko) 2004-02-05 2006-05-03 씨제이 주식회사 galR 유전자가 불활성화된 L-쓰레오닌 생성 미생물,그를 제조하는 방법 및 상기 미생물을 이용한L-쓰레오닌의 제조방법
US20050181488A1 (en) 2004-02-12 2005-08-18 Akhverdian Valery Z. Method for producing L-threonine using bacteria belonging to the genus Escherichia
KR101245428B1 (ko) 2004-08-27 2013-03-19 라이스 유니버시티 숙신산 생산이 증가된 돌연변이 대장균 균주
US20060073577A1 (en) 2004-09-17 2006-04-06 San Ka-Yiu High succinate producing bacteria
US20080009041A1 (en) 2004-11-26 2008-01-10 Hiroshi Mizoguchi Industrially Useful Microorganism
KR100630836B1 (ko) 2005-04-08 2006-10-02 한국과학기술원 인-실리코 분석을 통한 균주 개량방법
US7524660B2 (en) 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
EP2305826B1 (en) 2005-08-10 2016-03-30 University of Florida Research Foundation, Inc. Materials and methods for efficient lactic acid production
US8178339B2 (en) 2005-08-20 2012-05-15 Scarab Genomics Llc Reduced genome E. coli
EP1937821A4 (en) 2005-09-09 2009-11-11 Genomatica Inc PROCESS AND ORGANISMS FOR GROWTH-COUPLED PRODUCTION OF SUCCINATE
DE102005047596A1 (de) 2005-10-05 2007-04-12 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
DK1944365T3 (da) 2005-10-13 2012-04-30 Kao Corp Hidtil ukendt bacillus subtilis mutantstamme
KR101390085B1 (ko) * 2006-03-31 2014-04-28 라이스 유니버시티 글리세롤의 혐기성 발효
KR100885616B1 (ko) 2006-06-26 2009-02-24 씨제이제일제당 (주) 글리세롤을 이용한 아미노산의 생산 방법
EP2570481B1 (en) 2007-03-20 2014-11-26 University of Florida Research Foundation, Inc. Materials and methods for efficient succinate and malate production
JP2010521190A (ja) 2007-03-23 2010-06-24 メタボリック エクスプローラー 1,2−プロパンジオールの製造に有用な、代謝的に操作された微生物
US20100279369A1 (en) 2007-03-23 2010-11-04 Metabolic Explorer Metabolically engineered microorganism useful for the production of acetol
US20110039327A1 (en) * 2007-05-18 2011-02-17 Aaron Adriaan Winkler Organic acid production by fungal cells
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
US20100330614A1 (en) * 2007-11-06 2010-12-30 Massachusetts Institute Of Technology Global transcription machinery engineering targeting the rnap alpha subunit (rpoa)
EP2241630B1 (en) 2007-12-06 2016-06-01 Ajinomoto Co., Inc. A method for producing an organic acid
CA2779262C (en) 2008-10-31 2021-09-07 Gevo, Inc. Engineered microorganisms capable of converting pyruvate to isobutanol under anaerobic conditions
KR20120025450A (ko) 2009-04-02 2012-03-15 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 석시네이트 생성을 위한 경로의 엔지니어링

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9758771B2 (en) 2013-06-25 2017-09-12 Cj Cheiljedang Corporation Microorganism with enhanced L-lysine productivity and method for producing L-lysine by using same

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CN102666838B (zh) 2018-04-10
WO2011063055A2 (en) 2011-05-26
EP2501797A2 (en) 2012-09-26
EP2501797A4 (en) 2013-04-17
BR112012011990A2 (pt) 2015-09-29
WO2011063055A3 (en) 2011-11-17
US20120220000A1 (en) 2012-08-30
US9017976B2 (en) 2015-04-28
JP2013511277A (ja) 2013-04-04
CN102666838A (zh) 2012-09-12
KR20160114184A (ko) 2016-10-04

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