KR20120051777A - 스피로피페리딘 화합물 및 당뇨병의 치료를 위한 그의 제약 용도 - Google Patents
스피로피페리딘 화합물 및 당뇨병의 치료를 위한 그의 제약 용도 Download PDFInfo
- Publication number
- KR20120051777A KR20120051777A KR1020127009501A KR20127009501A KR20120051777A KR 20120051777 A KR20120051777 A KR 20120051777A KR 1020127009501 A KR1020127009501 A KR 1020127009501A KR 20127009501 A KR20127009501 A KR 20127009501A KR 20120051777 A KR20120051777 A KR 20120051777A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- group
- mmol
- compounds
- phenyl
- Prior art date
Links
- 0 **(C=C(CBr)C=C1)C=C1C(O*)=O Chemical compound **(C=C(CBr)C=C1)C=C1C(O*)=O 0.000 description 8
- UOTPMHPIKZILOJ-UHFFFAOYSA-N CC#CC(CC(OC)=O)c(c(F)c1)ccc1OCc1ccc(CN(CC2)CCC22c3ccccc3C=C2)cc1 Chemical compound CC#CC(CC(OC)=O)c(c(F)c1)ccc1OCc1ccc(CN(CC2)CCC22c3ccccc3C=C2)cc1 UOTPMHPIKZILOJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25183909P | 2009-10-15 | 2009-10-15 | |
| US61/251,839 | 2009-10-15 | ||
| US30333410P | 2010-02-11 | 2010-02-11 | |
| US61/303,334 | 2010-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120051777A true KR20120051777A (ko) | 2012-05-22 |
Family
ID=43719548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127009501A KR20120051777A (ko) | 2009-10-15 | 2010-10-11 | 스피로피페리딘 화합물 및 당뇨병의 치료를 위한 그의 제약 용도 |
Country Status (24)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014171762A1 (ko) * | 2013-04-18 | 2014-10-23 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| WO2016060517A3 (ko) * | 2014-10-17 | 2016-09-15 | 현대약품 주식회사 | 신규한 3-(4- (벤질옥시)페닐)핵스- 4-이노익 산 유도체 및 다른 유효 성분을 포함하는 대사성 질환의 예방 또는 치료용 복합제제 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2456515T3 (es) | 2009-03-23 | 2014-04-22 | Glenmark Pharmaceuticals S.A. | Derivados de pirimidindiona fusionados como moduladores de TRPA1 |
| PT2411395E (pt) | 2009-03-23 | 2013-06-06 | Glenmark Pharmaceuticals Sa | Derivados de furopirimidinadiona como moduladores de trpa1 |
| AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
| NZ601408A (en) | 2009-12-25 | 2013-12-20 | Mochida Pharm Co Ltd | Novel 3-hydroxy-5-arylisothiazole derivative |
| WO2012046869A1 (ja) | 2010-10-08 | 2012-04-12 | 持田製薬株式会社 | 環状アミド誘導体 |
| CA2829351A1 (en) | 2011-03-11 | 2012-09-20 | Intercontinental Great Brands Llc | System and method of forming multilayer confectionery |
| JP5420796B2 (ja) | 2011-04-27 | 2014-02-19 | 持田製薬株式会社 | 新規３−ヒドロキシイソチアゾール１−オキシド誘導体 |
| JPWO2012147516A1 (ja) | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
| AR087451A1 (es) | 2011-08-17 | 2014-03-26 | Lilly Co Eli | Derivado de 1,2,3,4-tetrahidroquinolina util para tratamiento de diabetes |
| WO2013139341A1 (en) * | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Gpr120 receptor modulators |
| WO2013185766A1 (en) * | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Gpr120 receptor modulators |
| CN104812748B (zh) | 2012-11-16 | 2017-10-24 | 百时美施贵宝公司 | 二氢吡唑gpr40调节剂 |
| CN105722841A (zh) * | 2013-11-14 | 2016-06-29 | 卡迪拉保健有限公司 | 新型杂环化合物 |
| US20150351889A1 (en) | 2014-06-05 | 2015-12-10 | Vivex Biomedical Inc. | Dynamic Biometric Mesh |
| CN109666027A (zh) * | 2017-10-17 | 2019-04-23 | 中国科学院上海药物研究所 | 一类酰胺结构的gpr40激动剂化合物及其用途 |
| DK3737470T5 (da) | 2018-01-08 | 2024-05-27 | Celon Pharma Sa | 3-phenyl-4-hexynsyrederivater som gpr40-agonister |
| SG11202007646UA (en) | 2018-02-13 | 2020-09-29 | Gilead Sciences Inc | Pd-1/pd-l1 inhibitors |
| TWI712412B (zh) | 2018-04-19 | 2020-12-11 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| TWI732245B (zh) | 2018-07-13 | 2021-07-01 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| CN112955435A (zh) | 2018-10-24 | 2021-06-11 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| BR112022006546A2 (pt) | 2019-10-07 | 2022-08-30 | Kallyope Inc | Agonistas de gpr119 |
| BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
| EP4172162A1 (en) | 2020-06-26 | 2023-05-03 | Kallyope, Inc. | Ampk activators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2316559T3 (es) * | 2001-04-18 | 2009-04-16 | Euro-Celtique S.A. | Compuestos espiroindeno y espiroindano. |
| RU2005134230A (ru) * | 2003-04-04 | 2006-05-10 | Мерк энд Ко., Инк. (US) | Ацилированные производные спиропиперидина как агонисты рецептора меланокортина-4 |
| CA2544602A1 (en) * | 2003-11-04 | 2005-05-26 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| WO2005051890A1 (en) | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| KR20070004769A (ko) | 2004-02-27 | 2007-01-09 | 암젠 인코포레이션 | 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법 |
| WO2005095338A1 (ja) * | 2004-03-30 | 2005-10-13 | Takeda Pharmaceutical Company Limited | アルコキシフェニルプロパン酸誘導体 |
| CA2621949A1 (en) * | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| CA2662242C (en) | 2006-09-07 | 2012-06-12 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| NZ584161A (en) | 2007-10-26 | 2011-12-22 | Japan Tobacco Inc | Spiro-ring compound and use thereof for medical purposes |
| CA2706391A1 (en) * | 2007-11-21 | 2009-05-28 | Janssen Pharmaceutica N.V. | Spiropiperidines for use as tryptase inhibitors |
| AR078948A1 (es) | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
-
2010
- 2010-10-04 AR ARP100103604A patent/AR078522A1/es not_active Application Discontinuation
- 2010-10-06 TW TW099134098A patent/TW201124415A/zh unknown
- 2010-10-11 CN CN2010800462763A patent/CN102574807A/zh active Pending
- 2010-10-11 PE PE2012000492A patent/PE20121437A1/es not_active Application Discontinuation
- 2010-10-11 KR KR1020127009501A patent/KR20120051777A/ko not_active Application Discontinuation
- 2010-10-11 MX MX2012004420A patent/MX2012004420A/es not_active Application Discontinuation
- 2010-10-11 WO PCT/US2010/052126 patent/WO2011046851A1/en active Application Filing
- 2010-10-11 US US12/901,597 patent/US8383642B2/en not_active Expired - Fee Related
- 2010-10-11 CA CA2777775A patent/CA2777775A1/en not_active Abandoned
- 2010-10-11 NZ NZ598972A patent/NZ598972A/xx not_active IP Right Cessation
- 2010-10-11 BR BR112012008889A patent/BR112012008889A2/pt not_active IP Right Cessation
- 2010-10-11 JP JP2012534259A patent/JP2013508279A/ja not_active Withdrawn
- 2010-10-11 AU AU2010307094A patent/AU2010307094A1/en not_active Abandoned
- 2010-10-11 EA EA201270560A patent/EA201270560A1/ru unknown
- 2010-10-11 EP EP10793349A patent/EP2488500A1/en not_active Withdrawn
-
2012
- 2012-02-27 IL IL218344A patent/IL218344A0/en unknown
- 2012-04-02 TN TNP2012000152A patent/TN2012000152A1/en unknown
- 2012-04-09 MA MA34760A patent/MA33662B1/fr unknown
- 2012-04-10 ZA ZA2012/02560A patent/ZA201202560B/en unknown
- 2012-04-12 CL CL2012000921A patent/CL2012000921A1/es unknown
- 2012-04-12 CR CR20120177A patent/CR20120177A/es not_active Application Discontinuation
- 2012-04-13 DO DO2012000105A patent/DOP2012000105A/es unknown
- 2012-04-13 EC ECSP12011799 patent/ECSP12011799A/es unknown
- 2012-04-20 CO CO12065315A patent/CO6531458A2/es not_active Application Discontinuation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014171762A1 (ko) * | 2013-04-18 | 2014-10-23 | 현대약품 주식회사 | 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물 |
| CN105121423A (zh) * | 2013-04-18 | 2015-12-02 | 现代药品株式会社 | 新型3-(4-(苄氧基)苯基)己-4-炔酸衍生物、其制备方法、和包括其作为有效成分的用于预防和治疗代谢性疾病的药物组合物 |
| WO2016060517A3 (ko) * | 2014-10-17 | 2016-09-15 | 현대약품 주식회사 | 신규한 3-(4- (벤질옥시)페닐)핵스- 4-이노익 산 유도체 및 다른 유효 성분을 포함하는 대사성 질환의 예방 또는 치료용 복합제제 |
| AU2015331074B2 (en) * | 2014-10-17 | 2018-11-15 | Hyundai Pharm Co., Ltd. | Composite preparation, containing novel 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases |
| US10821110B2 (en) | 2014-10-17 | 2020-11-03 | Hyundai Pharm Co., Ltd. | Composite preparation, containing novel 3-(4--(benzyloxy)phenyl)hex-4-inoic acid derivative and another active ingredient, for preventing or treating metabolic diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| US8383642B2 (en) | 2013-02-26 |
| AR078522A1 (es) | 2011-11-16 |
| CN102574807A (zh) | 2012-07-11 |
| CL2012000921A1 (es) | 2012-09-14 |
| ECSP12011799A (es) | 2012-07-31 |
| EP2488500A1 (en) | 2012-08-22 |
| TW201124415A (en) | 2011-07-16 |
| IL218344A0 (en) | 2012-04-30 |
| CO6531458A2 (es) | 2012-09-28 |
| ZA201202560B (en) | 2013-09-25 |
| TN2012000152A1 (en) | 2013-12-12 |
| BR112012008889A2 (pt) | 2019-09-24 |
| US20110092531A1 (en) | 2011-04-21 |
| EA201270560A1 (ru) | 2012-09-28 |
| MX2012004420A (es) | 2012-05-08 |
| CR20120177A (es) | 2012-06-06 |
| MA33662B1 (fr) | 2012-10-01 |
| CA2777775A1 (en) | 2011-04-21 |
| PE20121437A1 (es) | 2012-10-26 |
| NZ598972A (en) | 2013-06-28 |
| WO2011046851A1 (en) | 2011-04-21 |
| DOP2012000105A (es) | 2013-01-31 |
| AU2010307094A1 (en) | 2012-04-19 |
| JP2013508279A (ja) | 2013-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |