KR20120039564A - 순수 ｐｅｇ-지질 컨쥬게이트 - Google Patents

순수 ｐｅｇ-지질 컨쥬게이트 Download PDF

Info

Publication number
KR20120039564A
KR20120039564A KR1020117031713A KR20117031713A KR20120039564A KR 20120039564 A KR20120039564 A KR 20120039564A KR 1020117031713 A KR1020117031713 A KR 1020117031713A KR 20117031713 A KR20117031713 A KR 20117031713A KR 20120039564 A KR20120039564 A KR 20120039564A
Authority
KR
South Korea
Prior art keywords
peg
glycerol
lipid
conjugates
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020117031713A
Other languages
English (en)
Korean (ko)
Inventor
니안 우
브라이언 찰스 켈러
Original Assignee
니안 우
브라이언 찰스 켈러
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 니안 우, 브라이언 찰스 켈러 filed Critical 니안 우
Publication of KR20120039564A publication Critical patent/KR20120039564A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
    • C08L63/10—Epoxy resins modified by unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
KR1020117031713A 2009-06-02 2010-06-01 순수 ｐｅｇ-지질 컨쥬게이트 Withdrawn KR20120039564A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21762709P 2009-06-02 2009-06-02
US61/217,627 2009-06-02
US28406509P 2009-12-12 2009-12-12
US61/284,065 2009-12-12

Publications (1)

Publication Number Publication Date
KR20120039564A true KR20120039564A (ko) 2012-04-25

Family

ID=43298359

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117031713A Withdrawn KR20120039564A (ko) 2009-06-02 2010-06-01 순수 ｐｅｇ-지질 컨쥬게이트

Country Status (15)

Country Link
US (1) US20110040113A1 (enExample)
EP (1) EP2437756A2 (enExample)
JP (1) JP2012528857A (enExample)
KR (1) KR20120039564A (enExample)
CN (1) CN102665685A (enExample)
AP (1) AP2012006053A0 (enExample)
AU (1) AU2010257181A1 (enExample)
BR (1) BRPI1010175A2 (enExample)
CA (1) CA2763819A1 (enExample)
CL (1) CL2011003049A1 (enExample)
CO (1) CO6511284A2 (enExample)
IL (1) IL216719A0 (enExample)
MX (1) MX2011012823A (enExample)
WO (1) WO2010141069A2 (enExample)
ZA (1) ZA201109366B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200132878A (ko) * 2018-03-20 2020-11-25 니치유 가부시키가이샤 분기형 단분산 폴리에틸렌 글리콜, 중간체 및 그 제조 방법

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393315B2 (en) 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
US20120202890A1 (en) 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
US20120232169A1 (en) * 2011-03-07 2012-09-13 Biozone Pharmaceuticals, Inc. Highly monodisperse branched peg-lipid conjugates
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
US8883177B2 (en) * 2011-06-28 2014-11-11 Nian Wu Pharmaceutical compositions for parenteral administration
JP6051758B2 (ja) * 2011-10-17 2016-12-27 日油株式会社 ジアシルグリセロールと結合した分岐型ポリエチレングリコール、その製造方法およびポリエチレングリコール修飾リポソーム
MX363822B (es) * 2012-08-21 2019-04-04 Opko Pharmaceuticals Llc Formulaciones de liposomas.
US11458199B2 (en) 2012-08-21 2022-10-04 Opko Pharmaceuticals, Llc Liposome formulations
US8980839B2 (en) 2012-08-24 2015-03-17 Ocular Technologies Sarl Topical aqueous nanomicellar, ophthalmic solutions and uses thereof
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
CN105792850A (zh) * 2013-12-05 2016-07-20 念·吴 聚合物-碳水化合物的缀合物的药物转递技术
JP6629736B2 (ja) * 2013-12-20 2020-01-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む、細胞を結合するのに有用な化合物
CN105829886B (zh) 2013-12-20 2018-04-03 豪夫迈·罗氏有限公司 使用包含聚乙二醇部分的化合物在支持物上固定细胞的方法
JP6461973B2 (ja) * 2013-12-20 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用
AU2015360794B2 (en) 2014-12-08 2021-07-08 The Board Of Regents Of The University Of Texas System Lipocationic polymers and uses thereof
US10064954B2 (en) 2015-06-23 2018-09-04 Nian Wu Polymer-cyclodextrin-lipid conjugates
JP7041616B2 (ja) 2015-09-14 2022-03-24 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム リポカチオン性デンドリマーおよびその使用
PL3373976T3 (pl) 2015-11-10 2024-06-24 Sun Pharmaceutical Industries Limited Preparaty do stosowania miejscowego i ich zastosowanie
JP7080172B2 (ja) 2015-12-10 2022-06-03 モデルナティエックス インコーポレイテッド 治療薬の送達のための組成物及び方法
CN106905120B (zh) * 2015-12-21 2020-04-28 北京键凯科技股份有限公司 Y型多缩乙二醇衍生物及其制备方法
US10918694B2 (en) 2016-02-29 2021-02-16 Sun Pharma Global Fze Topical cyclosporine-containing formulations and uses thereof
AU2017267634C1 (en) 2016-05-16 2022-05-26 The Board Of Regents Of The University Of Texas System Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
PL3458074T3 (pl) 2016-05-16 2024-11-12 Board Of Regents Of The University Of Texas System KOMPOZYCJA DO DOSTARCZANIA tRNA W POSTACI NANOCZĄSTEK I SPOSOBY ICH STOSOWANIA
CA3095299A1 (en) * 2018-03-29 2019-10-03 Nof Corporation Method for purifying trityl group-containing monodispersed polyethylene glycol
WO2019191597A1 (en) * 2018-03-30 2019-10-03 The Board Of Regents Of The University Of Oklahoma Very long chain saturated fatty acid compounds, compositions containing same, and methods of use
US12357580B2 (en) 2018-06-19 2025-07-15 The Board Of Regents Of The University Of Texas System Lipid nanoparticle compositions for delivery of mRNA and long nucleic acids
CN112996519B (zh) 2018-09-04 2025-02-28 德克萨斯大学系统董事会 用于核酸的器官特异性递送的组合物和方法
AU2019335055B2 (en) 2018-09-04 2025-05-29 The Board Of Regents Of The University Of Texas System Compositions and methods for organ specific delivery of nucleic acids
US12383508B2 (en) * 2018-09-19 2025-08-12 Modernatx, Inc. High-purity peg lipids and uses thereof
JP6805385B1 (ja) * 2020-08-31 2020-12-23 ジェイ−ネットワーク，インコーポレイテッド 表皮内の保湿関連物質の発現増強剤
CN116615235A (zh) 2020-10-09 2023-08-18 得克萨斯州大学系统董事会 融合前稳定的hmpv f蛋白
JP6860739B1 (ja) * 2020-11-20 2021-04-21 ジェイ−ネットワーク，インコーポレイテッド 表皮内の抗酸化物質の発現増強剤
CN114685778B (zh) * 2020-12-30 2023-10-17 苏州艾博生物科技有限公司 长循环阳离子脂质体的合成方法
AU2021425941A1 (en) 2021-02-08 2023-08-17 The Board Of Regents Of The University Of Texas System Unsaturated dendrimers compositions,related formulations, and methods of use thereof
IL306007A (en) 2021-03-23 2023-11-01 Recode Therapeutics Inc Polynucleotide preparations, related formulations and methods of using them
US20240207442A1 (en) 2021-04-22 2024-06-27 The Board Of Regents Of The University Of Texas System All-in-one dendrimer-based lipid nanoparticles enable precise hdr-mediated gene editing in vivo
EP4342929A4 (en) 2021-06-30 2024-10-30 Jenkem Technology Co. Ltd. (Tianjin) POLYETHYLENE GLYCOL LIPID AND ITS USE
CN113461929B (zh) * 2021-07-13 2023-04-21 浙江倍合德制药有限公司 一种tpgs系列产品的精制提纯方法
CN116410460B (zh) * 2021-12-29 2025-08-05 辅必成（上海）医药科技有限公司 一种1,2-二肉豆蔻酰-rac-甘油-3-甲氧基聚乙二醇2000的制备方法
CN114507342B (zh) * 2022-03-18 2024-03-19 江苏东南纳米材料有限公司 一种1,2-二肉豆蔻酰-rac-甘油-3-甲氧基聚乙二醇及其中间体的制备方法
US20250235404A1 (en) * 2022-04-05 2025-07-24 Capstan Therapeutics, Inc. Peg-lipids and lipid nanoparticles
CN114524943B (zh) * 2022-04-22 2022-09-16 天津凯莱英制药有限公司 聚乙二醇-甘油衍生物及其中间体各自的制备方法
CN117003807A (zh) * 2022-04-28 2023-11-07 北京科兴中维生物技术有限公司 一种结构脂质化合物及其制备方法和用途
IL320164A (en) * 2022-11-15 2025-06-01 Evonik Operations Gmbh Polyoxyalkylene-2,1-dimyristoyl-glycerol compounds where the polyoxyalkylene is poly(ethylene oxide) having C1 to C3-alkyloxymethyl side chains
WO2024123633A1 (en) 2022-12-08 2024-06-13 Recode Therapeutics, Inc. Lipid nanoparticle compositions and uses thereof
CN120569211A (zh) 2023-01-09 2025-08-29 得克萨斯州大学系统董事会 融合前稳定的人副流感病毒3f蛋白
CN116178733B (zh) * 2023-03-03 2023-08-01 浙江博美生物技术有限公司 一种基于三官能团氨基酸的支化单分散peg衍生物、制备方法和应用
US12364773B2 (en) 2023-12-01 2025-07-22 Recode Therapeutics, Inc. Lipid nanoparticle compositions and uses thereof
WO2025137646A1 (en) 2023-12-22 2025-06-26 Recode Therapeutics, Inc. Gene editing methods and compositions for treating cystic fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
NZ581166A (en) * 2003-09-15 2011-06-30 Protiva Biotherapeutics Inc Polyethyleneglycol-modified lipid compounds and uses thereof
WO2006007712A1 (en) * 2004-07-19 2006-01-26 Protiva Biotherapeutics, Inc. Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
WO2006051405A2 (en) * 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
EP2219587A4 (en) * 2007-11-14 2012-11-21 Univ California STEROL-MODIFIED AMPHIPHILE LIPIDES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200132878A (ko) * 2018-03-20 2020-11-25 니치유 가부시키가이샤 분기형 단분산 폴리에틸렌 글리콜, 중간체 및 그 제조 방법

Also Published As

Publication number Publication date
WO2010141069A3 (en) 2012-04-12
CO6511284A2 (es) 2012-08-31
BRPI1010175A2 (pt) 2016-03-29
MX2011012823A (es) 2012-06-25
EP2437756A2 (en) 2012-04-11
IL216719A0 (en) 2012-02-29
JP2012528857A (ja) 2012-11-15
CL2011003049A1 (es) 2012-07-13
ZA201109366B (en) 2012-08-29
AU2010257181A1 (en) 2012-01-12
CN102665685A (zh) 2012-09-12
CA2763819A1 (en) 2010-12-09
WO2010141069A2 (en) 2010-12-09
US20110040113A1 (en) 2011-02-17
AP2012006053A0 (en) 2012-02-29

Similar Documents

Publication Publication Date Title
KR20120039564A (ko) 순수 ｐｅｇ-지질 컨쥬게이트
US5880131A (en) High molecular weight polymer-based prodrugs
EP2729179B1 (en) Macromolecules
WO2012122144A1 (en) Highly monodisperse branched peg-lipid conjugates
US20020091288A1 (en) Discrete-length polyethylene glycols
AU717922B2 (en) Selectively functionalizable desdendrimers
CN102834435B (zh) 支化的紧凑型聚乙二醇衍生物
KR20250128306A (ko) 지질 화합물 및 지질 나노입자 조성물
JP2010504929A (ja) 生体系への送達を高める手段及び方法
JP3538606B2 (ja) パクリタキセルまたはその誘導体の残基を含む水溶性プロドラッグ化合物、その製造方法及びそれを含む薬剤組成物
US20240016946A1 (en) Drug-loaded macromolecule and preparation method therefor
TW202206106A (zh) 一類載藥的大分子及其製備方法
CN113952464B (zh) 含酮羰基的疏水性抗肿瘤药物及其应用
RU2837235C1 (ru) Макромолекула, несущая лекарственное средство, и способ ее получения
US11952461B2 (en) Siloxy polyethylene glycol and derivatives thereof
RU2849554C2 (ru) Конъюгат производного ε-поли-l-лизина с лекарственным средством, промежуточные соединения и их применение
CN114306632B (zh) 一种与人血清白蛋白非共价结合型7-乙基-10-羟基喜树碱衍生物前药、制备及应用
WO2024131717A1 (zh) 一种阳离子脂质材料的制备及应用
CN111253565A (zh) 一种小分子聚乙二醇修饰的磷脂类化合物及其制备方法和应用
Xu PREPARATION OF PEG-DERIVATIZED PPMP AS A DUAL-FUNCTIONAL CARRIER FOR ANTICANCER DRUGS
HK1198356B (en) Macromolecules

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20111230

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid