CL2011003049A1 - Composicion quimica incluyendo un conjugado peg-lipido, que comprende una columna vertebral de glicerol, un grupo lipido unido por enlace covalente a la columna vertebral de glicerol, una cadena peg unida por enlace covalente a la columna vertebral del glicerol; y liposoma que comprende dicha composicion. - Google Patents

Composicion quimica incluyendo un conjugado peg-lipido, que comprende una columna vertebral de glicerol, un grupo lipido unido por enlace covalente a la columna vertebral de glicerol, una cadena peg unida por enlace covalente a la columna vertebral del glicerol; y liposoma que comprende dicha composicion.

Info

Publication number
CL2011003049A1
CL2011003049A1 CL2011003049A CL2011003049A CL2011003049A1 CL 2011003049 A1 CL2011003049 A1 CL 2011003049A1 CL 2011003049 A CL2011003049 A CL 2011003049A CL 2011003049 A CL2011003049 A CL 2011003049A CL 2011003049 A1 CL2011003049 A1 CL 2011003049A1
Authority
CL
Chile
Prior art keywords
glycerol backbone
covalently linked
peg
lipid
liposome
Prior art date
Application number
CL2011003049A
Other languages
English (en)
Inventor
Nian Keller Brian Charles Wu
Original Assignee
Wu Nian
Keller Brian Charles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wu Nian, Keller Brian Charles filed Critical Wu Nian
Publication of CL2011003049A1 publication Critical patent/CL2011003049A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
    • C08L63/10—Epoxy resins modified by unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Abstract

Composición química incluyendo un conjugado peg-lípido, que comprende una columna vertebral de glicerol, un grupo lípido unido por enlace covalente a la columna vertebral de glicerol, una cadena peg unida por enlace covalente a la columna vertebral del glicerol; y liposoma que comprende dicha composición.
CL2011003049A 2009-06-02 2011-12-02 Composicion quimica incluyendo un conjugado peg-lipido, que comprende una columna vertebral de glicerol, un grupo lipido unido por enlace covalente a la columna vertebral de glicerol, una cadena peg unida por enlace covalente a la columna vertebral del glicerol; y liposoma que comprende dicha composicion. CL2011003049A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21762709P 2009-06-02 2009-06-02
US28406509P 2009-12-12 2009-12-12

Publications (1)

Publication Number Publication Date
CL2011003049A1 true CL2011003049A1 (es) 2012-07-13

Family

ID=43298359

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011003049A CL2011003049A1 (es) 2009-06-02 2011-12-02 Composicion quimica incluyendo un conjugado peg-lipido, que comprende una columna vertebral de glicerol, un grupo lipido unido por enlace covalente a la columna vertebral de glicerol, una cadena peg unida por enlace covalente a la columna vertebral del glicerol; y liposoma que comprende dicha composicion.

Country Status (15)

Country Link
US (1) US20110040113A1 (es)
EP (1) EP2437756A2 (es)
JP (1) JP2012528857A (es)
KR (1) KR20120039564A (es)
CN (1) CN102665685A (es)
AP (1) AP2012006053A0 (es)
AU (1) AU2010257181A1 (es)
BR (1) BRPI1010175A2 (es)
CA (1) CA2763819A1 (es)
CL (1) CL2011003049A1 (es)
CO (1) CO6511284A2 (es)
IL (1) IL216719A0 (es)
MX (1) MX2011012823A (es)
WO (1) WO2010141069A2 (es)
ZA (1) ZA201109366B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9393315B2 (en) * 2011-06-08 2016-07-19 Nitto Denko Corporation Compounds for targeting drug delivery and enhancing siRNA activity
US20120202890A1 (en) 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
WO2012122144A1 (en) * 2011-03-07 2012-09-13 Wu Nian Highly monodisperse branched peg-lipid conjugates
US10196637B2 (en) 2011-06-08 2019-02-05 Nitto Denko Corporation Retinoid-lipid drug carrier
US8883177B2 (en) * 2011-06-28 2014-11-11 Nian Wu Pharmaceutical compositions for parenteral administration
US8575380B2 (en) * 2011-10-17 2013-11-05 Nof Corporation Branched polyethylene glycol linked with diacyl glycerol, process for producing the same, and polyethylene glycol modified liposome
US11458199B2 (en) 2012-08-21 2022-10-04 Opko Pharmaceuticals, Llc Liposome formulations
KR102083700B1 (ko) 2012-08-21 2020-03-02 옵코 파마슈티칼스, 엘엘씨 리포좀 제제
SI2887923T1 (sl) * 2012-08-24 2023-09-29 Sun Pharmaceutical Industries Limited Oftalmična formulacija polioksilnega lipida ali polioksilne maščobne kisline in zdravljenje očesnih stanj
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
JP6646578B2 (ja) * 2013-12-05 2020-02-14 ウー, ニエンWU, Nian 薬物転送技術のための高分子−炭水化物共役体
CN105829886B (zh) 2013-12-20 2018-04-03 豪夫迈·罗氏有限公司 使用包含聚乙二醇部分的化合物在支持物上固定细胞的方法
CN105829887B (zh) * 2013-12-20 2019-05-10 豪夫迈·罗氏有限公司 可用于结合细胞的包含一个或多个疏水结构域和一个含有peg部分的亲水结构域的化合物
JP6461973B2 (ja) * 2013-12-20 2019-01-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ２以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む化合物の、細胞の安定化のための使用
AU2015360794B2 (en) 2014-12-08 2021-07-08 The Board Of Regents Of The University Of Texas System Lipocationic polymers and uses thereof
US10064954B2 (en) * 2015-06-23 2018-09-04 Nian Wu Polymer-cyclodextrin-lipid conjugates
PT3349802T (pt) 2015-09-14 2021-10-15 Univ Texas Dendrímeros lipocatiónicos e suas utilizações
CN106905120B (zh) * 2015-12-21 2020-04-28 北京键凯科技股份有限公司 Y型多缩乙二醇衍生物及其制备方法
NZ755442A (en) 2016-02-29 2023-04-28 Sun Pharmaceutical Ind Ltd Topical cyclosporine-containing formulations and uses thereof
JP7312552B2 (ja) 2016-05-16 2023-07-21 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム ナノ粒子としてのｔＲＮＡ送達用組成物およびその使用方法
BR112018073699A2 (pt) 2016-05-16 2019-05-07 The Board Of Regents Of The University Of Texas System amino lipídios de sulfonamida catiônica e amino lipídios zwiteriônico anfifílicos
CN111868021A (zh) * 2018-03-20 2020-10-30 日油株式会社 分枝型单分散聚乙二醇、中间体及其制备方法
JP7177392B2 (ja) * 2018-03-29 2022-11-24 日油株式会社 トリチル基含有単分散ポリエチレングリコールの精製方法
WO2019191597A1 (en) * 2018-03-30 2019-10-03 The Board Of Regents Of The University Of Oklahoma Very long chain saturated fatty acid compounds, compositions containing same, and methods of use
AU2019335055A1 (en) 2018-09-04 2021-03-25 The Board Of Regents Of The University Of Texas System Compositions and methods for organ specific delivery of nucleic acids
JP7425066B2 (ja) 2018-09-04 2024-01-30 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 核酸を臓器特異的送達するための組成物および方法
JP6805385B1 (ja) * 2020-08-31 2020-12-23 ジェイ−ネットワーク，インコーポレイテッド 表皮内の保湿関連物質の発現増強剤
JP6860739B1 (ja) * 2020-11-20 2021-04-21 ジェイ−ネットワーク，インコーポレイテッド 表皮内の抗酸化物質の発現増強剤
CN114685778B (zh) * 2020-12-30 2023-10-17 苏州艾博生物科技有限公司 长循环阳离子脂质体的合成方法
WO2022169508A1 (en) 2021-02-08 2022-08-11 The Board Of Regents Of The University Of Texas System Unsaturated dendrimers compositions,related formulations, and methods of use thereof
EP4342929A1 (en) 2021-06-30 2024-03-27 Jenkem Technology Co. Ltd. (Tianjin) Polyethylene glycol lipid and use thereof
CN113461929B (zh) * 2021-07-13 2023-04-21 浙江倍合德制药有限公司 一种tpgs系列产品的精制提纯方法
CN114507342B (zh) * 2022-03-18 2024-03-19 江苏东南纳米材料有限公司 一种1,2-二肉豆蔻酰-rac-甘油-3-甲氧基聚乙二醇及其中间体的制备方法
WO2023196445A1 (en) * 2022-04-05 2023-10-12 Capstan Therapeutics, Inc. Peg-lipids and lipid nanoparticles
CN114524943B (zh) * 2022-04-22 2022-09-16 天津凯莱英制药有限公司 聚乙二醇-甘油衍生物及其中间体各自的制备方法
CN116178733B (zh) * 2023-03-03 2023-08-01 浙江博美生物技术有限公司 一种基于三官能团氨基酸的支化单分散peg衍生物、制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US7141552B2 (en) * 2000-01-10 2006-11-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Use of lipid conjugates in the treatment of diseases
NZ592917A (en) * 2003-09-15 2012-12-21 Protiva Biotherapeutics Inc Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates
US20060051405A1 (en) * 2004-07-19 2006-03-09 Protiva Biotherapeutics, Inc. Compositions for the delivery of therapeutic agents and uses thereof
CA3218940A1 (en) * 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
CA2705797A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids

Also Published As

Publication number Publication date
CO6511284A2 (es) 2012-08-31
BRPI1010175A2 (pt) 2016-03-29
ZA201109366B (en) 2012-08-29
AP2012006053A0 (en) 2012-02-29
EP2437756A2 (en) 2012-04-11
MX2011012823A (es) 2012-06-25
KR20120039564A (ko) 2012-04-25
WO2010141069A2 (en) 2010-12-09
AU2010257181A1 (en) 2012-01-12
CA2763819A1 (en) 2010-12-09
WO2010141069A3 (en) 2012-04-12
IL216719A0 (en) 2012-02-29
US20110040113A1 (en) 2011-02-17
JP2012528857A (ja) 2012-11-15
CN102665685A (zh) 2012-09-12

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