KR20080027775A - 피롤(2,3-b)피리딘 유도체 단백질 키나제 억제제 - Google Patents
피롤(2,3-b)피리딘 유도체 단백질 키나제 억제제 Download PDFInfo
- Publication number
- KR20080027775A KR20080027775A KR1020077029428A KR20077029428A KR20080027775A KR 20080027775 A KR20080027775 A KR 20080027775A KR 1020077029428 A KR1020077029428 A KR 1020077029428A KR 20077029428 A KR20077029428 A KR 20077029428A KR 20080027775 A KR20080027775 A KR 20080027775A
- Authority
- KR
- South Korea
- Prior art keywords
- optionally substituted
- nhr
- fluoro
- group
- lower alkyl
- Prior art date
Links
- 0 C*C(**1(C)C)C(C)C1*=*=N Chemical compound C*C(**1(C)C)C(C)C1*=*=N 0.000 description 29
- CTHZFVULRMIHJC-UHFFFAOYSA-N P[n]1c2ncccc2cc1 Chemical compound P[n]1c2ncccc2cc1 CTHZFVULRMIHJC-UHFFFAOYSA-N 0.000 description 3
- MVXVYAKCVDQRLW-UHFFFAOYSA-N c1c[nH]c2ncccc12 Chemical compound c1c[nH]c2ncccc12 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 description 3
- WGQKYBSKWIADBV-UHFFFAOYSA-N NCc1ccccc1 Chemical compound NCc1ccccc1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- WGOLHUGPTDEKCF-UHFFFAOYSA-N Nc(cc1)ncc1Br Chemical compound Nc(cc1)ncc1Br WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 2
- JODIHOOIMBBKHU-UHFFFAOYSA-N O=Cc(cc1)cnc1NCc(cc1)ccc1Cl Chemical compound O=Cc(cc1)cnc1NCc(cc1)ccc1Cl JODIHOOIMBBKHU-UHFFFAOYSA-N 0.000 description 2
- VKMQVCZOMREOER-UHFFFAOYSA-N C(c1c[nH]c2ncccc12)c1ccc(NCc2ccccc2)nc1 Chemical compound C(c1c[nH]c2ncccc12)c1ccc(NCc2ccccc2)nc1 VKMQVCZOMREOER-UHFFFAOYSA-N 0.000 description 1
- VSVWWPKMHZVTNC-NHMXQFJYSA-N C/C=C(/C(C=O)=CN1P)\C1=N/C#C Chemical compound C/C=C(/C(C=O)=CN1P)\C1=N/C#C VSVWWPKMHZVTNC-NHMXQFJYSA-N 0.000 description 1
- DAMGHCDYTRBBJR-UHFFFAOYSA-N CC(C)(C)OC(N(Cc(cc1)ccc1Cl)c1ccc(C(c2c[nH]c(nc3)c2cc3Br)O)cn1)=O Chemical compound CC(C)(C)OC(N(Cc(cc1)ccc1Cl)c1ccc(C(c2c[nH]c(nc3)c2cc3Br)O)cn1)=O DAMGHCDYTRBBJR-UHFFFAOYSA-N 0.000 description 1
- ZYVRXDJHARLDFG-GTZLCMMESA-N CN/C=C\C=C1\C(C=O)=CNC1 Chemical compound CN/C=C\C=C1\C(C=O)=CNC1 ZYVRXDJHARLDFG-GTZLCMMESA-N 0.000 description 1
- OLCBSMCLARCHTH-UHFFFAOYSA-N Clc1ccc(CNc(cc2)ncc2Br)cc1 Chemical compound Clc1ccc(CNc(cc2)ncc2Br)cc1 OLCBSMCLARCHTH-UHFFFAOYSA-N 0.000 description 1
- YFVTZCWZAKUQTL-UHFFFAOYSA-N Clc1ccc(CNc2ccc(Cc(c3c4)c[nH]c3ncc4Br)cn2)cc1 Chemical compound Clc1ccc(CNc2ccc(Cc(c3c4)c[nH]c3ncc4Br)cn2)cc1 YFVTZCWZAKUQTL-UHFFFAOYSA-N 0.000 description 1
- FFTPKLAPDHKTML-UHFFFAOYSA-N O=C(c1c[nH]c2c1cccn2)c(cn1)ccc1Cl Chemical compound O=C(c1c[nH]c2c1cccn2)c(cn1)ccc1Cl FFTPKLAPDHKTML-UHFFFAOYSA-N 0.000 description 1
- AVPYQKSLYISFPO-UHFFFAOYSA-N O=Cc(cc1)ccc1Cl Chemical compound O=Cc(cc1)ccc1Cl AVPYQKSLYISFPO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68206305P | 2005-05-17 | 2005-05-17 | |
US68204205P | 2005-05-17 | 2005-05-17 | |
US68205105P | 2005-05-17 | 2005-05-17 | |
US60/682,042 | 2005-05-17 | ||
US60/682,063 | 2005-05-17 | ||
US60/682,051 | 2005-05-17 | ||
US69275005P | 2005-06-22 | 2005-06-22 | |
US69296005P | 2005-06-22 | 2005-06-22 | |
US60/692,960 | 2005-06-22 | ||
US60/692,750 | 2005-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20080027775A true KR20080027775A (ko) | 2008-03-28 |
Family
ID=37683773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020077029428A KR20080027775A (ko) | 2005-05-17 | 2006-05-16 | 피롤(2,3-b)피리딘 유도체 단백질 키나제 억제제 |
Country Status (14)
Families Citing this family (97)
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PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
CL2008001540A1 (es) * | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. |
-
2006
- 2006-05-16 BR BRPI0610066-0A patent/BRPI0610066A2/pt not_active IP Right Cessation
- 2006-05-16 KR KR1020077029428A patent/KR20080027775A/ko not_active Application Discontinuation
- 2006-05-16 EP EP06813186A patent/EP1885723A2/en not_active Withdrawn
- 2006-05-16 AU AU2006272951A patent/AU2006272951A1/en not_active Abandoned
- 2006-05-16 NZ NZ563444A patent/NZ563444A/en not_active IP Right Cessation
- 2006-05-16 CA CA002608733A patent/CA2608733A1/en not_active Abandoned
- 2006-05-16 US US11/435,381 patent/US7846941B2/en active Active
- 2006-05-16 WO PCT/US2006/018726 patent/WO2007013896A2/en active Application Filing
- 2006-05-16 MX MX2007014377A patent/MX2007014377A/es active IP Right Grant
- 2006-05-16 JP JP2008512402A patent/JP2008545652A/ja active Pending
-
2007
- 2007-11-13 IL IL187344A patent/IL187344A0/en unknown
- 2007-11-23 NO NO20075992A patent/NO20075992L/no not_active Application Discontinuation
- 2007-12-07 EC EC2007007985A patent/ECSP077985A/es unknown
- 2007-12-14 CR CR9591A patent/CR9591A/es not_active Application Discontinuation
-
2010
- 2010-12-01 US US12/958,376 patent/US20110166174A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110166174A1 (en) | 2011-07-07 |
BRPI0610066A2 (pt) | 2010-05-25 |
JP2008545652A (ja) | 2008-12-18 |
WO2007013896A2 (en) | 2007-02-01 |
ECSP077985A (es) | 2008-01-23 |
CA2608733A1 (en) | 2007-02-01 |
NZ563444A (en) | 2011-04-29 |
MX2007014377A (es) | 2008-02-06 |
EP1885723A2 (en) | 2008-02-13 |
AU2006272951A1 (en) | 2007-02-01 |
IL187344A0 (en) | 2008-04-13 |
NO20075992L (no) | 2008-02-13 |
CR9591A (es) | 2008-03-26 |
WO2007013896A3 (en) | 2007-05-31 |
US7846941B2 (en) | 2010-12-07 |
US20070032519A1 (en) | 2007-02-08 |
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