KR20080015802A - 염증 질환의 치료를 위한 리구스틸라이드 유도체 - Google Patents

염증 질환의 치료를 위한 리구스틸라이드 유도체 Download PDF

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Publication number
KR20080015802A
KR20080015802A KR1020077027212A KR20077027212A KR20080015802A KR 20080015802 A KR20080015802 A KR 20080015802A KR 1020077027212 A KR1020077027212 A KR 1020077027212A KR 20077027212 A KR20077027212 A KR 20077027212A KR 20080015802 A KR20080015802 A KR 20080015802A
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KR
South Korea
Prior art keywords
formula
compound
senkyunolide
ligustilide
inflammation
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KR1020077027212A
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English (en)
Korean (ko)
Inventor
앤 파울러
다니엘 라에데르스토르프
고에데 슐레르
요셉 슈바게르
Original Assignee
디에스엠 아이피 어셋츠 비.브이.
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Application filed by 디에스엠 아이피 어셋츠 비.브이. filed Critical 디에스엠 아이피 어셋츠 비.브이.
Publication of KR20080015802A publication Critical patent/KR20080015802A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
KR1020077027212A 2005-05-24 2006-05-24 염증 질환의 치료를 위한 리구스틸라이드 유도체 KR20080015802A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05011203 2005-05-24
EP05011203.6 2005-05-24

Publications (1)

Publication Number Publication Date
KR20080015802A true KR20080015802A (ko) 2008-02-20

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KR1020077027212A KR20080015802A (ko) 2005-05-24 2006-05-24 염증 질환의 치료를 위한 리구스틸라이드 유도체

Country Status (8)

Country Link
US (2) US20090176873A1 (zh)
EP (1) EP1937250B1 (zh)
JP (1) JP2008542226A (zh)
KR (1) KR20080015802A (zh)
CN (1) CN101184484B (zh)
AT (1) ATE529107T1 (zh)
ES (1) ES2375302T3 (zh)
WO (1) WO2006125651A2 (zh)

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KR20090033470A (ko) * 2006-07-14 2009-04-03 디에스엠 아이피 어셋츠 비.브이. 로즈힙 및 다른 활성 약품을 포함하는, 염증성 질환의 치료를 위한 조성물
WO2008006582A1 (en) * 2006-07-14 2008-01-17 Dsm Ip Assets B.V. Compositions comprising magnolol or honokiol and other active agents for the treatment of inflammatory diseases
EP2040696B1 (en) * 2006-07-14 2017-01-25 DSM IP Assets B.V. Compositions and use thereof for the treatment, co-treatment or prevention of inflammatory disorders
CN101991568B (zh) * 2009-08-12 2012-02-08 上海张江中药现代制剂技术工程研究中心 洋川芎内酯i在制备抗抑郁症药物、偏头痛药物及其他5-羟色胺能系统相关疾病药物中的应用
CN102844027A (zh) * 2009-11-23 2012-12-26 培力(香港)健康产品有限公司 治疗炎症和免疫系统障碍的新治疗方法
CN106074497A (zh) * 2010-01-13 2016-11-09 石药集团恩必普药业有限公司 丁苯酞及其衍生物在制备治疗帕金森病的药物中的应用
US8927601B2 (en) * 2011-12-20 2015-01-06 National Dong Hwa University Uses of N-butylidenephthalide in treating a liver injury and improving liver function
TWI460168B (zh) * 2012-08-10 2014-11-11 Univ China Medical 用於抑制運動神經元自體吞噬之醫藥組合物及其應用
BR112015001989B1 (pt) * 2012-08-17 2022-06-14 China Medical University Uso de butilidenoftalida (bp)
CN102793696B (zh) * 2012-08-31 2014-09-10 甘肃中医学院 丁苯酞在制备治疗支气管哮喘药物中的应用
TWI487521B (zh) * 2013-03-12 2015-06-11 Hawking Biolog Technology Co Ltd 苯酞化合物之應用
US20140271568A1 (en) 2013-03-12 2014-09-18 Hawking Biological Technology Co., Ltd Method and kit for providing an increased expression of telomerase, brain-derived neurotrophic factor, stromal cell-derived factor-1, cxc chemokine receptor 4, and/or immune regulatory factor of stem cell
TWI511727B (zh) 2014-07-02 2015-12-11 Everfront Biotech Inc 苯酞化合物之應用
EP3175851B1 (en) * 2014-07-28 2021-08-18 Everfront Biotech Inc. Use of butenylphthalide, usage method thereof and method for preparing same into pharmaceutical composition
CN105311014A (zh) * 2014-07-28 2016-02-10 李德财 丁烯基苯酞的用途及将其制备为医药组合物的方法
WO2016037587A1 (en) * 2014-09-11 2016-03-17 Taiwan Mitochondrion Applied Technology Co., Ltd Pharmaceutical compositions for treating degenerative neurological disease with mitocells
JP6718522B2 (ja) * 2016-05-19 2020-07-08 長弘生物科技股▲ふん▼有限公司 肺線維症の発症および／または治療の遅延のための医薬製剤
US10688128B2 (en) * 2016-05-23 2020-06-23 Everfront Biotech Inc. Use of Z-butylidenephthalide in activating autoimmune system
CN106432161A (zh) * 2016-07-19 2017-02-22 四川大学 一类3‑烃基‑5,6‑二氧取代苯酞化合物及其制备方法和用途
CN107669689B (zh) * 2017-11-07 2021-04-30 浙江大学 一种治疗慢性阻塞性肺病的气雾剂
CN109350620B (zh) * 2018-12-15 2019-08-06 谭志军 一种治疗卵巢癌的药物及其用途
CN109498617A (zh) * 2018-12-26 2019-03-22 南京中医药大学 藁本内酯在制备防治骨质疏松症药品中的应用
CN111617071B (zh) * 2019-02-27 2023-05-23 苏州凯祥生物科技有限公司 一种高尿酸血症药物组合物及用于治疗高尿酸血症的药物
CN109966288A (zh) * 2019-05-05 2019-07-05 嘉兴市第二医院 一种治疗或预防动脉粥样硬化药物及应用
CN110169965B (zh) * 2019-05-28 2021-10-08 江苏康缘药业股份有限公司 一种化合物在治疗软骨退变性疾病方面的应用
CN114209691A (zh) * 2022-01-06 2022-03-22 正大青春宝药业有限公司 一种洋川芎内酯i复合物及在治疗心肌肥大疾病中的应用

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Also Published As

Publication number Publication date
EP1937250B1 (en) 2011-10-19
US20090176873A1 (en) 2009-07-09
ATE529107T1 (de) 2011-11-15
CN101184484A (zh) 2008-05-21
US20100298427A1 (en) 2010-11-25
WO2006125651A3 (en) 2007-07-19
ES2375302T3 (es) 2012-02-28
EP1937250A2 (en) 2008-07-02
CN101184484B (zh) 2011-10-05
JP2008542226A (ja) 2008-11-27
WO2006125651A2 (en) 2006-11-30

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