KR20070100820A - 경피 흡수 제제, 경피 흡수 제제 유지 시트 및 경피 흡수제제 유지 용구 - Google Patents
경피 흡수 제제, 경피 흡수 제제 유지 시트 및 경피 흡수제제 유지 용구 Download PDFInfo
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- KR20070100820A KR20070100820A KR1020077019775A KR20077019775A KR20070100820A KR 20070100820 A KR20070100820 A KR 20070100820A KR 1020077019775 A KR1020077019775 A KR 1020077019775A KR 20077019775 A KR20077019775 A KR 20077019775A KR 20070100820 A KR20070100820 A KR 20070100820A
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- South Korea
- Prior art keywords
- transdermal
- preparation
- base
- skin
- absorbent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- Diabetes (AREA)
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| JPJP-P-2005-00023276 | 2005-01-31 | ||
| JPJP-P-2005-00296691 | 2005-10-11 | ||
| JP2005296691 | 2005-10-11 |
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Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080262444A1 (enExample) |
| EP (1) | EP1844763B2 (enExample) |
| JP (2) | JP4913030B2 (enExample) |
| KR (1) | KR20070100820A (enExample) |
| AU (1) | AU2006209421A1 (enExample) |
| CA (1) | CA2595894C (enExample) |
| WO (1) | WO2006080508A1 (enExample) |
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| KR20160125420A (ko) * | 2014-03-12 | 2016-10-31 | 가부시키가이샤 바이오세렌택 | 진피 내 목적 물질 유치용 마이크로니들 제제 투여 부재 및 마이크로니들 제제 신속 투여 기구 |
| KR20180121537A (ko) * | 2016-03-16 | 2018-11-07 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 푸코이단 육모제 |
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Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6445933A (en) * | 1987-08-12 | 1989-02-20 | Nissan Motor | Control device in internal combustion engine with automatic gear |
| JP4913030B2 (ja) | 2005-01-31 | 2012-04-11 | 株式会社バイオセレンタック | 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具 |
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| JP2011012050A (ja) * | 2009-06-03 | 2011-01-20 | Bioserentack Co Ltd | 多孔性基盤を用いたマイクロニードル・アレイとその製造方法 |
| US8834423B2 (en) | 2009-10-23 | 2014-09-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Dissolvable microneedle arrays for transdermal delivery to human skin |
| EP2528540A4 (en) * | 2010-01-29 | 2013-11-13 | Icon Medical Corp | BIODEGRADABLE LEAKS ON AN INFLATABLE DEVICE |
| US8911422B2 (en) | 2010-02-24 | 2014-12-16 | Hisamitsu Pharmaceutical Co., Inc. | Micro-needle device |
| JP5800799B2 (ja) * | 2010-03-19 | 2015-10-28 | コスメディ製薬株式会社 | プロテオグリカンを含有するマイクロニードルアレイ |
| AU2011248108B2 (en) | 2010-05-04 | 2016-05-26 | Corium Pharma Solutions, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
| JP5808102B2 (ja) * | 2010-07-22 | 2015-11-10 | コスメディ製薬株式会社 | 抗原を含有する経皮免疫製剤およびその製造方法 |
| JP5672554B2 (ja) * | 2010-08-19 | 2015-02-18 | Ｊｃｒファーマ株式会社 | 皮下又は経皮吸収用組成物 |
| US10933173B2 (en) | 2010-10-19 | 2021-03-02 | Trustees Of Tufts College | Silk fibroin-based microneedles and methods of making the same |
| US20130309218A1 (en) * | 2011-01-31 | 2013-11-21 | Wacker Chemie Ag | Process for producing aqueous solution containing fat-soluble substance |
| JP5977675B2 (ja) * | 2011-06-28 | 2016-08-24 | 株式会社バイオセレンタック | 皮膚治療用微細針集積型製剤 |
| JP2013162861A (ja) * | 2012-02-10 | 2013-08-22 | Bioserentack Co Ltd | 細胞間液モニター用マイクロニードル |
| JP6277953B2 (ja) * | 2012-02-29 | 2018-02-14 | 凸版印刷株式会社 | 針状体の製造方法 |
| CN112933391A (zh) | 2012-05-01 | 2021-06-11 | 高等教育联邦系统-匹兹堡大学 | 用于经皮插入的尖端负载的微针阵列 |
| JP6546091B2 (ja) | 2012-09-13 | 2019-07-17 | アミール，アブラハム | 皮膚増大（ｓｋｉｎａｕｇｍｅｎｔａｔｉｏｎ）のための送達デバイスおよび方法 |
| US12161831B2 (en) | 2012-09-13 | 2024-12-10 | Avraham Amir | Microneedles and compositions for skin augmentation |
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| CA2896188C (en) | 2012-12-21 | 2021-02-23 | Corium International, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| EP2946805A4 (en) * | 2013-01-21 | 2016-10-26 | Bukyoung Pharm Co Ltd | MICRONADEL, FORM FOR THE PRODUCTION THEREOF AND METHOD OF MANUFACTURING THEREOF |
| US20140243763A1 (en) * | 2013-02-25 | 2014-08-28 | Sara Heikali | Devices for the Placement of Medical Compounds in Natural Orifices of a Body |
| US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
| ITMI20130586A1 (it) * | 2013-04-11 | 2014-10-12 | Azienda Ospedaliero Universitaria P Isana | Microago e matrice di microaghi per uso medicale, e processo di produzione di detta matrice |
| GB201307262D0 (en) * | 2013-04-23 | 2013-05-29 | Chowdhury Dewan F H | Device for containment and release of drug formulation |
| JP5806701B2 (ja) * | 2013-05-07 | 2015-11-10 | 日本写真印刷株式会社 | 経皮投与用貼付剤の製造方法及び経皮投与用貼付剤 |
| EP3006047B1 (en) * | 2013-06-06 | 2019-08-07 | Toppan Printing Co., Ltd. | Needle body |
| US10500386B2 (en) | 2013-07-30 | 2019-12-10 | Asti Corporation | Microneedle array manufacturing method |
| US20150141910A1 (en) * | 2013-11-14 | 2015-05-21 | University Medical Pharmaceuticals Corporation | Microneedles for therapeutic agent delivery with improved mechanical properties |
| JP5931110B2 (ja) * | 2014-03-26 | 2016-06-08 | 日本写真印刷株式会社 | 錐体状突起シートの梱包体の製造方法 |
| WO2016017439A1 (ja) | 2014-07-30 | 2016-02-04 | 凸版印刷株式会社 | マイクロニードルユニット |
| MA41048A (fr) * | 2014-10-07 | 2017-08-15 | Qualyst Transp Solutions Llc | Utilité d'une protéine dans la prédiction d'effets in vivo |
| JP6317690B2 (ja) | 2015-03-03 | 2018-04-25 | 富士フイルム株式会社 | 経皮吸収シート、及びその製造方法 |
| JP6482323B2 (ja) | 2015-03-03 | 2019-03-13 | 富士フイルム株式会社 | 経皮吸収シート |
| WO2016149673A1 (en) | 2015-03-18 | 2016-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Bioactive components conjugated to substrates of microneedle arrays |
| CN107427474A (zh) * | 2015-04-13 | 2017-12-01 | 株式会社Lg生活健康 | 含有调节神经递质释放的成分的可溶性微针 |
| US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
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| WO2017018086A1 (ja) * | 2015-07-29 | 2017-02-02 | 日本写真印刷株式会社 | マイクロニードルシート |
| WO2017066768A1 (en) | 2015-10-16 | 2017-04-20 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices |
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| US11744889B2 (en) | 2016-01-05 | 2023-09-05 | University of Pittsburgh—of the Commonwealth System of Higher Education | Skin microenvironment targeted delivery for promoting immune and other responses |
| CN110917176B (zh) * | 2018-08-31 | 2021-03-30 | 中科微针（北京）科技有限公司 | 一种可植入型缓释微针贴片及其制备方法 |
| KR102175312B1 (ko) * | 2018-10-08 | 2020-11-06 | 연세대학교 산학협력단 | 마이크로 구조체 |
| CN113727751B (zh) * | 2019-04-02 | 2024-03-15 | 宝龄富锦生技股份有限公司 | 微针装置及其制法 |
| AU2020275934B2 (en) | 2019-05-16 | 2025-09-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery |
| US20260014359A1 (en) * | 2022-06-30 | 2026-01-15 | Lintec Corporation | Microneedle structure |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4774091A (en) | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
| US4754745A (en) * | 1984-11-21 | 1988-07-05 | Horowitz Bruce S | Conformable sheet material for use in brachytherapy |
| US5582591A (en) * | 1994-09-02 | 1996-12-10 | Delab | Delivery of solid drug compositions |
| US5837276A (en) * | 1994-09-02 | 1998-11-17 | Delab | Apparatus for the delivery of elongate solid drug compositions |
| US5542920A (en) | 1994-09-12 | 1996-08-06 | Delab | Needle-less parenteral introduction device |
| JP3001381B2 (ja) | 1994-09-16 | 2000-01-24 | 株式会社ディ・ディ・エス研究所 | 臓器移行性を有する多糖誘導体および薬物担体 |
| JP3699141B2 (ja) | 1994-09-24 | 2005-09-28 | 伸彦 由井 | 超分子構造の生体内分解性医薬高分子集合体及びその調製方法 |
| JP3536186B2 (ja) | 1995-02-27 | 2004-06-07 | 独立行政法人 科学技術振興機構 | 生体内分解性高分子ヒドロゲル |
| JP3538741B2 (ja) | 1995-05-23 | 2004-06-14 | 独立行政法人 科学技術振興機構 | 複合刺激応答型生体内分解性高分子ヒドロゲル |
| TW487582B (en) | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| JP3832970B2 (ja) | 1998-05-11 | 2006-10-11 | 独立行政法人科学技術振興機構 | 温度応答型生体内分解性高分子 |
| JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| IL131074A0 (en) | 1999-07-23 | 2001-03-19 | Polygene Ltd | A biodegradable polycation composition for delivery of an anionic macromolecule |
| CA2396767A1 (en) * | 1999-12-30 | 2001-07-12 | Redeon, Inc. | Stacked microneedle systems |
| FR2809112B1 (fr) | 2000-05-16 | 2004-05-07 | Centre Nat Rech Scient | Materiaux a base de polymeres biodegradables et son procede de preparation |
| GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
| JP2006500115A (ja) * | 2000-11-16 | 2006-01-05 | マイクロスフエリツクス・エル・エル・シー | 密封小線源治療用の可撓性および／または弾性シードまたはストランド |
| US6746661B2 (en) * | 2000-11-16 | 2004-06-08 | Microspherix Llc | Brachytherapy seed |
| US6638246B1 (en) * | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
| WO2002064193A2 (en) * | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| TWI259836B (en) | 2001-04-12 | 2006-08-11 | Astrazeneca Ab | Modified release formulation suitable for antiarrhythmic compounds |
| WO2002083232A1 (en) * | 2001-04-13 | 2002-10-24 | Becton, Dickinson And Company | Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption |
| US6767341B2 (en) * | 2001-06-13 | 2004-07-27 | Abbott Laboratories | Microneedles for minimally invasive drug delivery |
| CA2500453A1 (en) * | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Microneedle with membrane |
| JP4090018B2 (ja) * | 2002-02-18 | 2008-05-28 | Ｆｏｒ Ｈｅａｄ株式会社 | 機能性マイクロパイル及びその製造方法 |
| KR101061975B1 (ko) | 2002-06-25 | 2011-09-05 | 권성윤 | 약물 송달 및 다른 용도를 위한 신속 용해형 마이크로 퍼포레이터를 포함하는 어레이 |
| JP2004081739A (ja) | 2002-08-29 | 2004-03-18 | Mitsuru Akashi | ハイドロキシアパタイト−ポリマー複合材料の止血用組成物 |
| WO2004033021A1 (en) * | 2002-10-07 | 2004-04-22 | Biovalve Technologies, Inc. | Microneedle array patch |
| JP2004277325A (ja) * | 2003-03-14 | 2004-10-07 | Intorasu Ltd | 皮膚吸収による物質のデリバリ方法、皮膚吸収による物質のデリバリに用いるピーリング剤、ピーリング装置、ならびにピーリング装置用ディスポーザブルパッド |
| JP2005023276A (ja) | 2003-07-03 | 2005-01-27 | Nippon Purai Kk | ウインドモール用接着フィルム |
| EP1677687A4 (en) * | 2003-10-28 | 2008-09-17 | Alza Corp | ADMINISTRATION OF POLYMERIC CONJUGATES OF PEPTIDES AND THERAPEUTIC PROTEINS THROUGH COATED MICROPROTUBERANCES |
| JP2005152180A (ja) * | 2003-11-25 | 2005-06-16 | Nano Device & System Research Inc | インスリン投与用マイクロニードル |
| JP2005154321A (ja) * | 2003-11-25 | 2005-06-16 | Nano Device & System Research Inc | アスコルビン酸投与用マイクロニードル |
| US7361182B2 (en) | 2003-12-19 | 2008-04-22 | Lightnix, Inc. | Medical lancet |
| JP4210231B2 (ja) | 2004-03-25 | 2009-01-14 | 株式会社資生堂 | 皮膚のシワを改善する美容方法及びシワ改善具 |
| US7591806B2 (en) * | 2004-05-18 | 2009-09-22 | Bai Xu | High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances |
| JP4913030B2 (ja) | 2005-01-31 | 2012-04-11 | 株式会社バイオセレンタック | 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具 |
| JP2005296691A (ja) | 2005-07-13 | 2005-10-27 | Aruze Corp | 遊技機 |
| US20090099502A1 (en) * | 2006-04-07 | 2009-04-16 | Hisamitsu Pharmaceutical Co., Inc. | Microneedle Device And Transdermal Administration Device Provided With Microneedles |
-
2006
- 2006-01-30 JP JP2007500638A patent/JP4913030B2/ja not_active Expired - Lifetime
- 2006-01-30 KR KR1020077019775A patent/KR20070100820A/ko not_active Ceased
- 2006-01-30 AU AU2006209421A patent/AU2006209421A1/en not_active Abandoned
- 2006-01-30 EP EP06712623.5A patent/EP1844763B2/en not_active Expired - Lifetime
- 2006-01-30 CA CA2595894A patent/CA2595894C/en not_active Expired - Fee Related
- 2006-01-30 US US11/883,118 patent/US20080262444A1/en not_active Abandoned
- 2006-01-30 WO PCT/JP2006/301480 patent/WO2006080508A1/ja not_active Ceased
-
2009
- 2009-02-09 JP JP2009027351A patent/JP4800399B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-28 US US12/914,456 patent/US8506980B2/en not_active Expired - Fee Related
Cited By (5)
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|---|---|---|---|---|
| KR101224939B1 (ko) * | 2009-12-07 | 2013-01-22 | 가천대학교 산학협력단 | 활성 성분의 흡수 속도가 개선된 마이크로니들 |
| KR20160125420A (ko) * | 2014-03-12 | 2016-10-31 | 가부시키가이샤 바이오세렌택 | 진피 내 목적 물질 유치용 마이크로니들 제제 투여 부재 및 마이크로니들 제제 신속 투여 기구 |
| KR20180121537A (ko) * | 2016-03-16 | 2018-11-07 | 코스메드 파마소티컬 씨오 쩜 엘티디 | 푸코이단 육모제 |
| KR102685131B1 (ko) * | 2023-10-25 | 2024-07-15 | 주식회사 스몰랩 | 안정성이 증진된 리라글루타이드-함유 마이크로니들용 조성물 및 이의 이용 |
| WO2025089491A1 (ko) * | 2023-10-25 | 2025-05-01 | 주식회사 스몰랩 | 안정성이 증진된 리라글루타이드-함유 마이크로니들용 조성물 및 이의 이용 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2595894C (en) | 2013-09-10 |
| EP1844763A1 (en) | 2007-10-17 |
| WO2006080508A1 (ja) | 2006-08-03 |
| AU2006209421A1 (en) | 2006-08-03 |
| EP1844763A4 (en) | 2010-08-18 |
| JP4800399B2 (ja) | 2011-10-26 |
| JP2009138010A (ja) | 2009-06-25 |
| US20110046575A1 (en) | 2011-02-24 |
| JP4913030B2 (ja) | 2012-04-11 |
| US8506980B2 (en) | 2013-08-13 |
| EP1844763B1 (en) | 2018-08-08 |
| US20080262444A1 (en) | 2008-10-23 |
| EP1844763B2 (en) | 2022-09-07 |
| JPWO2006080508A1 (ja) | 2008-06-19 |
| CA2595894A1 (en) | 2006-08-03 |
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