KR20070030261A - 3-알케닐세펨 화합물의 제조 방법 - Google Patents
3-알케닐세펨 화합물의 제조 방법 Download PDFInfo
- Publication number
- KR20070030261A KR20070030261A KR1020077000096A KR20077000096A KR20070030261A KR 20070030261 A KR20070030261 A KR 20070030261A KR 1020077000096 A KR1020077000096 A KR 1020077000096A KR 20077000096 A KR20077000096 A KR 20077000096A KR 20070030261 A KR20070030261 A KR 20070030261A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- alkali metal
- carboxylic acid
- methylthiazol
- vinyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (8)
- 제1항에 있어서, 고다공성 중합체 및/또는 활성탄으로의 처리를 교반하에서 행하는 제조 방법.
- 화학식 3으로 표시되는 7-치환 아실아미노-3-[(E/Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산 화합물에 4 위치 카르복실산 보호기의 탈보호 반응을 행하고, 알칼리 금속 수산화물, 알칼리 금속 탄산수소염, 및 알칼리 금속 탄산염으로부터 선택되는 화합물의 1종 이상의 수용액으로 처리하여 화학식 4의 7-치환 아실아미노-3-[(E/Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산의 알칼리 금속염을 얻은 후, 수용액 중에서 효소 반응을 실시하여 얻어지는 화학식 1의 7-아미노-3-[(E/Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산의 알칼리 금속염의 수용액에 고다공성 중합체 및/또는 활성탄을 첨가하여 처리하는 것을 특징으로 하는 화학식 2로 표시되는 7-아미노-3-[(Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산 및 그의 알칼리 금속염의 함유율이 향상된 화학식 1로 표시되는 7-아미노-3-[(E/Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산 및 그의 알칼리 금속염의 제조 방법.<화학식 3>식 중, R1은 벤질기 또는 페녹시메틸기를 나타내고, R2는 카르복실산 보호기를 나타낸다.<화학식 4>식 중, R1은 상기와 동일하고, M은 알칼리 금속을 나타낸다.
- 제3항에 있어서, 고다공성 중합체 및/또는 활성탄으로의 처리를 교반하에서 행하는 제조 방법.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 고다공성 중합체가 아크릴계 수지, 페놀계 수지, 스티렌계 수지를 모체 구조로 하는, 비표면적 400 ㎡/g 이상의 중합체인 제조 방법.
- 제1항 또는 제3항에 있어서, 처리 후의 7-아미노-3-[(Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산 및 그의 알칼리 금속염의 함유율이 99% 이상인 제조 방법.
- 제6항에 있어서, 처리 후의 7-아미노-3-[(Z)-2-(4-메틸티아졸-5-일)비닐]-3-세펨-4-카르복실산 및 그의 알칼리 금속염의 함유율이 99.5% 이상인 제조 방법.
- 제3항에 있어서, 효소 반응을 페니실린-G 아실라아제 효소를 이용하여 반응 온도 10 내지 50 ℃, pH 7.0 내지 9.5의 범위에서 행하는 제조 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2004-00167581 | 2004-06-04 | ||
JP2004167581A JP4046708B2 (ja) | 2004-06-04 | 2004-06-04 | 3−アルケニルセフェム化合物の製造方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020087021768A Division KR100882067B1 (ko) | 2004-06-04 | 2005-06-03 | 3-알케닐세펨 화합물의 제조 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20070030261A true KR20070030261A (ko) | 2007-03-15 |
KR100870804B1 KR100870804B1 (ko) | 2008-11-27 |
Family
ID=35462876
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020087021768A KR100882067B1 (ko) | 2004-06-04 | 2005-06-03 | 3-알케닐세펨 화합물의 제조 방법 |
KR1020077000096A KR100870804B1 (ko) | 2004-06-04 | 2005-06-03 | 3-알케닐세펨 화합물의 제조 방법 |
Family Applications Before (1)
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KR1020087021768A KR100882067B1 (ko) | 2004-06-04 | 2005-06-03 | 3-알케닐세펨 화합물의 제조 방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US7893254B2 (ko) |
EP (1) | EP1752459B1 (ko) |
JP (1) | JP4046708B2 (ko) |
KR (2) | KR100882067B1 (ko) |
CN (1) | CN1964981B (ko) |
ES (1) | ES2632500T3 (ko) |
HK (1) | HK1105968A1 (ko) |
WO (1) | WO2005118595A1 (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US7459550B2 (en) * | 2003-07-04 | 2008-12-02 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of Cefditoren |
JP4064948B2 (ja) * | 2004-06-04 | 2008-03-19 | 明治製菓株式会社 | 3−アルケニルセフェム化合物及び製造方法 |
JP4659074B2 (ja) * | 2008-07-15 | 2011-03-30 | 日本化学工業株式会社 | 3−アルケニルセフェム化合物の製造方法 |
CN101735248A (zh) * | 2008-11-07 | 2010-06-16 | 日本化学工业株式会社 | 3-链烯基头孢烯化合物的制造方法 |
KR101618874B1 (ko) * | 2008-11-07 | 2016-05-09 | 니폰 가가쿠 고교 가부시키가이샤 | 3-알케닐세펨 화합물의 제조 방법 |
JPWO2011093294A1 (ja) * | 2010-01-27 | 2013-06-06 | 日本化学工業株式会社 | セファロスポリン誘導体の製造方法 |
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-
2004
- 2004-06-04 JP JP2004167581A patent/JP4046708B2/ja not_active Expired - Lifetime
-
2005
- 2005-06-03 EP EP05751538.9A patent/EP1752459B1/en active Active
- 2005-06-03 CN CN2005800177369A patent/CN1964981B/zh active Active
- 2005-06-03 US US11/628,248 patent/US7893254B2/en active Active
- 2005-06-03 ES ES05751538.9T patent/ES2632500T3/es active Active
- 2005-06-03 KR KR1020087021768A patent/KR100882067B1/ko active IP Right Grant
- 2005-06-03 WO PCT/JP2005/010621 patent/WO2005118595A1/ja active Application Filing
- 2005-06-03 KR KR1020077000096A patent/KR100870804B1/ko active IP Right Grant
-
2007
- 2007-10-18 HK HK07111290.7A patent/HK1105968A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1752459A1 (en) | 2007-02-14 |
US7893254B2 (en) | 2011-02-22 |
KR100882067B1 (ko) | 2009-02-10 |
CN1964981A (zh) | 2007-05-16 |
JP2005343854A (ja) | 2005-12-15 |
ES2632500T3 (es) | 2017-09-13 |
HK1105968A1 (en) | 2008-02-29 |
EP1752459A4 (en) | 2008-01-02 |
US20080033166A1 (en) | 2008-02-07 |
EP1752459B1 (en) | 2017-05-10 |
KR100870804B1 (ko) | 2008-11-27 |
JP4046708B2 (ja) | 2008-02-13 |
CN1964981B (zh) | 2011-08-17 |
WO2005118595A1 (ja) | 2005-12-15 |
KR20080086554A (ko) | 2008-09-25 |
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