KR20020064283A - 세포외 기록용 일체화 복합 전극 - Google Patents
세포외 기록용 일체화 복합 전극 Download PDFInfo
- Publication number
- KR20020064283A KR20020064283A KR1020027003248A KR20027003248A KR20020064283A KR 20020064283 A KR20020064283 A KR 20020064283A KR 1020027003248 A KR1020027003248 A KR 1020027003248A KR 20027003248 A KR20027003248 A KR 20027003248A KR 20020064283 A KR20020064283 A KR 20020064283A
- Authority
- KR
- South Korea
- Prior art keywords
- region
- electrode
- cell
- integrated composite
- composite electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 67
- 238000005259 measurement Methods 0.000 claims abstract description 31
- 230000000638 stimulation Effects 0.000 claims abstract description 29
- 239000012472 biological sample Substances 0.000 claims abstract description 23
- 239000000758 substrate Substances 0.000 claims abstract description 23
- 230000002093 peripheral effect Effects 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 9
- 239000011159 matrix material Substances 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 9
- 238000004113 cell culture Methods 0.000 claims description 6
- 230000003287 optical effect Effects 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 description 62
- 210000002569 neuron Anatomy 0.000 description 19
- 238000010586 diagram Methods 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 9
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 8
- 210000004556 brain Anatomy 0.000 description 6
- 230000036982 action potential Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 239000004642 Polyimide Substances 0.000 description 4
- 210000005056 cell body Anatomy 0.000 description 4
- 239000007772 electrode material Substances 0.000 description 4
- 230000000971 hippocampal effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920001721 polyimide Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000004793 Polystyrene Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- AMGQUBHHOARCQH-UHFFFAOYSA-N indium;oxotin Chemical compound [In].[Sn]=O AMGQUBHHOARCQH-UHFFFAOYSA-N 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- -1 quartz Chemical compound 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 2
- 229910001887 tin oxide Inorganic materials 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 210000003050 axon Anatomy 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000007877 drug screening Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000010220 ion permeability Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000005355 lead glass Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000007261 regionalization Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000213531A JP3909738B2 (ja) | 2000-07-13 | 2000-07-13 | 細胞外記録用一体化複合電極 |
| JPJP-P-2000-00213531 | 2000-07-13 | ||
| PCT/JP2001/006067 WO2002006809A1 (en) | 2000-07-13 | 2001-07-12 | Extracellular recording integrated composite electrode |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20020064283A true KR20020064283A (ko) | 2002-08-07 |
Family
ID=18709271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020027003248A Ceased KR20020064283A (ko) | 2000-07-13 | 2001-07-12 | 세포외 기록용 일체화 복합 전극 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6894511B2 (https=) |
| EP (1) | EP1300678B1 (https=) |
| JP (1) | JP3909738B2 (https=) |
| KR (1) | KR20020064283A (https=) |
| CN (1) | CN1190665C (https=) |
| CA (1) | CA2377813C (https=) |
| DE (1) | DE60124716T2 (https=) |
| TW (1) | TW541433B (https=) |
| WO (1) | WO2002006809A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010041794A1 (en) * | 2008-10-08 | 2010-04-15 | Korea Institute Of Science And Technology | A flexible, multi-channel microelectrode for recording laboratory animal eeg and method for recording laboratory animal eeg using the same |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7136696B2 (en) | 2002-04-05 | 2006-11-14 | The Cleveland Clinic Foundation | Neuron signal analysis system and method |
| AU2003233449B2 (en) * | 2002-08-06 | 2009-07-02 | The Regents Of The University Of California | Tear film osmometry |
| US8020433B2 (en) * | 2003-03-25 | 2011-09-20 | Tearlab Research, Inc. | Systems and methods for a sample fluid collection device |
| US7810380B2 (en) | 2003-03-25 | 2010-10-12 | Tearlab Research, Inc. | Systems and methods for collecting tear film and measuring tear film osmolarity |
| US7905134B2 (en) * | 2002-08-06 | 2011-03-15 | The Regents Of The University Of California | Biomarker normalization |
| WO2005098673A1 (ja) | 2004-04-09 | 2005-10-20 | Sony Corporation | 嗜好情報収集システム，装置，方法及びプログラム |
| US20050256541A1 (en) * | 2004-04-30 | 2005-11-17 | Medtronic, Inc. | Catheter with temporary stimulation electrode |
| JP4604176B2 (ja) * | 2004-08-17 | 2010-12-22 | 独立行政法人産業技術総合研究所 | 表面電位測定型センサー装置 |
| KR100823117B1 (ko) | 2006-08-23 | 2008-04-18 | 부산대학교 산학협력단 | 이온 선택성 미소전극의 전위 측정 장치 |
| JP4928402B2 (ja) * | 2007-09-27 | 2012-05-09 | 日本電信電話株式会社 | 電気的活動刺激計測方法および電気的活動刺激計測装置 |
| CA2723223C (en) * | 2008-05-05 | 2017-06-06 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
| CN103454314B (zh) * | 2013-09-02 | 2016-08-31 | 中国人民解放军第三军医大学 | 一种电生理综合实验屏蔽盒 |
| CN106716116B (zh) | 2014-09-23 | 2021-04-27 | 蒂尔实验室研究有限公司 | 用于微流体泪液收集和感兴趣的分析物的横向流动分析的集成的系统和方法 |
| JP6853180B2 (ja) | 2015-10-09 | 2021-03-31 | ソニーセミコンダクタソリューションズ株式会社 | 電位測定装置 |
| WO2017221714A1 (ja) | 2016-06-21 | 2017-12-28 | ソニー株式会社 | 半導体装置および細胞電位測定装置 |
| WO2018101076A1 (ja) | 2016-12-02 | 2018-06-07 | ソニーセミコンダクタソリューションズ株式会社 | 半導体装置、および電位測定装置 |
| CN110023746B (zh) | 2016-12-02 | 2022-11-18 | 索尼半导体解决方案公司 | 半导体装置和电位测量装置 |
| US11606071B2 (en) | 2017-10-23 | 2023-03-14 | Sony Semiconductor Solutions Corporation | Semiconductor device and potential measurement apparatus |
| US10736536B2 (en) * | 2018-01-12 | 2020-08-11 | NovaScan, Inc. | Techniques for predicting recurrence of cancerous cells using impedance detection |
| WO2019176489A1 (ja) * | 2018-03-13 | 2019-09-19 | パナソニックＩｐマネジメント株式会社 | 電気反応計測装置、電気反応処理方法及びプログラム |
| JP2019219244A (ja) * | 2018-06-19 | 2019-12-26 | ソニーセミコンダクタソリューションズ株式会社 | 電位測定装置及び電位測定装置の製造方法 |
| JP2020153778A (ja) | 2019-03-19 | 2020-09-24 | ソニーセミコンダクタソリューションズ株式会社 | 電位測定装置 |
| JP7229110B2 (ja) * | 2019-06-25 | 2023-02-27 | 株式会社Ｓｃｒｅｅｎホールディングス | 細胞電位測定装置 |
| JP7469092B2 (ja) | 2020-03-23 | 2024-04-16 | 株式会社Ｓｃｒｅｅｎホールディングス | 細胞保持容器 |
| CN116018674A (zh) | 2020-09-07 | 2023-04-25 | 索尼半导体解决方案公司 | 电位测量装置 |
| JP7705763B2 (ja) * | 2021-09-15 | 2025-07-10 | 株式会社Ｓｃｒｅｅｎホールディングス | 細胞外電位計測プレート |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2949845B2 (ja) | 1990-11-30 | 1999-09-20 | 松下電器産業株式会社 | 細胞電気活動計測用電極 |
| DE69333945T2 (de) | 1992-09-04 | 2006-06-29 | Matsushita Electric Industrial Co., Ltd., Kadoma | Flache Elektrode |
| US5810725A (en) * | 1993-04-16 | 1998-09-22 | Matsushita Electric Industrial Co., Ltd. | Planar electrode |
| US5563067A (en) | 1994-06-13 | 1996-10-08 | Matsushita Electric Industrial Co., Ltd. | Cell potential measurement apparatus having a plurality of microelectrodes |
| WO1998022819A1 (de) * | 1996-11-16 | 1998-05-28 | Nmi Naturwissenschaftliches Und Medizinisches Institut An Der Universität Tübingen In Reutlingen Stiftung Bürgerlichen Rechts | Mikroelementenanordnung, verfahren zum kontaktieren von in einer flüssigen umgebung befindlichen zellen und verfahren zum herstellen einer mikroelementenanordnung |
| US5981268A (en) * | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
| JPH11187865A (ja) * | 1997-12-25 | 1999-07-13 | Matsushita Electric Ind Co Ltd | 細胞電位測定電極及びこれを用いた測定装置 |
| DE19827957C2 (de) * | 1998-05-27 | 2000-06-29 | Micronas Intermetall Gmbh | Verfahren und Vorrichtung zur Messung einer Zustandsgröße |
| JP4017058B2 (ja) * | 1999-05-31 | 2007-12-05 | 誠 石田 | プローブおよびこれを備えたセンサ |
-
2000
- 2000-07-13 JP JP2000213531A patent/JP3909738B2/ja not_active Expired - Lifetime
-
2001
- 2001-07-12 KR KR1020027003248A patent/KR20020064283A/ko not_active Ceased
- 2001-07-12 CN CNB018017886A patent/CN1190665C/zh not_active Expired - Lifetime
- 2001-07-12 EP EP01949965A patent/EP1300678B1/en not_active Expired - Lifetime
- 2001-07-12 US US10/019,417 patent/US6894511B2/en not_active Expired - Lifetime
- 2001-07-12 DE DE60124716T patent/DE60124716T2/de not_active Expired - Lifetime
- 2001-07-12 WO PCT/JP2001/006067 patent/WO2002006809A1/ja not_active Ceased
- 2001-07-12 CA CA002377813A patent/CA2377813C/en not_active Expired - Lifetime
- 2001-07-13 TW TW090117202A patent/TW541433B/zh not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010041794A1 (en) * | 2008-10-08 | 2010-04-15 | Korea Institute Of Science And Technology | A flexible, multi-channel microelectrode for recording laboratory animal eeg and method for recording laboratory animal eeg using the same |
| US8798707B2 (en) | 2008-10-08 | 2014-08-05 | Korea Institute Of Science And Technology | Flexible, multi-channel microelectrode for recording laboratory animal EEG and method for recording laboratory animal EEG using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60124716T2 (de) | 2007-03-29 |
| TW541433B (en) | 2003-07-11 |
| CA2377813C (en) | 2004-11-30 |
| CN1383487A (zh) | 2002-12-04 |
| DE60124716D1 (de) | 2007-01-04 |
| US20020113607A1 (en) | 2002-08-22 |
| WO2002006809A1 (en) | 2002-01-24 |
| JP3909738B2 (ja) | 2007-04-25 |
| CN1190665C (zh) | 2005-02-23 |
| US6894511B2 (en) | 2005-05-17 |
| EP1300678B1 (en) | 2006-11-22 |
| JP2002031617A (ja) | 2002-01-31 |
| CA2377813A1 (en) | 2002-01-24 |
| EP1300678A1 (en) | 2003-04-09 |
| EP1300678A4 (en) | 2005-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| PA0105 | International application |
Patent event date: 20020312 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PA0201 | Request for examination | ||
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20040224 Patent event code: PE09021S01D |
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| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20040924 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20040224 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |